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  • 1990-1994  (8)
  • 1985-1989  (5)
  • 1980-1984  (3)
  • 1965-1969  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Effect of dehydroepiandrosterone sulfate on the mineral accretion of chick embryo frontal bones cultivatedin vitro (1969)
    Springer
    Calcified tissue international 4 (1969), S. 39-47 
    Details
    ISSN: 1432-0827
    Keywords: Dehydroepiandrosterone ; Calcification ; Embryo ; Tissue Culture ; Bone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Description / Table of Contents: Résumé Les modes d'utilisation de glucose, le contenu de calcium et d'hydroxyproline et la densité cellulaire du perioste de les os frontaux d'embryons de poulet de 12 et 13 jours de developpement, cultivés sur coagulum de plasma, se presentant différenment à chaque âge. Cultivés avec sulfate de déhydroèpiandrostérone en concentration 1 mM, les frontaux de 12 jours montrent un synthese augmentée du matrice osseuse, celle de 13 jours se calcifient à une vélocité significativement plus grande que celle des os contôles. Le degré de calcification au quatrième jour de culture measuré par la relation calcium/hydroxyproline, suit un fonction lineáire avec le logarithme des doses de sulfate de dehydroepiandrostérone employées (0.5, 1,0 et 2,0 mM). Les renseignements obtenus indiquent que les frontaux de 13 jours, cultivés “in vitro” constituent modeles experimentaux appropriés pour étudier l'effet des androgénes sur le tissue osseux.
    Abstract: Zusammenfassung Stirnbeine von Hühnerembryonen an ihrem 12. und 13. Entwicklungstag entnommen und in vitro kultiviert zeigen verschiedene Arten der Glucoseverwertung der Periostzellendichte, des Calcium- und Hydroxyprolingehaltes. Wird Dehydroepiandrosteronsulfat dem Medium in einer 1 mM-Konzentration zugegeben, so beteiligen sich die 12tägigen Stirnbeine vorwiegend an der Knochengewebesynthese, während die 13tägigen signifikant stärker verkalken als die Kontrollen. Gemessen an der Calcium/hydroxyprolin Ratio bildet die Verkalkung der 13tägigen Stirnbeine eine lineare Funktion mit den Logarithmen der verwendeten Dosen von Dehydroepiandrosteronsulfat (0,5, 1,0 und 2,0 mM). Das in vitro kultivierte 13tägige Stirnbein schein ein geeignetes Experimentiermodell zur Studie der Dehydroepiandrosteronsulfatwirkung auf das Knochengewebe zu sein, weil es das grundlegende Phänomen (erhöhte Verkalkung) wiedergibt, welches man auch bei mit Androgenen behandelten Menschen und Tieren beobachtet.
    Notes: Abstract Chick embryo frontal bones at 12 and 13 days of development cultivatedin vitro exhibit different patterns of glucose utilization, periosteal cellular density and calcium and hydroxyproline content. When dehydroepiandrosterone sulfate is added to the medium at a concentration 1 mM, 12-day frontals engage primarily in osteoid tissue synthesis while 13-day frontals calcify at a significantly greater rate than controls. Measured with the ratio calcium/hydroxyproline, the calcification of 13-day frontals follows a linear function with the logarithm of the doses of dehydroepiandrosterone sulfate employed (0.5, 1.0 and 2.0 mM). The 13-day frontal bone cultivatedin vitro seems to be an adequate experimental model for the study of the effects of dehydroepiandrosterone sulfate on bone tissue because it reproduces the basic phenomenon (increased calcification) observed in man and animals treated with androgens.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02279104
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  • 2
    Electronic Resource
    Electronic Resource
    Controlled clinical trial of cadralazine as a second-step drug in the treatment of hypertension (1985)
    Springer
    European journal of clinical pharmacology 28 (1985), S. 135-138 
    Details
    ISSN: 1432-1041
    Keywords: hypertension ; cadralazine ; vasodilators ; chlorthalidone ; atenolol ; side-effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The antihypertensive efficacy of a new long-lasting vasodilator, cadralazine, and the diuretic chlorthalidone have been compared in hypertensive patients receiving concurrent treatment with atenolol. After a 4-week run-in period with atenolol alone 100 mg/day, two groups of 10 patients whose diastolic blood pressure exceeded 100 mm Hg were given for a period of 65 days either cadralazine 15 mg/day or chlorthalidone 25 mg/day, according to a randomized, double-blind, between-patients design. Compared to atenolol alone, both cadralazine and chlorthalidone induced a statistically and clinically significant decrease in blood pressure. The antihypertensive effect did not differ significantly between groups. Good compensation of the atenolol-induced decrease in heart rate was obtained with cadralazine, whereas during atenolol + chlorthalidone treatment at times the standing heart rate was significantly lower than during treatment with atenolol + cadralazine. Side-effects, many of which were already present during atenolol treatment, occurred with a similar frequency in both groups. It is concluded that atenolol + cadralazine and atenolol + chlorthalidone are equally well tolerated, acceptable and effective in the treatment of hypertension, but that further studies are warranted to explore the potential haemodynamic advantages of the cadralazine + atenolol combination.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00609680
