Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Two Toxic Kaurene Glycosides from the Burrs of Xanthium pungens (1990)
    s.l. : American Chemical Society
    Journal of natural products 53 (1990), S. 451-455 
    Details
    ISSN: 1520-6025
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/np50068a025
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    A TEM study of the internal structures of an Fe-Ni metallic glass (1990)
    Springer
    Journal of materials science 9 (1990), S. 852-853 
    Details
    ISSN: 1573-4811
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00720181
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Palliation of esophageal cancer — operative resection versus laser and afterloading therapy (1991)
    Springer
    Surgical endoscopy and other interventional techniques 5 (1991), S. 4-8 
    Details
    ISSN: 1432-2218
    Keywords: End-stage esophageal cancer ; Dysphagia ; Stenosis-free interval ; Quality of life
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Since 1985, 71 patients with end-stage esophageal cancer have been treated either by surgical (n=26) or endoscopic laser palliation (n=45). In 16 of 45 patients treated by endoscopy, additional radiotherapy (extrenal and endoluminal irradiation) was performed. Surgery and Nd:YAG recanalization were initially effective in removing the malignant obstruction in 80% of cases. There were no significant differences in survival in either group. The stenosis-free interval was longer in patients who underwent surgery: 24 weeks; minimal stenosis-free interval: 20 weeks. Local recurrences occurred earlier in the endoscopic study group (mean survival: 36 weeks; minimal stenosis-free interval: 20 weeks). Most stenoses successfully underwent further laser treatment. Although only 35% of patients treated endoscopically underwent additional afterloading therapy, this treatment appears to prolong palliation (mean survival: 38 weeks; minimal stenosis-free interval: 36 weeks). A few patients bled after endoscopy and were treated conservatively. The most important complication in the afterloading group was esophagobronchial perforation, which caused one death in our series. Transient pulmonary problems were the most common complication (31%) in the surgical group with a hospital mortality of 19%. Overall, the improvement in the quality of life after surgery was better. However, our results show that Nd:YAG recanalization and afterloading therapy are effective therapeutic alternatives in patients unfit for surgery.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00591377
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Differential expression of drug metabolizing enzymes in primary and secondary liver neoplasm: immunohistochemical characterization of cytochrome P4503A and glutathione-S-transferase (1993)
    Springer
    Histochemistry and cell biology 99 (1993), S. 443-451 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The question whether expression of drug metabolizing enzymes in human liver is altered by liver neoplasm remains controversial; however, the ability or unability of tumour cells to metabolize certain drugs may be important for developing therapeutic strategies. We therefore investigated the abundance and localization of two classes of drug metabolizing enzymes [cytochrome P4503A (CYP3A) and pi-type glutathione-S-transferase] by means of immunohistochemistry (standard ABC technique) in patients with hepatocellular carcinoma (HCC, n=16) and with liver metastasis from adenocarcinoma (n=53) in comparison to normal controls (n=5). The distribution of CYP3A in normal liver samples showed a characteristic pattern of four to five layers of stained hepatocytes surrounding the central vein. Eleven out of 16 cases of HCC showed expression of CYP3A; staining was less intense than in normal liver and zonation was completely lost. In contrast, only 5 out of 53 samples of metastasis stained positively for CYP3A. The difference between primary and secondary neoplasm was statistically significant (chi-square, P〈0.0001). Pi-type glutathione-S-transferase (GST) stained positively in 9 out of 16 HCC and in 48 out of 53 cases of liver metastasis (chi-square, P〈0.01) indicating a higher percentage of immunostaining in liver metastasis. In summary, we observed differenes in the abundance and distribution pattern of CYP3A and GST between primary and secondary neoplasma of human liver and in comparison to normal controls. In combination with established methods these data may contribute to the establishment of reliable test systems for distinguishing primary from secondary liver tumours. The mechanisms of different expression of drug metabolizing enzymes in relation to tumour type and the possible consequences for drug action remain to be elucidated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00274096
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Two-dimensional electrophoresis of synovial tissue, synovial fluid and serum in patients with rheumatoid arthritis and related diseases (1990)
    Springer
    Rheumatology international 10 (1990), S. 177-183 
    Details
    ISSN: 1437-160X
    Keywords: Rheumatoid arthritis ; Immunoglobulins ; Protein pattern ; Two-dimensional electrophoresis ; Synovial membrane
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Using the technique of two-dimensional (2D) electrophoresis with consecutive silver staining, we investigated samples of serum, synovial fluid and synovial tissue obtained from 19 patients suffering from rheumatoid arthritis (RA) or non-RA arthritis. From these experiments we have drawn the following conclusions. 2D electrophoresis of serum, synovial fluid and synovial tissue extracts taken from patients suffering from joint diseases is a reproducible method. Repeated runs of the same sample reveal an essentially constant protein spot pattern. The time period between surgery and tissue preparation did not influence the number of protein spots when less than 15 h was involved. The protein spot number is always lower in synovial fluid than in either synovial tissue or serum in RA and non-RA patients. The mean value for the number of spots is 68 for the inflamed tissue irrespective of the cause of arthritis (RA and non-RA group taken together) and 47 for the control group. This difference is significant. We were able to definitely identify 7 spots in the tissue extract. We did not find RA-specific protein spots in either serum, synovial fluid or tissue extracts from the synovial membrane. The only significant difference between RA patients and either non-RA or control group patients concerning the protein spot pattern is the increased size of the immunoglobulin spot (mainly IgG) in RA. In addition, we discuss possible reasons for failure of the 2D electrophoresis technique to detect disease-specific protein patterns.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02274830
