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  • 1
    Electronic Resource
    Electronic Resource
    Guidelines for the diagnosis and interpretation of hepatic granulomas (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 25 (1994), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.1994.tb01320.x
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  • 2
    Electronic Resource
    Electronic Resource
    Localization of thromboxane synthase in human tissues by monoclonal antibody Tü 300 (1992)
    Springer
    Virchows Archiv 421 (1992), S. 249-254 
    Details
    ISSN: 1432-2307
    Keywords: Thromboxane ; Thromboxane synthase ; Immunohistochemistry ; Mononuclear phagocyte system ; Epithelia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Using the monoclonal antibody Tü 300 we localized thromboxane synthase, a secondary enzyme of the arachidonic acid cascade, employing the alkaline phosphatase anti-alkaline phosphatase method and indirect double labelling immunofluorescence in frozen sections of human tissues. Aside from platelets, the source of the antigen, all cells of the mononuclear phagocytic system were positive, including epithelioid cells and associated giant cells, starry sky macrophages, dendritic cells of T-cell areas, Langerhans cells and Kupffer cells. In addition, some epithelial cells such as epithelia of tonsillar crypts, reticular epithelia of the thymic cortex and ductular epithelia in liver, pancreas, female breast and salivary glands showed occasional focal reactivity for thromboxane synthase. We suggest that the mAb Tü 300 is a key marker for the macrophage system and the thromboxane generating system in normal and pathological conditions. It may detect functional activities of as yet unknown significance in some specialized epithelial cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01611182
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  • 3
    Electronic Resource
    Electronic Resource
    p53 anderbB-2 protein overexpression are associated with early invasion and metastasis in bladder cancer (1993)
    Springer
    Virchows Archiv 423 (1993), S. 329-334 
    Details
    ISSN: 1432-2307
    Keywords: Bladder neoplasm ; p53 ; erbB-2 ; Metastasis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Overexpression of p53 anderbB-2 was studied by immunohistochemistry in formalin-fixed tissue samples of 179 patients with transitional cell carcinoma of the urinary bladder. p53 immunostaining was strongly correlated with tumour stage (P〈0.0001). This was driven by a marked difference in p53 expression between pTa (37% positive) and pT1 (71%) tumours, while there was no difference between pT1 and pT2-4 tumours. Similarly, a strong overall association between p53 expression and grade (P〈0.0001) was driven by a marked difference between grade 1 (28%) and grade 2 tumours (71%), and there was no significant difference between grade 2 and grade 3 tumours. Surprisingly, the frequency oferbB-2 overexpression was higher in pT1 tumours (74%) than in either pTa (49%;P=0.0265) or pT2-T4 (56%;P=0.0645) tumours. Both p53 anderbB-2 expression was also associated with metastasis. Metastases were found in 77% of patients with p53 positive primary tumours, but in only 50% of the patients with p53 negative primary tumours (P=0.022). Metastases were found in 66% of patients witherbB-2 positive primaries, but in only 37% of theerbB-2 negative primaries (P=0.020). Of 32 patients with positivity for both p53 anderbB-2, 84% developed metastases, as compared to 49% of patients with positivity for either one or neither positive (P=0.002). We conclude that both p53 anderbB-2 over-expression are associated with early invasion in bladder cancer. Furthermore, p53 anderbB-2 may be important predictors for metastasis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01607144
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  • 4
    Electronic Resource
    Electronic Resource
    Diagnostic tools for differentiating pleural mesothelioma from lung adenocarcinoma in paraffin embedded tissue (1993)
    Springer
    Virchows Archiv 423 (1993), S. 493-496 
    Details
    ISSN: 1432-2307
    Keywords: Malignant mesothelioma ; Lung adenocarcinoma ; Immunohistochemistry ; Expert system ; Discriminant analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A panel of 14 antibodies (panepithelial antibody Lu-5, anti-keratin-18, anti-keratin-7, Ber-EP4, anti-Leu-M1, HEA-125, anti-carcinoembryonic antigen, anti-blood group-related antigens A, B, H, B72.3, antiplacental alkaline phosphatase, anti-vimentin and BMA-120), which have been evaluated for use in differentiating mesothelioma from lung adenocarcinoma, was applied to a group of 24 suspected mesotheliomas. Using the established qualitative, descriptive criteria derived from monovariate statistical analysis of the tumour control groups (definite mesotheliomas, adenocarcinomas), a definitive allocation was possible in only 25% of suspected cases. We therefore constructed two “expert systems”, based on multivariate discriminant analysis with either the ALLOC 80 program for ordinal data or a newly developed analysis program for binomial data. With these two systems diagnostic allocation of suspected mesotheliomas was improved to 75% and 79%. The use of binomial data (“positive” versus “negative”) in conjunction with the probability-based test system is of particular interest because the primary data are easy to record and the test results have a higher statistical probability.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01606540
