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  • 1
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 61 (1993), S. 0 
    ISSN: 1471-4159
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Abstract: The effect of pentobarbital on the induction of heat shock protein (HSP) 70 and heat shock cognate protein (HSC) 70 mRNAs after transient global ischemia in gerbil brains was investigated by in situ hybridization using cloned cDNA probes selective for each mRNA species. In sham control brains, HSP70 mRNA was scarcely present, whereas HSC70 mRNA was present in most cell populations. After a 5-min occlusion of bilateral common carotid arteries, HSP70 and HSC70 mRNAs were induced together in several cells and were especially dense in hippocampal dentate granule cells at 3 h, but the strong hybridization of the mRNAs continued only in hippocampal CA1 cells by 2 days. At 7 days after the ischemia, CA1 neuronal cell death was apparent, and the HSP70 mRNA disappeared and HSC70 mRNA content returned to the sham level, except for in the CA1 cells. Pretreatment with pentobarbital (40 mg/kg, i.p.) greatly reduced or inhibited the induction of HSP70 and HSC70 mRNAs at both early (3-h) and late (2-day) phases after ischemia. The drug also prevented CA1 cell death at 7 days along with the maintenance of expression of HSC70 mRNA at the sham control level. Hypothermic effects of pentobarbital were noted at 30 and 60 min after the reperfusion, whereas at 2 h there was no statistical significance between the control and drug-treated groups. The great reduction of HSP70 and HSC70 mRNA induction at both early and late phases after ischemia suggests that pentobarbital reduces intra- and/or postischemic stress and may protect CA1 cells from ischemic damage. These effects of the drug may be mainly due to its specific action rather than its hypothermic effects.
    Materialart: Digitale Medien
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  • 2
    Digitale Medien
    Digitale Medien
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 67 (1990), S. 5082-5082 
    ISSN: 1089-7550
    Quelle: AIP Digital Archive
    Thema: Physik
    Notizen: The new frames in physics has united the physics of materials and a new terminology of supercorresponding c- and q-number systems is introduced for the classical and quantal physics. In the q-number system, the electron field as represented by the Schrödinger or Dirac wave function is regarded as the electron itself, which interacts with the zero-point photon field and gives the mass renormalization. The new frames can analyze this subject without the divergence difficulty. The resultant decrease in the self-energy of the electron of about 1 eV is proposed to be dependent on the environmental crystal situation, and may become cooperative to generate coherence to the conduction electron-photon coupled system. Our basic c-number equation includes the vector potential of the interacting photon field, the microscopic electronic electric current, the frequency of the considered photon field, the original plasma frequency of the conduction electrons, and an equivalent frequency and the resonance frequency of the bound-state electrons. Placing reasonable values for these constants, we get a detailed k-ω diagram for the photon-electron field complex. By the action of the bound-state electrons, the original plasma frequency of about 4 eV is separated into two, with the lower value of about 1.7 eV (2.6×1015 s−1). This branch crosses the free-photon mode near the same frequency, opening a sharp narrow window for the zero-point free-photon field. The Fermi frequency of the conduction electrons is about the same with the wavelength of about 10 A(ring), which may fit one of the crystal dimensions. The zero-point photon-electron field complex at this frequency may couple to the electron field at the Fermi level through the induced zero-point ripple electron field. The Heisenberg uncertainty, ΔEΔt≥(h-dash-bar), may operate to the window for generating the longer time-space coherence. We call this mechanism CRCG (crystallo-radiative coherence generator).