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  • 3
    Electronic Resource
    Electronic Resource
    A mountain pass method for the numerical solution of semilinear wave equations (1993)
    Springer
    Numerische Mathematik 64 (1993), S. 487-509 
    Details
    ISSN: 0945-3245
    Keywords: 65M60
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Summary It is well-known that periodic solutions of semilinear wave equations can be obtained as critical points of related functionals. In the situation that we studied, there is usually an obvious solution obtained as a solution of linear problem. We formulate a dual variational problem in such a way that the obvious solution is a local minimum. We then find additional non-obvious solutions via a numerical mountain pass algorithm, based on the theorems of Ambrosetti, Rabinowitz and Ekeland. Numerical results are presented.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01388701
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  • 4
    Electronic Resource
    Electronic Resource
    Physiological investigations into the resistance of a wild mustard (Sinapis arvensis L.) biotype to auxinic herbicides (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Weed research 33 (1993), S. 0 
    Details
    ISSN: 1365-3180
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Possible mechanism(s) of resistance to auxinic herbicides in wild mustard (Sinapis arvensis L.) were investigated by characterizing responses of susceptible and resistant biotypes to 2,4-D, di-camba or picloram. No differences between bio-types were observed in absorption, translocation, or metabolism of foliar-applied radiolabelled herbicides. In contrast, the levels of ethylene production varied between biotypes. The susceptible biotype produced twofold and sixfold more ethylene than the resistant biotype within 4 h and 44 h of herbicide application, respectively. These results suggest that the mechanism of resistance in wild mustard is not due to differences in absorption, translocation, or metabolism. Ethylene production studies imply that resistance to auxinic herbicides may be attributed to altered target site(s) of action. Bases physiologiques de la résistance aux herbicides auxiniques d'un biotype de moutarde des champs (Sinapis arvensis L.)Les mécanismes possibles de la résistance aux herbicides auxiniques chez la moutarde des champs (Sinapis arvensis L.) ont été recherchés en caractérisant les réponses de biotypes résis-tants et sensibles au 2,4-D, au dicamba et au pi-clorame. Aprés application des herbicides radioactifs sur le feuillage, aucune différence d'absorption, de migration ou de métabolisme n'a été observée. Par contre, la production d'éthylene différait entre les biotypes. Le biotype sensible produisait 2 et 6 fois plus d'éthylène que le biotype sensible, respectivement 4 et 44 heures après l'application d'herbicide. Ces résultats sug-gèrent que la résistance aux herbicides auxiniques chez la moutarde des champs n'est pas due à des différences d'absorption, de migration ou de métabolisme mais pourrait provenir d'une altération du site d'action.Physiologische Untersuchung der Resistenz eines Acker-Senf-(Sinapis arvensis-) Biotyps gegenüber WuchsstoffherbizidenDer mögliche Mechanismus der Resistenz gegenüber Wuchsstoffherbiziden beim Acker-Senf (Sinapis arvensis L.) wurde unhand der Reaktion von empfindlichen und resistenten Biotypen gegenüber 2,4-D, Dicamba oder Picloram untersucht. Hinsichtlich Absorption, Translokation oder Metabolismus der auf die Blätter applizierten, radioaktiv markierten Her-bizide wurden keine Unterschiede beobachtet. Die Ethylenbildung variierte jedoch zwischen den Biotypen. Der empfindliche produzierte in-nerhalb 4 oder 44 Stunden nach der Herbizid-applikation 2-bzw. 6mal mehr Ethylen als der resistente. Aus den Ergebnissen läßt sich schließen, daß beim Acker-Senf der Resisten-zmechanismus nicht in der Absorption, der Translokation oder dem Metabolismus liegt, sondern die Ethylenbildung daran beteiligt ist, wo die Wirkorte fur die Wuchsstoffherbizide liegen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3180.1993.tb01959.x
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  • 5