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  • 5
    Electronic Resource
    Electronic Resource
    Diagnostic tools for differentiating between pleural mesothelioma and lung adenocarcinoma in paraffin embedded tissue. Part I: immunohistochemical findings (1993)
    Springer
    Virchows Archiv 423 (1993), S. 19-27 
    Details
    ISSN: 1432-2307
    Keywords: Malignant mesothelioma ; Lung adenocarcinoma ; Ber-EP4 ; BMA-120 ; Blood-group-isoantigen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Specimens of 27 histologically definite mesotheliomas and 34 proven adenocarcinomas were examined with a panel of 14 antibodies: pan-epithelial antibody Lu-5, anti-keratin-18, anti-keratin-7, Ber-EP4, anti-Leu-M1, HEA-125, anti-carcino-embryonic antigen (CEA), anti-blood group-related antigens (anti-BGR A, B, H), B 72.3, anti-placental alkaline phosphatase (PLAP), anti-vimentin and BMA-120 used to determine their value in the differentiation between pleural mesothelioma and lung adenocarcinoma. Lu-5, anti-cytokeratin-7 and -18, B 72.3 and PLAP reacted in a high percentage of cases with both mesothelioma and adenocarcinoma. Anti-CEA and anti-Leu-Ml did not react with any of the 27 mesotheliomas tested but showed a reaction in 75% (anti-CEA) and 66% (anti-Leu-M1) of the lung adenocarcinomas. Seventeen percent of the adenocarcinomas and 96% of the mesotheliomas showed a positive reaction with anti-vimentin. Ber-EP4 was demonstrated in all lung adenocarcinomas, but only in 2 mesotheliomas in a focal manner (7%). HEA-125 and anti-BGR A, B, H reacted with 83% (HEA-125) and 75% (anti-BGR A, B, H) of the lung adenocarcinomas. The statistical parameters, sensitivity and efficiency were estimated and a normogram for judging the diagnostic power of a single antibody for the differential diagnosis of mesothelioma versus adenocarcinoma was developed. According to this, Ber-EP4, HEA-125, anti-BGR A, B, H and anti-CEA were, in descending order, the most powerful discriminatory antibodies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01606427
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  • 6
    Electronic Resource
    Electronic Resource
    Cardiac myxomas: Immunohistochemical study of benign and malignant variants (1991)
    Springer
    Virchows Archiv 418 (1991), S. 485-491 
    Details
    ISSN: 1432-2307
    Keywords: Cardiac myxoma ; Immunohistochemistry ; Histogenesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Immunohistochemical investigation of 11 cardiac myxomas (CMs) including one malignant metastasizing CM showed a co-expression of epithelial (lu-5 and CAM 5.2), mesenchymal (vimentin) and neuroendocrine antigens (neuron-specific enolase) in all tumour cells. Factor VIII was found in the endothelial cells of capillaries only. In the subendocardium of fetal heart tissue close to the foramen ovale myofibroblasts reacting with the panepithelial antibody lu-5 were detected. We conclude that CMs are neoplasms that may develop from embryonic cell remnants.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01606497
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  • 7
    Electronic Resource
    Electronic Resource
    The localization of thromboxane synthase in normal and pathological human kidney tissue using a monoclonal antibody Tü 300 (1994)
    Springer
    Virchows Archiv 424 (1994), S. 69-74 
    Details
    ISSN: 1432-2307
    Keywords: Kidney ; Thromboxane ; Thromboxane synthase ; Tü 300 monoclonal antibody
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Thromboxane, excreted in the urine in increased amounts in glomerular, vascular and tubulo-interstitial diseases, is considered to originate from the kidney. The localization of thromboxane synthase, a key enzyme of arachidonic acid metabolism, was studied in the human kidney by immunohistology using the monoclonal antibody Tü 300. In the interstitial tissue dendritic reticulum cells surrounding the tubules expressed high concentrations of the enzyme. In glomeruli the enzyme was weakly expressed in podocytes. This was confirmed by co-localization with an antiserum directed to podocalyxin, a marker of the visceral epithelial cells. In the study of various kidney diseases, massive accumulation of thromboxane synthase containing cells was observed in interstitial diseases, whereas in glomerular diseases there were no differences from normal kidney; in a case of thrombotic microangiopathy podocytes exhibited an increase in thromboxane-synthase. The thromboxane-synthase positive infiltrating interstitial cells were shown by conventional light microscopy to be mononuclear phagocytic cells. The physiological sources of renal thromboxane are dendritic reticular cells and podocytes. In interstitial renal disease infiltrating cells of the monocyte/macrophage system constitute the major site of thromboxane synthesis. In glomerular disease, a characteristic alteration of thromboxane-synthase was not found.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00197395