    Materialart: Digitale Medien
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  • 3
    Digitale Medien
    Digitale Medien
    Oxford, U.K. and Cambridge, USA : Blackwell Science Ltd
    Histopathology 29 (1996), S. 0 
    ISSN: 1365-2559
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: We examined full thickness specimens of oesophageal squamous dysplasia from both cancer-free and cancer patients using immunohistochemical labelling for cytokeratin subtypes 10/13 and 14 and for involucrin, binding studies for various lectins, and PAS/D staining before and after diastase treatment. We studied specimens from patients with oesophageal carcinoma (52 normal epithelia, and 49 with mild, 38 with moderate, and 32 with severe dysplasia), and 32 specimens from cancer-free patients (five normal epithelia and 16 with mild and 11 with moderate dysplasia). Abnormal cytokeratin expression patterns in atypical cells, i.e. both cytokeratin 10/13 and cytokeratin 14 immunoreactivity in the same cells was detected in 41 of 99 specimens with dysplasias in cancer patients. Helix aspersaErythrina cristagalli and Robinia pseudoacacia binding was consistently negative in atypical cells in squamous dysplasia. The non-atypical layer of squamous dysplasia, which was morphologically indistinguishable from the corresponding layer of normal oesophageal squamous epithelium, showed abnormal involucrin expression in 39/101 specimens, Helix aspersa binding in 74/106, diastase sensitive PAS staining in 52/110, Erythrina cristaglli binding in 28/107, and Robinia pseudoacacia binding in 16/100. There were no significant differences in the expression of these markers in dysplasia between cancer patients and cancer-free individuals with the exception of increased Robinia pseudoacacia binding in the non-atypical layer in cancer-free patients. The results indicate that abnormal patterns of cytokeratin expression and lectin binding occur not only in atypical cells but also in non-atypical cells in oesophageal squamous dysplasia.
    Materialart: Digitale Medien
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  • 4
    ISSN: 1440-1797
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Materialart: Digitale Medien
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  • 5
    ISSN: 1574-695X
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Biologie , Medizin
    Notizen: The participation of adhesion molecules in systemic vascular injuries of the generalized Shwartzman reaction was studied. The generalized Shwartzman reaction was induced in mice by two consecutive injections of lipopolysaccharide. Intercellular adhesion molecule-1 (ICAM-1) was expressed on vascular endothelial cells, renal tubular cells and alveolar wall in generalized Shwartzman reaction-induced mice. The preparative injection of lipopolysaccharides induced ICAM-1 expression in those cells, and the provocative injection of lipopolysaccharides for the generalized Shwartzman reaction augmented it further. The simultaneous administration of anti-gamma interferon antibody with the preparative injection of lipopolysaccharides completely inhibited ICAM-1 expression on vascular endothelial cells. The injection of recombinant gamma interferon in replacement of lipopolysaccharides resulted in ICAM-1 expression. The administration of anti-ICAM-1 antibody together with the provocative injection of lipopolysaccharides significantly blocked the apoptosis of vascular endothelial cells in generalized Shwartzman reaction-induced mice. It was suggested that ICAM-1 expression on vascular endothelial cells might be involved in systemic vascular injuries of the generalized Shwartzman reaction, and that it might be regulated by gamma interferon.
    Materialart: Digitale Medien
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  • 6
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Publishing Ltd
    FEMS immunology and medical microbiology 16 (1996), S. 0 
    ISSN: 1574-695X
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Biologie , Medizin
    Notizen: Abstract The participation of apoptotic cell death in the generalized Shwartzman reaction was examined. The generalized Shwartzman reaction was induced in mice by two consecutive injections of lipopolysaccharide. Vascular endothelial cells in various organs of those mice were stained positively by the in situ specific labeling of fragmented DNA. Renal tubules were also stained focally. It was suggested that apoptotic cell death might participate in the development of vascular endothelial cell damage and acute tubular necrosis in the generalized Shwartzman reaction. Simultaneous administration of anti-γ-interferon antibody in the preparative injection of lipopolysaccharide completely blocked apoptosis of vascular endothelial cells. Priming with recombinant γ-interferon instead of lipopolysaccharide could produce apoptosis of vascular endothelial cells. It was suggested that γ-interferon might play a critical role on sensitization of endothelial cells for apoptosis.
