Bibliothek

X
feed icon rss

Ihre E-Mail wurde erfolgreich gesendet. Bitte prüfen Sie Ihren Maileingang.

Leider ist ein Fehler beim E-Mail-Versand aufgetreten. Bitte versuchen Sie es erneut.

Vorgang fortführen?

Exportieren
  • 1
    Digitale Medien
    Digitale Medien
    Histological evaluation of interleukin-1β and collagen in gingival tissue from untreated adult periodontitis (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of periodontal research 29 (1994), S. 0 
    Details
    ISSN: 1600-0765
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Interleukin-1 beta (IL-1β) may be related to the pathological processes associated with periodontitis, primarily due to its ability to induce collagenase, increase neutrophil chemotaxis, and stimulate bone resorption. This study was designed to histologically quantitate IL-1β positive cells from various histologic fields in untreated gingivitis/early periodontitis (G/EP) versus moderate /severe periodontitis (M/SP) gingival tissues, and associate these with collagen loss. Two gingival biopsies from 8 patients were collected, one from a G/EP site and one from a M/SP site. Mouse monoclonal antibodies in combination with an avidin-biotin-peroxidase system were used to stain for IL-1β, while the van Gieson method was used to stain for collagen in serial sections. Collagen loss in G/EP (35%) and M/SP (52%) fields was consistent with gingivitis and periodontitis, respectively. IL-1β positive cells in combined coronal/sulcular (Co/Su) and apical/sulcular (Ap/Su) fields (nearest the bacterial insult) were significantly more numerous compared to combined coronal/middle (Co/Mi) and apical/middle (Ap/Mi) fields (p 〈 0.05). While numbers and percentages of IL-1β positive cells were generally higher in M/SP biopsies, differences were not significant. Further, there was no correlation between the number of IL-1β positive cells and percent collagen loss. However, a significant correlation between IL-1β positive cells and corresponding gingival crevicular fluid IL-1β concentrations was noted (r = 0.65, p = 0.01). Through the use of immunohisto-chemistry, this study demonstrated that the presence of IL-lβ+ cells does not appear to have a direct association with collagen loss.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1600-0765.1994.tb01091.x
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Artikel (Nationallizenzen)
    Volltext
  • 2
    Digitale Medien
    Digitale Medien
    Immunopathogenesis of chronic inflammatory periodontal disease: cellular and molecular mechanisms (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of periodontal research 28 (1993), S. 0 
    Details
    ISSN: 1600-0765
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Recent studies of the cellular mechanisms involved in chronic inflammatory periodontal disease (CIPD) have contributed significantly to our understanding of the pathogenesis of the disease process. Functional studies have demonstrated polymorphonuclear neutrophil (PMN) chemotactic defects in some 70% of subjects with localized juvenile periodontitis while chemiluminescence data have suggested that periphertal blood PMNs from young subjects with adult periodontitis (AP) may be in a metabolically active state. Further studies have shown that stimulation of PMNs with a number of periodontopathic bacteria resulted in the production of an IL-1 inhibitor suggesting a possible regulatory role for PMNs in CIPD in addition to their established protective role. Most work on the immunoregulation of CIPD has, however, concentrated on T-cells. Recent limit dilution analysis has demonstrated the presence of periodontopathic bacteria-specific T cells in peripheral blood and the involvement and homing of these cells to the local lesions of CIPD is currently the focus of many studies. In animal studies, Actinobacillus actinomycetemcomitans (Aa)-specific T-cell clones home to the gingival tissues where they may exert a protective role. Homing and retention of lymphocytes to and in specific sites is dependent upon the expression of adhesion molecules. Recent data indicate however, that while there are increasing levels of ICAM-1, LECAM-1 and PECAM-1 expression with increasing degrees of inflammation, there are no differences between gingivitis and periodontitis lesions. Cytokine profiles may be related to the role of T-cell clones homing to the gingiva in CIPD. In subjects susceptible to periodontal breakdown there may be an increase in the type 2 IL-4 producing T-cells whereas in non-susceptible subjects, type 1 IL-2/IFN-γ producing T-cells may preferentially home to the gingiva. This hypothesis is generally supported by recent data obtained from human studies but data obtained from animal studies is only partly supportive and may suggest the opposite. Nevertheless, it is now possible to construct a testable framework or model of CIPD based on these cellular and molecular mechanisms.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1600-0765.1993.tb02108.x