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  • 8
    Electronic Resource
    Electronic Resource
    Das Normgewicht des Gehirns beim Erwachsenen in Abhängigkeit von Alter, Geschlecht, Körpergröße und Gewicht (1994)
    Springer
    Der Pathologe 15 (1994), S. 165-170 
    Details
    ISSN: 1432-1963
    Keywords: Schlüsselwörter Normales Hirngewicht ; Erwachsene ; Alter ; Geschlecht ; Körpergröße ; Gewicht ; Key words Normal brain weight ; Adults ; Age ; Sex ; Height ; Weight
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Based on more than 8000 autopsies of male and female patients without brain diseases the normal brain weight of adult males and females in relation to sex, age, body-weight, and body-height as well as Body Mass Index were calculated. The average brain weight of the adult male was 1336 gr; for the adult female 1198 gr. With increasing age, brain weight decreases by 2.7 gr in males, and by 2.2 gr in females per year. Per centimeter body height brain weight increases independent of sex by an average of about 3.7 gr. Body Mass Index is of minor importance and only relevant in males. Based on these data the independent variables, age and height, were for the first time combined in a nomogram for the calculation of brain weight. The mathematical functions were integrated in a computer program which facilitates the calculation of normal brain weights in individual cases.
    Notes: Zusammenfassung Anhand von über 8000 Autopsien von Patienten ohne Hirnkrankheiten wurden die Normgewichte der Gehirne für Männer und Frauen in Abhängigkeit von Alter, Körpergröße, Gewicht und Body Mass Index berechnet. Das Hirngewicht des erwachsenen Mannes beträgt im Durchschnitt 1336 g, das der erwachsenen Frau 1198 g. Pro Altersjahr nimmt das Hirngewicht beim Mann um ca. 2,7 g, bei der Frau um ca. 2,2 g ab. Pro cm Körpergröße nimmt das Hirngewicht bei beiden Geschlechtern um ca. 3,7 g zu. Den geringsten Einfluß auf das Hirngewicht hat der Body Mass Index, der praktisch nur bei Männern bedeutsam ist. Aus den unabhängigen Variablen, Alter und Körpergröße, wurde erstmals ein Nomogramm für das zu erwartende Hirngewicht konstruiert. Gleichzeitig wurden die Funktionen unter Berücksichtigung der wichtigsten Einflußgrößen in ein Computerprogramm integriert, das die Normgewichte errechnet und quantitative Aussagen über die Abweichung des Hirngewichts von der Norm im Einzelfall erlaubt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002920050040
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  • 9
    Electronic Resource
    Electronic Resource
    Studies on morphological outcome of cyclosporine-associated arteriolopathy after discontinuation of cyclosporine in renal allografts (1993)
    Springer
    Pediatric nephrology 7 (1993), S. 454-454 
    Details
    ISSN: 1432-198X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00857572
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  • 10
    Electronic Resource
    Electronic Resource
    Measurement of human nerve growth factor binding sites in brain and in peripheral tissues by a specific immunoprecipitation assay (1990)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 342 (1990), S. 251-257 
    Details
    ISSN: 1432-1912
    Keywords: Nerve growth factor receptor ; Immunoprecipitation ; Peripheral organs ; Central nervous system
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Using a monoclonal antibody against the human nerve growth factor (NGF) receptor (20.4 IgG), a specific immunoprecipitation assay for the quantitation of human NGF binding sites has been established. The procedure involves specific labeling of NGF receptors by covalent crosslinking to 125I-NGF with a carbodiimide reagent, and subsequent immunoprecipitation of the detergent-extracted 125I-NGF-receptor complexes with the 20.4 IgG. This two-site assay provides a specific method to measure NGF binding sites in peripheral tissues and central nervous system. Moreover, it allows analysis of the immunoprecipitated receptor species by sodium dodecyl sulfate polyacrylamide gel electrophoresis. The finding that specific NGF binding sites are expressed on human neuronal and nonneuronal tissues, including lymphoid tissues, indicates that NGF exerts a broader physiological function than originally ascribed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00169434
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