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  • 1
    Electronic Resource
    Electronic Resource
    Linkage between O6-methylguanine-DNA methyltransferase (O6-MT) activity and cellular resistance to antitumour nitrosoureas in cultured rat brain tumour cell strains (1990)
    Springer
    Acta neurochirurgica 103 (1990), S. 62-66 
    Details
    ISSN: 0942-0940
    Keywords: O6-methyl-DNA methyltransferase (O6-MT) ; nitrosoureas ; nimustine (ACNU) ; ramustine (MCNU) ; glioma cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We have examined O6-methylguanine-DNA methyltransferase (O6-MT) activity of rat brain tumour cell strains with reference to cellular resistance to antitumour nitrosoureas, 1-(4-amino-2-methyl-5-pyrimidinyl) methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride (nimustine, ACNU) and methyl-6-[3-(2-chloroethyl)-3-nitrosoureido]-6-deoxy-α-D-glucopyranoside (ramustine, MCNU). The values of O6-MT activity were 52 and 160 fmol/mg protein extract in 9 L and C 6 rat brain tumour cells, respectively; while HeLa S 3 cells, as a methyl excision repair positive (Mer+) cell strain, revealed a rather high value of 488 fmol/mg. 9 L cells indicative of a low O6-MT activity showed 13 μM for ACNU and 18 μM for MCNU at a 10% survival dose (SD10), determined by a clonogenic cell assay as an index of cellular resistance. In contrast to this, C 6 cells revealed a SD10 value of 67 μM and 36 μM for ACNU and MCNU, respectively, indicating higher resistance than 9 L cells. HeLa S 3 cells showed the highest SD10 value as follows: 84 μM for ACNU and 73 μM for MCNU. The relationship between the O6-MT activity and the cellular resistance was almost linear, with relatively resistant cell lines exhibiting the higher levels of the O6-MT activity. This correlation between the O6-MT activity and the cellular resistance to nitrosoureas as ACNU and MCNU was not observed among other antitumour drugs, which included bleomycin (BUM), neocarzinostatin (NCS),cis-diamminedichloroplatinum (II) (CDDP), and etoposide (VP-16) in clinical use for brain tumour chemotherapy. This indicates that O6-MT activity can be an indicator of cellular resistance to antitumour nitrosoureas in the chemotherapy of brain tumours.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01420193
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  • 2
    Electronic Resource
    Electronic Resource
    Liquid-holding recovery of sister chromatid exchanges in UV-irradiated normal and xeroderma pigmentosum complementation groups A and F fibroblasts (1990)
    Springer
    Archives of dermatological research 282 (1990), S. 68-70 
    Details
    ISSN: 1432-069X
    Keywords: Xeroderma pigmentosum Complementation groups A and F ; Sister chromatid exchanges ; Ultraviolet light ; Liquid-holding
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00505648
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Synthesis of intermetallics for high temperature structural applications: (Mn5Si3)16H crystal structure (1991)
    Springer
    Journal of materials science 26 (1991), S. 3497-3502 
    Details
    ISSN: 1573-4803
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The Zr-Si system was chosen to study the potentiality of the (Mn5Si3)16H crystal structure for high temperature structural applications. A procedure was devised for the synthesis of intermetallics that have very high melting points. By hot isostatic pressing in a glass capsule, highly densified samples of Zr5Si3 were produced. Mechanical properties were measured. This compound is a good candidate for high temperature structural applications.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00557137
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  • 4
    Electronic Resource
    Electronic Resource
    Thermal conduction mechanism of aluminium nitride ceramics (1992)
    Springer
    Journal of materials science 27 (1992), S. 2627-2630 
    Details
    ISSN: 1573-4803
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract Extremely large grain size AIN ceramics were produced by HIP sintering at an ultra-high temperature of 2773 K without reducing the oxygen content in order to determine experimentally whether the factor controlling thermal conductivity is either grain boundaries or the internal structure of the grains. The room-temperature thermal conductivity of the HIPed AIN with a grain size of ∼40 μm was 155 Wm−1 K−1, and was almost equal to that of the normally sintered AIN with a grain size of 4 μm. Therefore, thermal conductivity at room temperature is independent of AIN grain size, or the number and amount of grain-boundary phase for reasonably well-sintered AIN ceramics. The calculated phonon mean free path of sintered bodies was 10–30 nm at room temperature, which is too small to compare with the AIN grain size. Consequently, it is shown that the thermal conductivity of sintered AIN is controlled by the internal structure of the grains, such as oxygen solute atoms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00540680
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    Paper (German National Licenses)
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