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Persistence of B19 parvovirus in synovial membranes of patients with rheumatoid arthritis (1992)
    Springer
    Rheumatology international 12 (1992), S. 147-151 
    Details
    ISSN: 1437-160X
    Keywords: Rheumatoid arthritis ; B19 parvovirus ; Polymerase chain reaction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Recent clinical observations support the hypothesis that persistent parvovirus B19 is a triggering factor of rheumatoid arthritis (RA) in certain genetically predisposed individuals. If this hypothesis is correct, a number of RA patients may exhibit parvovirus B19 DNA in their synovial membranes. We tested the synovial tissue and peripheral blood leukocytes of 20 patients with RA, 24 patients with other arthritides or osteoarthritis (non-RA), and 34 healthy blood donors for the presence of parvovirus B19 DNA using specific DNA amplification by polymerase chain reaction (PCR). Using this technique, parvovirus B19 DNA was demonstrated in the synovial biopsies of 75% of patients with RA but in those of only 16.7% of patients with non-RA. In autologous peripheral blood mononuclear cells the percentage of PCR-positive patients was about 15% in both RA and non-RA groups and did not differ from that in healthy controls. When the PCR data were correlated with the presence of anti-parvovirus B19 IgG antibodies in serum and synovia all patients with parvovirus B19 DNA in peripheral blood alone or in both peripheral blood and synovial membrane were seropositive. In contrast, about 40% of patients with parvovirus B19 DNA restricted to the synovial membrane were seronegative. These data indicate a highly disease-related persistence of parvovirus B19 in the rheumatoid synovium.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00274934
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    The neo-synovial membrane of patients with active rheumatoid arthritis at resynovectomy (1990)
    Springer
    Rheumatology international 10 (1990), S. 191-198 
    Details
    ISSN: 1437-160X
    Keywords: Rheumatoid arthritis ; Synovitis ; Synovial membrane ; Neo-synovial membrane ; Resynovectomy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Neo-synovial membranes, which formed after “primary” synovectomy in 21 patients with rheumatoid arthritis (RA), were studied at resynovectomy. The clinical, histomorphological, and immunohistological data were compared with data derived from “primary” synovial membranes from RA and osteoarthritis (OA) patients. The clinical data suggest a less active rheumatoid inflammatory response after synovectomy. Histomorphologicaly, the synovitis in resynovectomized neosynovial membranes of RA revealed no qualitative differences when compared with synovitis in the “primary” synovium. However, the degree of the inflammatory rection evaluated by the different parameters was found to be distinctly lower. The immunohistological data correlated with these findings.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02274832
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    Aboveground vegetation effects on the deposition and cycling of atmospheric sulfur: Chemical and stable isotope evidence (1991)
    Springer
    Water, air & soil pollution 60 (1991), S. 55-82 
    Details
    ISSN: 1573-2932
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract Up to 60% of the sulfate in upland forest throughfall and stemflow at Plastic Lake in central Ontario is non-precipitation by origin, but is derived from aboveground vegetation. The sources of this aboveground vegetation sulfate include dry deposited aerosols and SO2, and mineralized plant organic S. σ34S data indicate that atmospheric S dominates the upland forest ecosystems of southern and central Ontario, with little S isotope fractionation. Seasonal σ34S variations in precipitation sulfate may be due to mixing of bacteriogenic and anthropogenic S. σ18O and concentration data indicate that oxidation of dry-deposited SO2, and mineralization of organic S on vegetation surfaces may contribute one third or more of throughfall sulfate in summer and autumn, but less in late spring, perhaps due to foliar uptake of S during this season. Oxidized SO2, or mineralized organic S contributes one third or more of stemflow sulfate during these seasons.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00293966
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 9
    Electronic Resource
    Electronic Resource
    Zur Frage der Aminosäureisomerisierung im Mikrowellenfeld Ergebnisse eines Modellversuches mit Standardlösungen (1992)
    Springer
    European journal of nutrition 31 (1992), S. 219-224 
    Details
    ISSN: 1436-6215
    Keywords: D-Aminosäuren ; Isomerisierung ; Mikrowellen ; konventionelles Erhitzen ; D-amino acids ; isomerization ; microwaves ; conventionalheating
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Medicine
    Description / Table of Contents: Summary Aqueous standard-solutions of L-alanine, L-glutamic acid, and L-proline do not reveal any increase of D-enantiomers after 30 min heating — neither by the conventional method on a hotplate, nor in a standard microwave oven. A specific “microwave effect” and, hence, a special consumer risk is, in contrast to recent assumptions, not detectable. Effects on the amino acids which were observed in conventionally heated samples are explained by higher heat-exposure during the treatment of these samples.
    Notes: Zusammenfassung In wäßrigen Modell-Lösungen von L-Alanin, L-Glutaminsäure und L-Prolin läßt sich nach einer halben Stunde Sieden auf der Herdplatte im Vergleich mit einer zeitgleichen Hitzebehandlung im haushaltsüblichen Mikrowellenofen keine Zunahme an D-Enantiomeren nachweisen. Ein spezifischer ‚Mikrowelleneffekt‘ und somit ein spezielles Verbraucherrisiko, wie kürzlich postuliert, ist nicht nachweisbar. In konventionell erhitzten Proben beobachtete Effekte auf die Aminosäuren werden als Auswirkung der höheren Wärmebelastung während der Behandlung dieser Proben interpretiert.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01611144
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...