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  • 1
    Electronic Resource
    Electronic Resource
    Use of a valved, solid phosphorus source for the growth of Ga0.5In0.5P and Al0.5In0.5P by molecular beam epitaxy (1991)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 59 (1991), S. 342-344 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We report on a new method for the generation of phosphorus beams in molecular beam epitaxy: the use of a valved, solid cracker source. The valved solid source avoids previous difficulties associated with the use of solid phosphorus, and provides an attractive alternative to the use of phosphine. The use of red phosphorus does not interfere with the subsequent growth of high quality arsenides in the same growth chamber. The performance of this valved phosphorus source is illustrated by the growth of two ternary phosphides, Ga0.5In0.5P and Al0.5In0.5P. The quality of the phosphides reported here is comparable to the best results reported by other growth techniques. The effects of composition, growth temperature, and P2 flux on the films' characteristics are reported. Indium desorption during growth is found to be substantially greater in AlInP than in GaInP.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.105590
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  • 2
    Electronic Resource
    Electronic Resource
    The recombinant major allergen of Parietaria judaica and its hypoallergenic variant: in vivo evaluation in a murine model of allergic sensitization (2004)
    Oxford, UK : Blackwell Science Ltd
    Clinical & experimental allergy 34 (2004), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background  Par j 1 represents the major allergenic component of Parietaria judaica pollen. Its three-dimensional structure is stabilized by four disulphide bridges. A family of three-dimensional mutants of the recombinant Par j 1 (rPar j 1) allergen, showing reduced allergenicity and retained T cell recognition has been recently developed by site-directed mutagenesis.Objective  To develop and characterize a murine model of IgE sensitization to rPar j 1. To evaluate similarities between the murine model and the human IgE response. To investigate in this model the recognition of a hypoallergenic mutant of Par j 1, and to study the immune responses elicited in mice by the mutant itself.Methods  BALB/c mice were sensitized by two intraperitoneal immunizations with rPar j 1 in alum on days 0 and 21. Allergen-specific serum IgE and IgG responses were studied by direct ELISA and immunoblotting, ELISA inhibition and competitive ELISA. Cell proliferation was evaluated in splenocyte cultures.Results  Sensitization with rPar j 1 induced high levels of IgE and IgG1 vs. low levels of IgG2a. Mouse antibodies specific to rPar j 1 were able to compete with human IgE for recognition of rPar j 1. IgE from mice immunized with rPar j 1 showed a significantly reduced binding activity towards the hypoallergenic variant rPjC, which lacks three disulphide bridges. On the contrary, rPjC was recognized by IgG1 and IgG2a antibodies as well as rPar j 1. The proliferative response to rPjC by splenocytes from mice immunized with rPar j 1 was comparable to that stimulated by rPar j 1. Immunization with rPjC induced low levels of IgE antibodies to the rPjC itself, while IgG and proliferative responses were similar to those induced by rPar j 1.Conclusion  Conformational variants of allergens, displaying reduced allergenicity accompanied by retained IgG and T cell recognition, offer a safe, specific and flexible approach to immunotherapy of type I allergy. Our mouse model of IgE sensitization to a recombinant allergen, mimicking the human response to its native counterpart, could provide valuable information for pre-clinical testing of such hypoallergenic molecules.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.2004.01894.x
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  • 3
    Electronic Resource
    Electronic Resource
