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  • 1
    Electronic Resource
    Electronic Resource
    Clustering of perinatal markers of birth asphyxia and outcome at age five years (1994)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 101 (1994), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objectives In a cohort of term infants with cerebral depression at delivery, to investigate the association of perinatal signs of birth asphyxia, particularly abnormal fetal heart rate patterns in labour, acidaemia, and serious neonatal encephalopathy, with neurodevelopmental outcome at age five years.Design Five year follow up study of a birth cohort.Setting Regional maternity hospital.Subjects One hundred and eighty-four singleton infants with a 1 min Apgar score ≤ 3, born at term between January 1984 and September 1985.Main outcome measures Neonatal death, cerebral palsy, and scores on a battery of neurodevelopmental tests at age five.Results Seven infants had a cluster of perinatal signs suggestive of birth asphyxia; all included serious neonatal encephalopathy. Three of these infants died neonatally, three had spastic quadriparesis with profound developmental delay, and one was unimpaired at the age of five. Among the remaining infants, no association was found between severely abnormal fetal heart rate patterns in labour and scores on neurodevelopmental tests, or between acid–base status at delivery and test scores.Conclusions Birth asphyxia, identified by a cluster of abnormal perinatal signs, including serious neonatal encephalopathy, has a poor prognosis. If serious encephalopathy is not present, cerebral depression at birth preceded by abnormal fetal heart rate patterns in labour, or with acid–base derangement, is not predictive of later impairment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1994.tb11945.x
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  • 2
    Electronic Resource
    Electronic Resource
    Refined crystal structure of Acinetobacter glutaminasificans glutaminase–asparaginase (1994)
    Copenhagen : International Union of Crystallography (IUCr)
    Acta crystallographica 50 (1994), S. 826-832 
    Details
    ISSN: 1399-0047
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: The crystal structure of glutaminase–asparaginase from Acinetobacter glutaminasificans has been reinterpreted and refined to an R factor of 0.171 at 2.9 Å resolution, using the same X-ray diffraction data that were used to build a preliminary model of this enzyme [Ammon, Weber, Wlodawer, Harrison, Gilliland, Murphy, Sjölin & Roberts (1988). J. Biol. Chem. 263, 150–156]. The current model, which does not include solvent, is based in part on the related structure of Escherichia coli asparaginase and is significantly different from the structure of the enzyme from A. glutaminasificans described previously. The reason for the discrepancies has been traced to insufficient phasing power of the original heavy-atom derivative data, which could not be compensated for fully by electron-density modification techniques. The corrected structure of A. glutaminasificans glutaminase–asparaginase is presented and compared with the preliminary model and with the structure of E. coli asparaginase.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0907444994003446
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  • 3
    Electronic Resource
    Electronic Resource
    Serratia marcescens rpr gene sensitizes Escherichia coli wild-type, xth, and nfo strains to methyl methanesulphonate (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Molecular microbiology 4 (1990), S. 0 
    Details
    ISSN: 1365-2958
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: It is reported here that the rpr DNA repair gene of Serratia marcescens does not complement an Escherichia coli xth nfo AP endonuclease mutation for resistance to methyl methanesulphonate (MMS). Rather, rpr sensitized Escherichia coli wild-type, xth, and nfo strains to MMS. Also, it was found that rpr could not complement a triple tag alkA recA mutation in E. coli, indicating that there are limits to rpr complementing capabilities. It was determined that rpr gene dosage was not a factor in recA complementation. MMS sensitization of an E. coli wild-type strain, however, was directly related to rpr copy number. These data indicate that Rpr does not have an associated AP endonuclease activity, and that it is incapable of substituting for Tag I, Tag II, and RecA in a tag alkA recA background.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2958.1990.tb00634.x
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  • 4
    Electronic Resource
    Electronic Resource