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Artikel (Nationallizenzen)
    Volltext
  • 3
    Digitale Medien
    Digitale Medien
    Prostaglandin E2 and interleukin-1 levels in smokeless tobacco-induced oral mucosal lesions (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of periodontal research 29 (1994), S. 0 
    Details
    ISSN: 1600-0765
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Inflammatory mediators released as a result of smokeless tobacco (ST)-induced irritation may play a role in the development of oral mucosal lesions at habitual tobacco placement sites in ST users. The present study examined levels of interleukin-1 (IL-1) and prostaglandin E2 (PGE2) in ST-induced mucosal lesions and compared these to mediator levels in clinically normal mucosa. Soft tissue biopsies were obtained from white mucosal lesions at habitual placement sites and normal alveolar mucosal tissue at non-placement sites in 18 ST users. Fifteen non-tobacco using subjects also provided normal alveolar mucosal biopsies. IL-1 and PGE2 were recovered from the specimens, and mediator levels were determined by enzyme immunoassay. Prostaglandin E2 levels (pg/mg) were lower in both regions in the ST subjects, but values did not vary significantly between the regions with 2.77±0.72 and 2.86±0.99 at placement and non-placement sites, respectively, in ST users and 7.31±3.84 in non-tobacco users. Both IL-1α and IL-lβ (pg/mg) were significantly (p 〈 0.0I) elevated in ST lesions (IL-lã=25.56±4.00; IL-1β=7.76±1.68) compared to either non-placement sites in ST users (IL-lα=14.64±2.65; IL-lβ=1.63±0.72) or non-tobacco users (IL-lα=12.84±2.60; IL-lβ=2.04±0.75). In view of IL-l's role in keratinocyte proliferation and its inflammatory effects, this cytokine may contribute to mucosal and gingival alterations observed in ST users.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1600-0765.1994.tb01245.x
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Artikel (Nationallizenzen)
    Volltext
  • 4
    Digitale Medien
    Digitale Medien
    Acute-phase protein detection and quantification in gingival crevicular fluid by direct and indirect immunodot (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of clinical periodontology 18 (1991), S. 0 
    Details
    ISSN: 1600-051X
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Abstract The development of an assay for markers of active periodontitis, obtained directly from gingival crevicular fluid (GCF) and simply quantified, would be of great importance to the dental practitioner. The purpose of this study was to evaluate direct and indirect immunodot techniques as to their potential in easily quantifying acute-phase proteins within periodontally diseased and healthy site GCF. Indirect immunodots (GCF eluates dotted onto nitrocellulose membrane) using monoclonal antibodies and a radioactive isotope label were used to identify and establish relative amounts of C-reactive protein (CRP) and alpha-2-macroglobulin (A2M) in 2 diseased and 2 healthy sites in 24 periodontitis patients. Periodontally diseased sites were found to contain significantly lower concentrations of A2M than healthy sites (p 〈 0.001), but CRP levels did not vary significantly between healthy and diseased locations. Using a direct immunodot assay (GCF absorbed directly into nitrocellulose membrane strips), A2M levels quantified with radioactive isotopes at healthy and diseased sites could be correlated with A2M levels determined by enzyme-linked antibody-colormetric probes at those same sites. Such a direct sampling and quantification system shows promise for future “in-office” diagnostic methodology.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1600-051X.1991.tb01697.x
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Artikel (Nationallizenzen)
    Volltext
  • 5
    Digitale Medien
    Digitale Medien
    Non yrast spectroscopy with the (α, n) reaction at the coulomb barrier (1984)