    Gastric retention of sucralfate gel and suspension in upper gastrointestinal diseases (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Alimentary pharmacology & therapeutics 7 (1993), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: This study was designed to compare by scintigraphy the gastric retention of a new dosage form of sucralfate as gel (Gastrogel) with that of sulcralfate suspension in 25 patients with upper gastrointestinal symptoms referred for routine endoscopy. After endoscopy 4 subgroups were defined: macroscopically normal mucosa (n= 7), antral gastritis and/or erosions (n= 6), gastric ulcer (n= 6) and duodenal ulcer (n= 6). Each patient received either sucralfate gel or sucralfate suspension in equivalent doses (5 ml containing 1 g sucralfate). Both formulations were labelled with 111 MBq 99m Tc-DTPA before administration. The mean value of t½ in the total group was significantly longer when patients were taking sucralfate gel (61.6 min) compared to sucralfate suspension (33.8 min) (P 〈 0.001). The mean values of t½ were significantly longer for sucralfate gel compared to sucralfate suspension also among the subgroups (macroscopically normal P 〈 0.02, antral gastritis P 〈 0.05, gastric ulcer P 〈 0.02 and duodenal ulcer P 〈 0.05). After 2 and 3 hours, the percentage residual activity in the gastric area was significantly higher following administration of sucralfate gel compared to sucralfate suspension. This study has shown that, compared to sucralfate suspension, sucralfate gel persists longer in the stomach of patients with gastritis and peptic ulcer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2036.1993.tb00129.x
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  • 4
    Electronic Resource
    Electronic Resource
    Expression of human sperm protein 17 in melanophages of cutaneous melanocytic lesions (2004)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 150 (2004), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0007-0963.2004.05887.x
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  • 5
    Electronic Resource
    Electronic Resource
    The IgE-binding epitopes of rPar j 2, a major allergen of Parietaria judaica pollen, are heterogeneously recognized among allergic subjects (2000)
    Copenhagen : Munksgaard International Publishers
    Allergy 55 (2000), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Pollen allergens are multivalent proteins that cross-link IgE antibodies on mast or basophil cells, inducing secretion of biologic mediators, and resulting in various allergic symptoms. The IgE-binding regions of the Parietaria judaica (Pj) pollen major allergen rPar j 2 were investigated. Twenty-nine single sera from Pj-allergic subjects were tested by Western blot against five recombinant peptides. At least four putative IgE-binding epitopes were identified. The analysis of their diffusion suggested a heterogeneous IgE-binding response. In fact, 75% of the sera reacted with peptide 1–54, 48% with peptide 48–101, 24% with peptide 1–30, 7% with peptide 29–54, and none with peptide 48–76. These five peptides were analyzed with the histamine-release assay. Only peptide 48–101 was capable of inducing degranulation and release of histamine. These results suggest that the recombinant rPar j 2 allergen contains IgE epitopes that are heterogeneously recognized by sensitive patients, and that therefore the therapeutic approach based on the use of haptenic peptides needs a careful evaluation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1398-9995.2000.00265.x
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  • 6
    Electronic Resource
    Electronic Resource
    1,2-Dichloropropane (DCP) toxicity is correlated with DCP-induced glutathione (GSH) depletion and is modulated by factors affecting intracellular GSH (1990)
    Springer
    Archives of toxicology 64 (1990), S. 459-465 
    Details
    ISSN: 1432-0738
    Keywords: Toxicity-1,2-Dichloropropane-Glutathione-N-acetylcysteine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Acute 1,2-dichloropropane (DCP) poisoning in humans is relatively frequent in Italy, where DCP is widely diffused as a constituent of commercial solvents and dry cleaners. In this study we have investigated the effects of DCP on intracellular glutathione (GSH) content in main target tissues of male Wistar rats, i.e. liver, kidney and blood, in order to establish if a correlation between DCP-induced GSH depletion and tissue damage exists. Administration of DCP (2 ml/kg body weight orally) caused a dramatic loss of tissue GSH occurring 24 h after DCP intoxication, followed by a slow restoration approaching physiological levels after 96 h. GSH depletion was associated with a marked increase in serum GOT, GPT, 5′-nucleotidase, gamma-glutamyl transpeptidase, alkaline phosphatase, urea and creatinine, and a significant degree of hemolysis. When animals were pretreated with a GSH depleting agent, buthionine-sulfoximine (BSO) (0.5 g/kg body weight) i. p. 4 h before DCP intoxation, an increase of overall mortality was found, significantly different from the group of animals treated with DCP alone. On the contrary, the administration of a GSH precursor, N-acetylcysteine (NAC) i. p. (250 mg/kg body weight) 2 and 16 h after DCCP intoxication prevented the dramatic loss of cellular GSH and reduced the extent of injury in target tissues, as demonstrated by laboratory indices. Furthermore, statistical analysis of the data revealed a correlation between: (1) depletion of liver GSH and increase in serum GOT, GPT, 5′-nucleotidase, (2) depletion of kidney GSH and increase in serum urea and creatinine and (3) depletion of blood GSH and the occurence of hemolysis. Our findings demonstrate that GSH plays a critical role in modulating the toxicity of DCP. They also highlight the protective role of NAC and suggest that this glutathione precursor could rationally be employed in DCP poisoning in humans.