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  • 1990-1994  (7)
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  • 1
    Electronic Resource
    Electronic Resource
    Stable and strong expression of basic fibroblast growth factor in naevus cell naevus contrasts with aberrant expression in melanoma (1994)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 130 (1994), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary It has been proposed that basic fibroblast growth factor (bFGF) is an autocrine growth factor of melanoma cells, in contrast with normal melanocytes where bFGF acts as a paracrine growth factor. As this notion is mostly based on the different requirements for bFGF in cultures of benign and malignant pigment cells in vitro, we performed an immunohistochemical study to examine bFGF expression in vivo using paraffin sections from naevus cell naevi (NCN) and malignant melanoma (MM). All the NCN (n=7) showed strong and homogeneous expression of bFGF protein, whereas the primary MMs (n=5) showed heterogeneous expression, with a population of negative cells. Metastatic MMs (n=5) also showed heterogeneous expression, and had a greater population of negative cells. These results suggest that bFGF has some, as yet unidentitied, role in the growth of benign NCN, and that overexpression of bFGF is neither a prerequisite for melanoma genesis nor for progression to metastatic MM.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1994.tb02927.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The altered expression of α-smooth muscle actin in basal cell epithelioma and its surrounding stroma: with special reference to proliferating cell nuclear antigen expression and adenoid differentiation (1994)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 130 (1994), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary Altered expression of α-smooth muscle actin (α-SMA) is known to indicate the morphological, tumorigenic and immunological changes occurring in tumour and stromal cells. The purpose of this study was to analyse the dynamics of α-SMA expression in human basal cell epithelioma (BCE) cells and their surrounding stromal cells, in the process of differentiation towards cutaneous appendages such as hair, sebaceous, apocrine and eccrine glands. Using anti-α-SMA specific monoclonal antibody (MAb), 17 of 36 BCEs (47%) were shown to express α-SMA, despite the usual absence of α-SMA in all eukaryotic cells except muscle cells. Solid, adenoid and sclerosing types of BCE expressed α-SMA more frequently, and in greater amount, than cystic, keratotic and superficial types. Furthermore, the expression of α-SMA in BCE cells significantly paralleled the expression of proliferating cell nuclear antigen (PCNA) in these cells. Thus, the altered expression of α-SMA may reflect the growing properties of BCE cells under the specific cellular regulations for differentiation.In addition, we have found anti-α-SMA MAb-positive fibroblasts with smooth muscle differentiation (myofibroblasts) in desmoplastic stroma surrounding BCE nests in 13 of 36 cases (36%). Coincidental expression of α-SMA in both BCE cells and stromal cells was found in nine of the 13 cases (69%), indicating the possibility of the induction of myofibroblastic stromal changes in surrounding tissues by cytokines secreted from BCE cells [e.g. basic fibroblast growth factor (bFGF)-like factor].
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1994.tb02898.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    International Symposium: Skin Carcinogenesis in Man and in Experimental Models (1992)
    Springer
    Journal of cancer research and clinical oncology 118 (1992), S. 321-328 
    Details
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01208624
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Evaluation of interfacial properties in glass fibre-epoxy resin composites — reconsideration of an embedded single filament shear-strength test (1991)
    Springer
    Journal of materials science 26 (1991), S. 4663-4666 
    Details
    ISSN: 1573-4803
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract An embedded single-filament shear-strength test was employed to explore the effect of the reinforced interface on the fracture of single filaments in glass fibre-epoxy resin composites. The interfacial effect was evaluated not only by critical fibre length but also by the fracture process of an embedded single filament observed by applying tensile load to the composites. The mean fragment length, measured at different tensile stresses, decreased with an increase in stress and finally reached a value correlated with critical fragment length. Interfacial reinforcement by silane treatment affects the fracture process rather than the critical fibre length. The behaviour was examined in several factors, such as filament diameter, the tension of filament on the moulding of composites, and the scatter of the composites in mechanical properties. A useful method was proposed to exclude such scatter: specimens treated on a half-length of embedded filament were subjected to this test. The present method leads us to confirm that the reinforced interface has no effect on the critical fibre length, while it does promote the progress of the fracture.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00612403
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Collision-induced reactions of size-selected molecular cluster anions (1993)
    Springer
    The European physical journal 26 (1993), S. 223-225 
    Details
    ISSN: 1434-6079
    Keywords: 36.40 ; 34.90
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Collision-induced reactions of size-selected cluster anions, (CO2) n − and (N2O)nO− with He and Kr atoms were studied at collision energies from 0.1 to 2.0 eV (center-of mass) by means of a tandem mass-spectrometer equipped with a pair of octapole ion guides. The dominant process was evaporation of the constituent molecules from the parent cluster ion. The absolute cross section for the evaporation was measured as functions of the size of the parent cluster ion and the collision energy. The reaction was explained by collisional excitation of the parent cluster ion followed by its unimolecular dissociation. The observed cross sections which correspond to those for the collisional excitation agree with those calculated in terms of charge-induced dipole and induced dipole-induced dipole interactions between the parent cluster ion and the target atom. The distributions of the product ions resulting from the unimolecular dissociation were reproduced by a simple calculation based on RRK theory. In the collision of (CO2) n − , the cross sections for (CO2) 10 − and (CO2) 14 − were significantly small and their abundances in the product ion distributions were particularly large. These findings indicate that (CO2) 10 − and (CO2) 14 − are stable species. On the other hand, stable species in (N2O)nO− was found to be (N2O)5O−.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01429151
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Frequencies of breathing vibrations of nearly spherical Ar clusters calculated by molecular dynamics (1991)
    Springer
    The European physical journal 20 (1991), S. 161-162 
    Details
    ISSN: 1434-6079
    Keywords: 31.20 − d ; 36.40. + d
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The breathing vibration of Ar N cluster,N=13, 20, 25, 30 and 55, was investigated by use of the molecular dynamics method. The average distance $$(\bar r)$$ averaged over the positions of all Ar atoms with respect to the center of mass was calculated as a function of time and its frequency spectrum was derived by the Fourier transform analysis. The $$\bar r$$ value was proved to be a good index of the breathing vibration in comparison with the exact breathing vibration of an Ar dense sphere. The vibrational frequency thus estimated,f MD, was found to increase with the cluster sizen as expected.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01543963
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  • 7
    Electronic Resource
    Electronic Resource
    Collisional process involving atomic cluster ions (1994)
    Springer
    The European physical journal 31 (1994), S. 187-189 
    Details
    ISSN: 1434-6079
    Keywords: 36.40.+d
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Collision of Ar cluster ions, Ar n + (n=3−16), with He and Ne atoms was investigated by use of mass spectroscopic techniques. The cross sections for the production of Ar n′ + (n′〈n) were measured as functions of the size of the parent cluster ion and the collision energy (0.1–10 eV in the center-of-mass frame). These results were analyzed in the scheme of hard-sphere spectator collision with RRK theory. It was concluded that the reaction proceeds via collisional excitation of the parent cluster ion and following sequential loss of the constituent Ar atoms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01437834
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    Paper (German National Licenses)
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