    Springer
    The European physical journal 315 (1984), S. 77-79 
    Details
    ISSN: 1434-601X
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Physik
    Notizen: Abstract About 50 states with spins ≦8ħ in128Xe have been populated by means of the125Te (α, n) reaction at projectile energies near the Coulomb barrier. In particular eight 2+ or (1,2+) states have been observed. The (α, n) reaction at particle energies near the Coulomb barrier seems to be a powerful tool to by-pass the strong selectivity for the yrast states in normal (HI, xn) reactions.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01436211
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Artikel (Nationallizenzen)
    Volltext
  • 6
    Digitale Medien
    Digitale Medien
    Excited states in124Xe (1984)
    Springer
    The European physical journal 318 (1984), S. 123-124 
    Details
    ISSN: 1434-601X
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Physik
    Notizen: Abstract Excited states of124Xe have been investigated via the122Te(α, 2n),114Cd(13C, 3n) and108Pd(19F, p2n) reactions using in-beam gamma-ray and electron spectroscopy methods. 36 new levels and several spin and parity assignments were established, revealing the existence of at least one positive parity superband and two negative parity bands, one of them showing backbending.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02117224
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Artikel (Nationallizenzen)
    Volltext
  • 7
    Digitale Medien
    Digitale Medien
    On the parity of the yrast 8+ level in138Ce and an anomaly in theB(E2) values (1984)
    Springer
    The European physical journal 318 (1984), S. 195-197 
    Details
    ISSN: 1434-601X
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Physik
    Notizen: Abstract On the basis of conversion electron andγ-angular distribution measurements new spin and parity assignments in138Ce have been made. They lead together with the already known lifetime of the 10+ yrast state whose parity was unclear to an extremely low transition probability of the 10+→8+ transition. A comparison with neighbouring even isotopes is made.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01413468
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Artikel (Nationallizenzen)
    Volltext
  • 8
    Digitale Medien
    Digitale Medien
    Band structures in73Se (1991)
    Springer
    The European physical journal 340 (1991), S. 141-153 
    Details
    ISSN: 1434-601X
    Schlagwort(e): 21.10.Re ; 23.30.Lv ; 27.60.+j
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Physik
    Notizen: Abstract Excited states of73Se have been investigated up to spin, 21/2 using techniques of in-beamγ-ray spectroscopy in connection with the70Ge(α, n) reaction. Mean lifetimes of 12 levels have been determined applying Doppler-shift andγ-RF-methods. Five different bands have been identified that reflect a variety of different excitation modes. The decoupled 9/2+ band is likely to correspond to an oblate deformation while the 5/2+ band is interpreted as a strongly coupled prolate band built on the Nilsson configuration [422] 5/2+. The 3/2− band is a strongly coupled band built on the [301] 3/2} configuration.Nuclear reactions:70Ge(α,n),E=14, 16, 18, 19, 20MeV; measuredE γ,I γ,σ(E γ,θ),γγ-coin, linear polarization, DSA,γ(t).75Se deduced levels,I, π, τ, δ(E2/M1), B(σλ). Enriched targets, Ge detectors.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01303825
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Artikel (Nationallizenzen)
    Volltext
  • 9
    Digitale Medien
    Digitale Medien
    Single channel conductance of monazomycin (1980)
    Springer
    European biophysics journal 6 (1980), S. 80-80 
    Details
    ISSN: 1432-1017
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Physik
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00647552
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Artikel (Nationallizenzen)
    Volltext
  • 10
    Digitale Medien
    Digitale Medien
    Infektion (1937)
    Springer
    Journal of cancer research and clinical oncology 45 (1937), S. 188-195 
    Details
    ISSN: 1432-1335
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01638952
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Artikel (Nationallizenzen)
    Volltext
Schließen ⊗
Diese Webseite nutzt Cookies und das Analyse-Tool Matomo. Weitere Informationen finden Sie hier...