    First operation of a photocathode radio frequency gun injector at high duty factor (1993)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 63 (1993), S. 2035-2037 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Tests of the electron beam injector for the Boeing/Los Alamos Average Power Laser Experiment have demonstrated first time operation of a photocathode radio frequency gun accelerator at 25% duty factor, exceeding previous photocathode operating parameters by three orders of magnitude. The macropulse format was 30 Hz and 8.3 ms with a micropulse frequency of 27 MHz. Average beam currents of up to 32 mA have been accelerated to 5 MeV for an average beam power of 160 kW. The macropulse peak current was 128 mA. The 32 mA average beam current exceeds previous cathode performance by a factor of 1000. Emittance measurements demonstrate excellent electron beam quality.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.110583
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  • 5
    Electronic Resource
    Electronic Resource
    Multisensory control of escape in the cockroach Penplaneta americana (1994)
    Springer
    Journal of comparative physiology 174 (1994), S. 13-26 
    Details
    ISSN: 1432-1351
    Keywords: Insects ; Antennae ; Toads ; Mice ; Mantids ; Spiders
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract 1. Interactions of cockroaches with 4 different predator species were recorded by videography. Some predators, especially spiders, struck from relatively short distances and usually contacted a cockroach prior to initiation of escape (Table 1, Fig. 3). This touch frequently occurred on an antenna. Cockroaches turned away from the side on which an antenna was touched. 2. We then measured the success of escape from predators for cockroaches with either cerci or antennae ablated. Only antennal removal caused a significant decrease in the success of escape from spiders (Fig. 5). 3. With controlled stimuli, cockroaches responded reliably to abrupt touch of antennae, legs or body (Fig. 6). Responses resembled wind-elicited escape: they consisted of a short latency turn (away from the stimulus) followed by running (Figs. 7, 8). However, lesions show that touchevoked escape does not depend on the giant interneuron system (Table 2). 4. Following section of one cervical connective, cockroaches continued to respond to touching either antenna, but often turned inappropriately toward, rather than away from, stimuli applied to the antenna contralateral to the severed connective (Table 3, Fig. 10). 5. For certain types of predators touch may be a primary cue by which cockroaches detect predatory attack. Descending somatosensory pathways for escape are distinct from the GI system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00192002
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  • 6
    Electronic Resource
    Electronic Resource
    ATP-sensitive potassium channels counteract anoxia in neurones of the substantia nigra (1991)
    Springer
    Experimental brain research 84 (1991), S. 355-358 
    Details
    ISSN: 1432-1106
    Keywords: Substantia nigra ; Pars compacta neurones ; Cyanide ; KATP channel ; Tolbutamide ; Low threshold calcium conductance ; Parkinson's disease ; Guinea pig
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The ATP-sensitive potassium channel (KATP channel) is a unique ionophore in that it appears to reflect cell metabolism. In the brain, the highest density of binding sites for the KATP channel is the substantia nigra. To evaluate the role of the KATP channel in this key brain area for motor control, we used exposure to cyanide to lower intracellular ATP and thereby mimic anoxia and ischemia. Treatment with cyanide caused the activation of a potassium current in a sub-population of nigral neurones with distinct pharmacological and electrophysiological properties. The response to cyanide was abolished by the sulphonylurea tolbutamide, a potent blocker of the KATP channel. These results suggest that in the substantia nigra, the KATP channel plays a pivotal role in normal mechanisms of neuronal homeostasis in response to anoxia and ischaemia. The significance of these findings for our understanding of the cellular mechanisms in Parkinsonian degeneration is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00231456
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  • 7
    Electronic Resource
    Electronic Resource
    Helicobacter pylori infection in children (1994)
    Springer
    Digestive diseases and sciences 39 (1994), S. 1488-1492 
    Details
    ISSN: 1573-2568