    Electronic Resource
    Electronic Resource
    Postnatal Development of Ley dig Cells in the Testis of the Domestic Fowl (1987)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 513 (1987), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1987.tb25034.x
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  • 6
    Electronic Resource
    Electronic Resource
    Prevalence of hepatitis C virus infection in the household contacts of patients with HCV-related chronic liver disease (1994)
    Springer
    Infection 22 (1994), S. 183-186 
    Details
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Bedeutung der Familie als Faktor für die Ausbreitung der HCV-Infektion wird immer noch kontrovers diskutiert. In der vorliegenden Studie wurde versucht, die Prävalenz anti-HCV-positiver Fälle unter den häuslichen Kontaktpersonen von Patienten mit HCV-assoziierter chronischer Hepatitis zu bestimmen. Nahezu alle Kontaktpersonen von 113 Personen mit anti-HCV-positiver Hepatitis (100/113 Ehegatten, 260/290 Kinder) wurden untersucht. Für die Bestimmung von anti-HCV wurde ELISA-II mit Bestätigung durch RIBA II eingesetzt. 27% der Ehegatten und 1,9% der Kinder erwiesen sich als anti-HCV-positiv. Bei den Gatten korrelierte die Prävalenz der anti-HCV-Positivität mit der Dauer der Ehe. Bei 17/32 (53,1%) der anti-HCV-positiven Personen wurde eine chronische Hepatitis aufgedeckt. Diese Studie gibt Hinweise auf eine vorwiegend horizontale Übertragung der HCV-Infektion zwischen Ehegatten und eine positive Korrelation zwischen Übertragung und Dauer der Ehe.
    Notes: Summary It is still controversial whether the familial environment plays a role in the diffusion of HCV infection. The aim of this study was to evaluate the prevalence of anti-HCV positivity in the household contacts of patients with HCV-related chronic hepatitis. Nearly all the household contacts of 113 subjects with anti-HCV+ chronic hepatitis (100/113 spouses and 260/290 children) were investigated. Anti-HCV was determined by means of ELISA II and was confirmed by RIBA II. Anti-HCV positivity was found in 27% of the spouses and in 1.9% of the children. Prevalence of anti-HCV positivity in spouses correlated positively with the duration of the marital status. Seventeen/32 (53.1%) of anti-HCV-positive subjects were found to have chronic hepatitis. This study indicates that intrafamilial diffusion of HCV infection is mostly accounted for by horizontal, in particular spouse to spouse, transmission and that spouse to spouse transmission of HCV infection correlates positively with the duration of marital status.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01716699
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  • 7
    Electronic Resource
    Electronic Resource
    Characterization of a partial deletion of the factor VIII gene in a haemophiliac with inhibitor (1988)
    Springer
    Human genetics 〈Berlin〉 79 (1988), S. 86-88 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Genomic DNA from 49 Italian patients affected with severe haemophilia A was analysed by Southern blotting technique using a cDNA probe corresponding to exons 14–26 of coagulation factor VIII. No TaqI site mutation was observed in this sample. A partial deletion, eliminating exons 15–18 and spanning about 13 kb, was identified and characterized in one patient with anti-factor VIII antibodies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00291718
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  • 8
    Electronic Resource
    Electronic Resource
    Isolation procedure for bovine retinal rod outer segments (1980)
    Springer
    Cellular and molecular life sciences 36 (1980), S. 894-895 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary An isolation procedure to obtain rod outer segments from cattle retinas is reported. Centrifugation of homogenates in discontinuous and continuous sucrose density gradients yields purified photoreceptor cell outer segments. Assay of the final preparation for rhodopsin content gives a ratio of 2.4 for DO280 nm/DO498 nm.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01953777
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  • 9
    Electronic Resource
    Electronic Resource
    Polymorphism in the location of the 18S and 28S rRNA genes on the chromosomes of the diploid-tetraploid treefrogs Hyla chrysoscelis and H. versicolor (1989)
    Springer
    Chromosoma 97 (1989), S. 481-487 
    Details
