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  • 1
    Electronic Resource
    Electronic Resource
    Immunolocalization of cathepsins B, H and L in skeletal muscle of X-linked muscular dystrophy (mdx) mouse (1988)
    Springer
    Acta neuropathologica 75 (1988), S. 217-225 
    Details
    ISSN: 1432-0533
    Keywords: mdx mouse ; Cathepsin L ; Macrophages ; Muscle structural proteins ; Proteolysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The amounts of non-collagen proteins (muscle structural proteins) and the activity of creatine kinase were significantly decreased in muscles of 28-day-old mdx mice. The activities of lysosomal thiol proteases such as cathepsins B and L were increased in muscles of mdx mice at as early as 10 days of age. Endogenous thiol proteinase inhibitor and various lysosomal hydrolases also showed increased activities. The localization of cathepsins B, H and L, and endogenous thiol proteinase inhibitor was investigated using the respective specific antibodies. While only invading macrophages were stained strongly with anticathepsin B and H, and anti-thiol proteinase inhibitor antibodies, cathepsin L was localized in muscle cells as well as in invading macrophages. Cathepsin L in muscle cells itself may initially degrade muscle structural proteins, before lysosomal thiol proteases, mainly derived from macrophages, degrade them in skeletal muscles of mdx mice.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00690529
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  • 2
    Electronic Resource
    Electronic Resource
    Estimate of the ultimate performance of the single-electron transistor (1994)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 75 (1994), S. 3654-3661 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The scaling limit of current semiconductor devices is thought to be about 100 nm. To reduce the size of devices beyond this point will probably require a new device technology. The metal single-electron transistor, using the Coulomb blockade effect, has been proposed as a replacement for semiconductor devices. Recently devices of this kind with potentially useful properties have been fabricated. The scaling of such devices down to atomic dimensions is investigated to see if they can compete with semiconductor logic or analog devices. It concentrates on the operation of a single device and not on the effects of integration. Until now such models for the single-electron transistor have assumed that the capacitance and conductance of the various junctions can be chosen independently, but it is demonstrated that the physical geometry causes restrictions on these choices. A second restriction is that as the device is made smaller the capacitance drops. This means that the temperature of operation rises, but so do the voltages required across the device. A point is reached where these voltages exceed the breakdown voltage of the junctions. For this reason the devices cannot be scaled indefinitely. The model predicts that if the devices are to perform logic functions or analog amplification their maximum speed will be limited to between 1 and 10 ps, which is not a great improvement on semiconductors, especially since for ultimate speed such devices will need to be 100 times smaller. The operation of such high-speed devices will not be possible at room temperature. Operation at 77 K will be possible but very difficult, and with current lithography limits of 10 nm, operation of useful logic even at 4.2 K will be marginal. The model does not rule out the use of the single-electron transistor for other purposes, such as memory and sensitive electrometers, and a process is described for the fabrication of 50 nm devices using a minimum of processing.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.356080
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  • 3
    Electronic Resource
    Electronic Resource
    Effects of an electric field on exciton recombination in three-step asymmetric coupled quantum wells (1994)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 75 (1994), S. 2105-2109 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The radiative transitions of (100)- and (311)A-oriented three-step asymmetric coupled quantum wells in an electric field are studied by photoluminescence. Four distinct transitions are observed in the spectra which exhibit remarkably complex energy shifts with the applied field. It is shown that these transitions originate from the two pairs of spatially direct and indirect heavy-hole excitons in the three-step quantum well and that their electric-field dependence is dominated by the conversion of the direct into the indirect excitons and vice versa. Furthermore, we discuss the effects of the nonconventional crystal orientation and show that substantial modifications of the basic electro-optical properties can be achieved from internal piezoelectric fields incorporated within the structure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.356315
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  • 4
    Electronic Resource
    Electronic Resource
    Depth distribution of secondary defects in 2-MeV boron-implanted silicon (1986)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 59 (1986), S. 3417-3420 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Annealing behavior of secondary defects in 2-MeV boron ion-implanted (100) silicon has been investigated mainly through cross-sectional TEM observations. The maximum defect density is located at a mean depth of 3.2 μm from the surface and the location is 0.3 μm deeper than that of the projected range of boron ions. This defect position in the crystal is constant under all annealing conditions (e.g., a temperature range of between 700 and 1000 °C, annealing time of up to 6780 min at 1000 °C), although the vertical distribution width of defects changes with both annealing temperature and time.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.336808