    Keywords: Helicobacter pylori ; children ; symptomatology ; gastritis ; ulcers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Helicobacter pylori is an established cause of chronic-active gastritis in both adults and children. However, it is unclear whetherH. pylori causes specific clinical symptoms. Therefore, the spectrum of clinical symptoms associated withH. pylori infection was studied in consecutive symptomatic children undergoing diagnostic endoscopy at two pediatric centers, using a structured questionnaire. In Toronto, Canada, 86 of 97 eligible children were enrolled into the study and in Limerick, Ireland, 24 of 29 were enrolled. The frequency of biopsy-confirmedH. pylori infection in Limerick, 16 of 24 (67%), was fivefold higher than in Toronto, 11 of 86 (13%,P=0.0001). The two study populations were comparable in clinical presentation and duration of symptomatology and did not differ in age (11.9±3.5 and 11.6±2.0 years, respectively). Within both study populationsH. pylori infection was not associated with specific clinical symptomatology, including duration of abdominal pain, location of pain, and history of melena or vomiting.H. pylori was positively associated with hematemesis in the Limerick group. These findings demonstrate thatH. pylori infection in children is not associated with specific clinical symptomatology across varying geographical locations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02088053
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  • 8
    Electronic Resource
    Electronic Resource
    Foreword (1994)
    Springer
    Hydrobiologia 290 (1994), S. vii 
    Details
    ISSN: 1573-5117
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00008944
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  • 9
    Electronic Resource
    Electronic Resource
    Euhydrophyte communities of the River Nile and its impoundments in Egyptian Nubia (1991)
    Springer
    Hydrobiologia 218 (1991), S. 35-47 
    Details
    ISSN: 1573-5117
    Keywords: macrophytes ; community ecology ; River Nile ; Egypt
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The River Nile and its two impoundments, the Aswan Reservoir and Lake Nasser, are important habitats for submerged and floating-leaved freshwater macrophytes (euhydrophytes) in the desert region of Egyptian Nubia. Ordination and classification analysis of survey data collected during the period 1980–1986 suggested that the Aswan High Dam forms a man-made vegetational boundary, delineating two basic macrophyte community types. In Lake Nasser a community dominated by Najas spp. is present. In the Aswan Reservoir and the R. Nile downstream of the old Aswan Dam the euhydrophyte community is dominated by a Potamogeton crispus — Ceratophyllum demersum association. Differences between the two community types appear to be related to differences in physical factors (e.g. water level fluctuation and flow regime), and water chemistry, to phenological factors, and to the differing successional ages of the macrophyte communities of the Nile system upstream and downstream of the Aswan High Dam. There is some evidence for depth zonation of the submerged macrophyte community in both lake and river habitats. Strategy analysis of the euhydrophyte communities present upstream and downstream of the High Dam, over the period 1963–89, indicated that successful established-phase strategy types were similar on both sides of the dam. In the long term there seems little to prevent euhydrophyte species at present confined to below the High Dam from crossing this boundary to colonise Lake Nasser.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00006416
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  • 10
    Electronic Resource
    Electronic Resource
    Freshwater and wetland plant communities of Loch Lomond (1994)
    Springer
    Hydrobiologia 290 (1994), S. 63-74 
    Details
    ISSN: 1573-5117
    Keywords: aquatic vegetation ; wetland vegetation ; Loch Lomond ; lake ecology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Information on the aquatic and wetland vegetation of Loch Lomond, Scotland, is summarised for the period 1957–90. Aquatic macrophyte growth is estimated to occupy about 1% of the loch's total surface area, being limited to the 0–10 m euphotic zone, and probably excluded from much of this area by wave disturbance and unsuitable substrates. Aquatic vegetation is however abundant in sheltered bays and less-exposed shorelines, particularly in the South Basin of the loch. Although Littorella uniflora (L.) Aschers is the commonest, ubiquitous, submerged plant of the loch, three separate euhydrophyte communities have been identified within the loch. One of these is characterised by abundant stands of Elodea canadensis Michx., which appears to have invaded Loch Lomond some time between 1967–88, and has rapidly spread throughout the loch.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00008954
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