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  • 1
    Electronic Resource
    Electronic Resource
    Contact sensitization to 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one (MCI/MI) (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 24 (1991), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The frequency of positive reactions to 5-chloro-2-methyl-4-isothiazolin-3-one (MCI/MI) were studied at 22 European cntact dermatitis clinics over a period of 1 year. A total of 4713 patients participated. All the patients were patch tested with nickel sulphate, formaldehyde, paraben-mix, and MCI/MI 19.4% of the patients had positive patch tests to nickel, making this the most common allergen, 3% of the patients reacted to 100 ppm MCI/MI, while 2.6% reacted to formaldchyde and 1.1% to parabens. There was great variation in the frequency of MCI/MI sensitivity among the 22 centres. MCI/MI contact allergy was most common among women and in patients with facial dermatitis, while it was rarely seen in patients with dermatitis on the lower legs. There were no fluctuations in the number of positive patch tests to MCI/MI on a monthly basis when the results from all centres were combined. 117 of the 141 MCI/MI sensitized patients included in the study were retested 88% had positive patch tests when retested. 101 of the MCI/MI-sensitive patients participated in a double -blind, placebo-controlled product use test. This test showed that 31% of the MCI/MI-sensitive patients had a positive reaction to a MCI/MI-preserved product. Only a few patients reacted to a control product. It is concluded that the preservative MCI/MI is an important new contact allergen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0536.1991.tb01747.x
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  • 2
    Electronic Resource
    Electronic Resource
    European multicenter study of TRUE Test™, Panel 2 (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 22 (1990), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Panel 2 of the standardised, ready-to-apply patch test, the TRUE Test™, has been evaluated on 808 patients with suspected contact dermatitis. The patients were tested with 11 different allergens and the negative control, and compared with corresponding allergens in pet. (or aq.) in Finn Chambers® fixed with Scanpor® The TRUE Test™. Panel 2 and the control were applied symmetrically on the upper hack. Left Tight application of the respective test varied at random. Most tests were removed after 48 h and evaluated after 72 or 96 h. according to generally accepted recommendations. There were positive lest reactions lo all 11 allergens tested in the patient group. The concordance of positive reactions (1+, 2+, 3+) was 63% between TRUE Test™. Panel 2 and the control method. 17% of positive reactions occurred only with TRUE Test™. Panel 2 and 20% only with the compared method. Approximately 75% of all positive test reactions were explained by the patients' present or past history. Irritant questionable reactions occurred in the same frequency for the 2 methods Such reactions were recorded in less than l% of all patches applied No late reactions were recorded.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0536.1990.tb01570.x
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  • 3
    Electronic Resource
    Electronic Resource
    Effect of long-term PUVA treatment of psoriasis on the collagen and elastin gene expression and growth of skin fibroblasts in vitro (1990)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 123 (1990), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The proliferation rate, collagen metabolism and collagen and elastin messenger-RNA levels were studied in fibroblasts derived from patients who had received many courses of either systemic 8-methoxypsoralen or topical trioxsalen PUVA treatment. The proliferation rate of fibroblasts as measured by the incorporation of 3H-thymidine or by cellular division was decreased in those obtained from patients who had PUVA treatment as compared with controls. Collagen synthesis was slightly increased in the cells from PUVA-treated patients, but the relative collagen synthesis and the ratio between types I and III collagen were unchanged. The levels of collagen and elastin mRNAs were increased in fibroblasts derived from the PUVA-treated patients. No significant differences in histology or immunochemistry could be found in the biopsies taken from topical and systemic PUVA-treated patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1990.tb01479.x
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  • 4
    Electronic Resource
    Electronic Resource
    Specific IgE to reindeer epithelium in Finnish reindeer herders (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Allergy 46 (1991), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Reindeer herding is a major source of living for more than 4200 inhabitants in northern Finland. To determine the prevalence of allergic symptoms among reindeer herders clinical examinations and skin prick tests (SPT) with nine inhalant allergens were performed in 211 randomly selected men from 21 to 69 (mean 45) years. Specific IgE antibodies to reindeer epithelium (RE) and total serum IgE were evaluated in 99 herders, five persons who handled reindeer leather indoors, 21 atopic patients with cow allergy and another 20 subjects with specific IgE to other inhalant allergens. Positive SPT to RE was detected in one and specific IgE by using enzyme allergosorbent test (EAST) (≥ 0.8 PRU/ml) in seven herders. Specific IgE to RE was also demonstrated in one control. Using RAST inhibition a patient with cow allergy did not show cross-reactivity between cow and RE while another patient did. Thus, RE should be included in the allergy test panel when hypersensitivity to RE is suspected.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1398-9995.1991.tb00626.x
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  • 5
    Electronic Resource
    Electronic Resource
    Assessment of skin erythema by eye, laser Doppler flowmeter, spectroradiometer, two-channel erythema meter and Minolta chroma meter (1993)
    Springer
    Archives of dermatological research 285 (1993), S. 278-282 
    Details
    ISSN: 1432-069X
    Keywords: Skin colour ; Skin blood flow ; UVB erythema ; Immediate contact reactions ; Benzoic acid ; Methyl nicotinate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Visual grading, a laser Doppler flowmeter, a spectroradiometer, a two-channel erythema meter and a Minolta chroma meter were compared in the measurement of erythemas arising from immediate contact reactions produced either by 250 mM benzoic acid or 10 mM methyl nicotinate in petrolatum in an open application test or by ultraviolet irradiation. A good correlation between visual grading and objectively measured values was found for all the instruments, buth the laser Doppler flowmeter gave proportionally lower values for the ultraviolet erythemas than the skin reflectance meters, suggesting that these differ from erythemas induced by benzoic acid or methyl nicotinate. The laser Doppler flowmeter gave less repeatable results than other meters when measuring moderate and pronounced erythemas produced by ultraviolet irradiation. Measuring both the blood flow and the actual erythema may give more information about the reaction than either measurement system alone.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00371596
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