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  • 1990-1994  (4)
  • 1
    Electronic Resource
    Electronic Resource
    Increased assembly of cytoskeletal proteins associated with the transformation of human liver cells into fibroblast-like cells (1992)
    Springer
    Cellular and molecular life sciences 48 (1992), S. 495-497 
    Details
    ISSN: 1420-9071
    Keywords: Cytoskeletal proteins ; differentiation ; hepatocyte ; butyrate ; novobiocin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract A topoisomerase II inhibitor, novobiocin, and a deacetylase inhibitor, butyrate, synergistically transformed human liver cells into fibroblast-like cells. This morphological change was associated with an increased production of procollagen type III peptide and a simultaneous assembly of actin, tubulin, vimentin and cytokeratin. Novobiocin and butyrate had no marked effect on the phosphorylation state of cytokeratin proteins, but synergistically enhanced [3H]acetate uptake. From these results, it can be speculated that protein acetylation plays an important role in inducing the assembly of cytoskeletal proteins and the morphological transformation of human liver cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01928172
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The head crash induced by liquefaction of gases : 35th annual conference on magnetism and magnetic materials (1991)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 69 (1991), S. 5742-5744 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The most frustrating type of head crash is one that wipes out data on one track after thousands of hours of stable operation. Analysis of debris gives few clues as to its cause. This paper explains this type of head crash and identifies the liquefaction of organic gases on the taper section of the head slider as its primary cause. Both theoretical considerations and experimental results are presented.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.347907
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Bicuculline-induced blockade of neocortical rapid kindling suggesting facilitative GABAergic action on seizure development (1992)
    Springer
    Amino acids 3 (1992), S. 119-124 
    Details
    ISSN: 1438-2199
    Keywords: Amino acids ; Neocortex ; GABA ; Kindling ; Rabbits
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To investigate how GABAergic function affects seizure development, the effects of a GABA antagonist, bicuculline, on neocortical and hippocampal kindling were examined in chronically prepared rabbits. Kindling-inducing stimulations consisted of stimulus trains repeated at 5-min interstimulus intervals to produce so-called “rapid kindling”. The changes in after-discharge (AD) durations induced by each of 15 trials of stimulus trains per session were compared before and 30 min after i.p. injection of bicuculline solution (2 mg/kg) in each of three kindling groups consisting of 5 rabbits each, i.e. visual cortical, motor cortical and hippocampal kindling groups. In the visual cortex and to a less extent, the motor cortex kindling groups, the AD durations were shortened after bicuculline injection and did not show the progressive prolongation seen before the injection. In contrast, the hippocampal kindling group showed a further marked prolongation of the AD durations after the injection. The bicuculline-induced blockade of neocortical kindling suggests facilitative GABAergic action on seizure development, while the drug-induced enhancement of hippocampal kindling reflects the known inhibitory GABAergic action.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00806776
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    K252a: A new blocker of the cell-cycle at G1 phase in a human hepatoma cell line (1993)
    Springer
    Cellular and molecular life sciences 49 (1993), S. 876-880 
    Details
    ISSN: 1420-9071
    Keywords: K252a ; G1 block ; cell size ; c-myc ; albumin ; HuH7
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The administration of 200 nM K252a to HuH7 suppressed the proliferation of the cells almost completely. The uptake of [3H]thymidine was inhibited, and flow cytometry revealed only one peak at 2C on day 3 after treatment with 100 nM K252a. The expression of proto-oncogene c-myc was not reduced. Despite the blockage at G1, both the size of the cells and the amount of cell protein had increased by 4 times by day 3 after treatment with K252a, while the cells secreted albumin and α-fetoprotein into the medium as usual. These results show that K252a can increase the cell size of HuH7 without losing its function by blocking the cell cycle at G1 phase.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01952601
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    Paper (German National Licenses)
    Fulltext
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