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01977627
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  • 7
    Electronic Resource
    Electronic Resource
    Dependence of thickness on the withdrawal speed for SiO2 and TiO2 coatings obtained by the dipping method (1992)
    Springer
    Journal of materials science 27 (1992), S. 5052-5056 
    Details
    ISSN: 1573-4803
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract SiO2 and TiO2 sol-gel thin films were prepared from solutions of different concentration. To fit the experimental coating thickness values, the modification of two theoretical equations, available from the literature, was used. The best-fit results were given by the approach which relates the thickness to the square root of the velocity. It was shown that, provided the same heat treatment is used for the films, the thickness of coatings obtained from solutions of different concentration and at any withdrawal speed may be predicted from just one thickness value obtained at one withdrawal speed, if the solutions' viscosity and density, are known.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01105273
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  • 8
    Electronic Resource
    Electronic Resource
    Atmosphere effects in the processing of silicon carbide and silicon oxycarbide thin films and coatings (1994)
    Springer
    Journal of sol gel science and technology 2 (1994), S. 601-604 
    Details
    ISSN: 1573-4846
    Keywords: silicon carbide ; silicon oxycarbide ; thin film
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Silicon carbide and silicon oxycarbide films were prepared from solutions of polycarbosilane and methyldimethoxysilane + tetraethoxysilane, respectively, and deposited on different substrates (Si wafers, stainless steel plates, sapphire and SiC fibers). The coatings were heated at different temperatures and in different atmospheres, such as regular grade argon, ultra high purity and argon vacuum. The films were characterized using different techniques (FT-IR, XRD, SIMS, Ellipsometry). The influence of the processing parameters (heat treatment temperature and atmosphere) on the final microstructure of the coatings is discussed in this article.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00486317
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  • 9
    Electronic Resource
    Electronic Resource
    New materials based on the reaction of cyclo- and poly-(organo phosphazenes) with SiO2, TiO2 and ZrO2 precursors (1994)
    Springer
    Journal of sol gel science and technology 2 (1994), S. 109-114 
    Details
    ISSN: 1573-4846
    Keywords: hybrid material ; organic-inorganic system ; phosphazene ; polymer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract A new class of organic-inorganic materials can be prepared, based on inorganic networks and cycloor poly-(organophosphazenes). Poly(organophosphazenes) are polymers characterized by many interesting technological properties. This report is based on a investigation on the reactivity of SiO2, TiO2 and ZrO2 precursors with different phosphazene compounds functionalized with hydroxyl groups, to prepare materials with a hybrid structure. The synthesis of these systems was studied in different experimental conditions. Evidences on the structures and properties of these materials will be presented on the basis of FTIR, SEM and thermal analysis characterization results.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00486222
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  • 10
    Electronic Resource
    Electronic Resource
    Cushing's syndrome due to a black adenoma of the adrenal gland: Lack of tumour visualization by radiocholesterol scintigraphy (1994)
    Springer
    European journal of nuclear medicine 21 (1994), S. 1367-1368 
    Details
    ISSN: 1619-7089
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02426703
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