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  • 1990-1994  (2)
  • 1975-1979  (1)
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  • 1990-1994  (2)
  • 1975-1979  (1)
Year
  • 1
    Electronic Resource
    Electronic Resource
    Methoxyalkyl thiazoles: A novel series of potent, orally active and enantioselective inhibitors of 5-lipoxygenase (1991)
    Springer
    Inflammation research 34 (1991), S. 110-112 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Methoxyalkyl thiazoles are novel 5-lipoxygenase inhibitors which are neither redox agents nor iron chelators and are exemplified by ICI211965 [1-(3-naphth-2-ylmethoxy)phenyl)-1-(thiazol-2-yl)propyl methyl ether]. ICI211965 potently inhibits LTC4 synthesis in murine macrophages (IC50=0.0085 μM) and its selectivity with respect to cyclo-oxygenase (〉5800) is greater than any previously reported lipoxygenase inhibitor. ICI211965 also selectively inhibits LTB4 synthesis by human bloodin vitro (IC50=0.45 μM) and rat bloodex vivo (ED50=10 mg/Kg, p.o.). Methoxyalkyl thiazoles exhibit a tight structure activity relationship and resolution of a chiral member of the series demonstrates that 5-lipoxygenase inhibition resides largely in one enantiomer. Methoxyalkyl thiazoles represent the first class of agents for which 5-lipoxygenase inhibition is mediated by specific, enantioselective interaction with the enzyme.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01993252
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Fluctuations in inelastic proton scattering from58Ni in the energy range 17.1 to 20.6 MeV (1978)
    Springer
    The European physical journal 286 (1978), S. 307-311 
    Details
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Excitation functions of proton elastic and inelastic scattering on58Ni have been measured for proton energies in the range 17.1 to 20.6 MeV, at laboratory angles of 90°, 120° and 155°. All show cross section fluctuations. Excitation functions are presented for the elastic and for five inelastic groups in the energy range 18.1 to 18.59 MeV. These were analyzed by the Fourier analysis method, and the average level width found to be about 13 keV. The observation of strong fluctuations in the higher inelastic yields has implications for several microscopic analyses reported in the literature of58Ni(p, p′) data obtained at 17.7 MeV incident proton energy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01408262
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    A simple staining procedure for the characterisation of Basidiomycetes pellets by image analysis (1994)
    Springer
    Biotechnology techniques 8 (1994), S. 395-400 
    Details
    ISSN: 1573-6784
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Summary A simple staining procedure, associated with image analysis, was used to discriminate two zones (the filamentous zones and the compacted cores) in aggregates of fungal biomass according to their accessibility for an agent of the medium. The application of the method to batch fermentations of Schizophyllum commune showed a higher proportion of loosely entangled particles (clumps) and thinner filamentous outer zones obtained at a high agitation speed (500 rpm) compared to low agitation speeds (120–200 rpm).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00154310
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    Paper (German National Licenses)
    Fulltext
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