    ISSN: 1432-0886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The chromosomes of the diploid Hyla chrysoscelis and its tetraploid sibling species H. versicolor were studied with AgNO3 staining and in situ hybridization to determine the chromosome location of the 18S and 28S ribosomal RNA (rRNA) genes. A total of 236 Hyla chrysoscelis from 34 localities in 15 U.S. states and 100 H. versicolor from 15 localities in 12 states were examined. The rRNA gene sites were extremely variable in H. chrysoscelis, and also variable, but to a lesser extent, in H. versicolor. The most common rRNA gene site in both H. chrysoscelis and H. versicolor was on the short arm of chromosome 6. All of the rRNA gene locations seen in H. versicolor were also seen in H. chrysoscelis, supporting the hypothesis that the tetraploid H. versicolor arose from H. chrysoscelis. Although polymorphic rRNA gene sites in H. versicolor may reflect the positions of the rRNA genes in H. chrysoscelis ancestors, the origin of the extreme variability of such sites in H. chrysoscelis seems more obscure. Possible explanations include inversions, translocations, mobile genetic elements or a combination of some or all of these.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00295033
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  • 10
    Electronic Resource
    Electronic Resource
    The effect of dehydroepiandrosterone sulfate and testosterone on the development of chick embryo frontal bones in vitro (1968)
    Springer
    Calcified tissue international 2 (1968), S. 133-144 
    Details
    ISSN: 1432-0827
    Keywords: Dehydroepiandrosterone ; Testosterone ; Embryo ; Tissue culture ; Frontal bone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Description / Table of Contents: Résumé Les os frontaux d'embryons de poulet, de 12 jours de développement, cultivés sur coagulum de plasma avec sulfate de déhydroépiandrostérone (DS) en concentration 1 mM, montrent hyperplasie du périoste et synthèse augmentée du matrice osseuse. Ces phénomenes ne son pas vus quand on emploie les os frontaux de 11 jours de développement. La testostérone produit les mêmes effets que le DS. Le deux steroïdes semblent agir directement sur l'os selon on peut le déduire des conditions expérimentales. L'activité de la phosphatase alcaline des frontaux d'embryons de poulet de 12 jours de développement est augmentée de manière significative quand les rudiments son cultivés dans un milieu qui contient DS ou testostérone. Dans ces deux cas: a) on peut révéler l'activation de l'enzyme par des expériences de cinétique enzymatique et b) les vélocités maximes apparantes ont une grande correlation avec le logarithme des doses employées. Quand les deux steroïdes son essayés en conditions semblables, les deux produisent la même augmentation de l'activité phosphatasique.
    Abstract: Zusammenfassung Wenn Stirnknochen von 12 Tage alten Hühnerembryonen in vitro auf koaguliertem Plasma mit Zusatz von 1 mM Dehydroepiandrosteronsulfat gezüchtet werden, so zeigen sie eine Hyperplasie des Periostes und eine erhöhte Synthese des Osteoidgewebes. Diese Erscheinung trifft nicht zu, ween 11 tägige Stirnknochen in gleicher Weise gezüchtet werden. Mit Testosteron werden gleiche Effekte wie mit Dehydroepiandrosteronsulfat erzielt. Aus den gewählten Versuchsverhältnissen kann abgeleitet werden, daß beide Steroide direkt auf den Knochen zu wirken scheinen. Die Aktivität der alkalischen Phosphatase im Stirnknochen des 12 Tage alten Hühnerembryos ist signifikant erhöht, wenn die Knochenansätze in einem Dehydroepiandrosteron oder Testosteron enthaltenden Medium gezüchtet werden. In beiden Fällen ergeben enzymkinetische Untersuchungen einerseits eine Aktivierung des Enzyms, andererseits eine gute Korrelation der erhaltenen scheinbaren Maximalgeschwindigkeiten mit dem Logarithmus der verwendeten Dosen. Bei gleichzeitiger Prüfung bewirkten beide Steroide gleichzeitig eine ähnliche Aktivitätszunahme der alkalischen Phosphatase.
    Notes: Abstract Chick embryo frontal bones at 12 days of development, cultivated in vitro on plasma clots with dehydroepiandrosterone sulfate in a concentration 1mM, exhibit periosteal hyperplasia and increased synthesis of osteoid tissue. These phenomena are not observed when 11-day frontals are cultivated in similar conditions. Testosterone produces the same effects as dehydroepiandrosterone sulfate. Both steroids seem to act directly on bone as can be inferred from the experimental conditions employed. The alkaline phosphatase activity of chick embryo frontal bones at 12 days of development is significantly increased when the rudiments are cultivated in a medium containing dehydro-epiandrosterone or testosterone. In both cases a) enzyme kinetics experiments revealed that there is activation of the enzyme and b) the apparent maximum velocities obtained are hihgly correlated with the logarithm of the doses employed. When assayed simultaneously, both steroids were found equally active in promoting the increase in alkaliue phosphatase activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02279202
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