    Materialart: Digitale Medien
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  • 7
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food science 61 (1996), S. 0 
    ISSN: 1750-3841
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Land- und Forstwirtschaft, Gartenbau, Fischereiwirtschaft, Hauswirtschaft , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: Activity of fish muscle glutathione peroxidase, which presumably protects muscle from oxidative deterioration during storage and processing, was found in both Japanese jack mackerel and skipjack tuna. Activity of the peroxidase and level of reduced glutathione (enzyme substrate) decreased during 5 days storage at 4°C. Lipid hydroperoxides were substantially formed in the fish muscles during the storage.
    Materialart: Digitale Medien
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  • 8
    Digitale Medien
    Digitale Medien
    Springer
    International orthopaedics 21 (1997), S. 62-66 
    ISSN: 1432-5195
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Résumé. Nous rapportons l’action de l’injection épidurale caudale préopératoire d’un mélange de bupivacaine et de buprénorphine appliquée sous anesthésie générale pour diminuer ls douleurs après fusion lombaire inter-somatique ou laminotomie pour sténose. Les douleurs ont été comparées chez les groupes avec ou sans bloc épidural: 24 et 23 patients respectivement ayant subi une arthrodèse lombaire et 30 et 28 patients respectivement ayant subi une laminotomie. Dans les 12 premières heures postopératoires, le groupe avec blocage épidural a nécessité moins souvent des analgésies additionnelles (suppositoire de diclofénac ou pentazocine intra-musculaire) et le score de l’échelle analogique visuelle était meilleur que dans le groupe sans injection épidurale. Dans les secondes 24 h et plus tard, les patients qui avaient une chute tensionnelle de plus de 10 mm de mercure après l’injection épidurale ont eu moins besoin d’analgésie additionnelle que ceux sans bloc épidural et cela pour les deux types d’intervention; d’autre part, le score analogique visuel a été meilleur que dans le groupe sans bloc pour l’intervention de laminotomie mais pas pour l’intervention de fusion inter-somatique. Il n’y a jamais eu de blocage moteur post-opératoire. Cette étude prouve que l’injection épidurale est une méthode simple pour diminuer les douleurs. Chez les patients qui ont eu une baisse de tension artérielle par blocage sympathique, l’effet s’est poursuivi même après que l’action analgésique avait disparu.
    Notizen: Summary. We report the effect of pre-incisional caudal epidural injection of a mixture of 20 ml 0.25% bupivacaine and 0.1 mg buprenorphine performed under general anaesthesia for relieving wound pain after posterior interbody fusion and laminotomy for spinal stenosis. Pain was compared in groups with and without blockade: 24 and 23 patients with fusion, and 30 and 28 with laminotomy respectively. In the first 12 h after each operation, the group with blockade required additional analgesics less frequently and had a lower visual analogue scale score than those without blockade. In, and after, the second 24 h patients with hypotension of 10 mm Hg, or more, after the blockade required additional analgesics less frequently than those without blockade for both operations and had a lower visual analogue score than those without blockade for laminotomy, but not for fusion. This is a simple procedure for relieving wound pain and in patients with hypotension caused by the block, the effect continued even after the analgesic action had disappeared.
    Materialart: Digitale Medien
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  • 9
    ISSN: 1432-1920
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 10
    Digitale Medien
    Digitale Medien
    Springer
    Neuroradiology 32 (1990), S. 166-167 
    ISSN: 1432-1920
    Schlagwort(e): Gemistocytic astrocytoma ; MR images ; Protein hydration layer
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary A gemistocytic astrocytoma demonstrating high intensity on both T1W and T2W MR images is reported. Astrocytoma usually shows low density in T1WI. This peculiar astrocytoma showed no hemorrhage, hemosiderin deposits, melanin or iron. Shortening of T1 relaxation time may be caused by protein hydration layer due to protein rich tumor cells.
    Materialart: Digitale Medien
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