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  • 5
    Electronic Resource
    Electronic Resource
    Time resolved luminescence study of recombination processes in electroluminescent polymers (1993)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 62 (1993), S. 2827-2829 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Picosecond luminescence studies on poly(p-phenylene vinylene) (PPV) and related compounds in the temperature range of 10–300 K are reported. We identify a fast nonradiative and considerably slower radiative recombination channel. The fastest decay is observed in PPV. In the phenyl substituted derivative poly(phenyl-p-phenylenevinylene) a significant contribution from a slow component (∼1.3 ns) is found. Dilution of the polymer in a blend leads to an increase of the contribution of the slow component. We attribute the fast decay to luminescence quenching due to energy dependent trapping of mobile excitations whereas the slow component reflects the radiative recombination.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.109223
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  • 6
    Electronic Resource
    Electronic Resource
    Structure of 4-aminolactivinic acid (1987)
    Oxford [u.a.] : International Union of Crystallography (IUCr)
    Acta crystallographica 43 (1987), S. 1786-1788 
    Details
    ISSN: 1600-5759
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0108270187090188
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  • 7
    Electronic Resource
    Electronic Resource
    Peripheral neuropathy with predominantly motor manifestations in a patient with carcinoma of the uterus (1988)
    Springer
    Journal of neurology 235 (1988), S. 368-370 
    Details
    ISSN: 1432-1459
    Keywords: Motor-dominant neuropathy ; Carcinoma of the uterus ; Paraneoplastic syndrome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An autopsy case of a 56-year-old woman who had carcinoma of the corpus uteri and peripheral neuropathy with predominantly motor manifestations is described. The neurological abnormalities included subacute weakness of the limbs and loss of deep reflexes, which improved after the surgical removal of the uterine carcinoma. Neuropathologically, peripheral nerves mainly presented features of axonal degeneration with a mild loss of myelinated fibres. Anterior horns of the spinal cord showed central chromatolysis of the motor nerve cells and many spheroids without neuronal loss. Axonopathy of peripheral nerves was considered to be the main pathological process in this paraneoplastic syndrome.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00314236
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  • 8
    Electronic Resource
    Electronic Resource
    “Quadriceps myopathy”: a clinical variant form of becker muscular dystrophy (1990)
    Springer
    Journal of neurology 237 (1990), S. 310-312 
    Details
    ISSN: 1432-1459
    Keywords: Quadriceps myopathy ; Becker muscular dystrophy ; Dystrophin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A 26-year-old male with “quadriceps myopathy” is presented. He had a family history and only the bilateral quadriceps were wasted, without symptomatic weakness. The specimen of the muscle biopsy showed typical myopathic features without inflammatory reactions. The patchy defect of muscular dystrophin was proved by immunohistochemical study. Dystrophin analysis revealed abnormal 380 kDa dystrophin. Gene deletion was proved at exon 45–48 of Xp21 without frameshift. This case was considered to be a clinical variant form of Becker muscular dystrophy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00314749
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  • 9
    Electronic Resource
    Electronic Resource
    Fetal hemoglobin variants in 80,000 Japanese neonates: high prevalence of Hb F Yamaguchi (AγT 80 Asp→Asn) (1986)
    Springer
    Human genetics 〈Berlin〉 72 (1986), S. 196-202 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary A population-based screening of newborns for the structural variants of fetal hemoglobin was carried out in Osaka Prefecture, Japan, by isoelectric focusing of globin chains using dried blood on filter paper. Of 80,000 newborns, 18 had α globin variants and 55 had γ globin variants. The incidence of γ globin variants (1/1,455) was much higher than that of α globin variants (1/4,444). Structural studies were then carried out on the abnormal γ globins in 36 samples, and revealed that 25 of them were Hb F Yamaguchi (AγT 80 Asp→Asn). The prevalence of this variant in Japanese was estimated to be as high as one per 2,100.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00291877
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  • 10
    Electronic Resource
    Electronic Resource
    Radiation myelopathy: significance of gadolinium-DTPA enhancement in the diagnosis (1991)
    Springer
    Neuroradiology 33 (1991), S. 286-289 
    Details
    ISSN: 1432-1920
    Keywords: Radiation myelopathy ; MRI ; Gadolinium ; DTPA enhancement
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We described two cases of chronic progressive radiation myelopathy (CPRM), in which magnetic resonance imaging (MRI) was of great value for the diagnosis. Gadolinium-DTPA (Gd-DTPA) enhancement delineated precise lesions responsible for Brown-Séquard syndrome caused by CPRM in both cases. This safe, sensitive procedure will be a requisite study in patients who are suspected of CPRM.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00588240
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