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  • 1990-1994  (8)
Material
Years
Year
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 152 (1993), S. 387-388 
    ISSN: 1432-1076
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 152 (1993), S. 462-466 
    ISSN: 1432-1076
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 149 (1990), S. 822-824 
    ISSN: 1432-1076
    Keywords: Clinical studies ; Study design
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 153 (1994), S. 467-468 
    ISSN: 1432-1076
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Infection 18 (1990), S. 100-100 
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical microbiology & infectious diseases 9 (1990), S. 697-699 
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The in vitro activity of cilofungin (LY121019), a new semi-synthetic antifungal agent was evaluated. Potent activity was seen againstCandida albicans andCandida tropicalis, with almost identical MIC and MFC results, whereas no activity was seen against any isolates ofCandida parapsilosis or threeAspergillus spp. However, MICs were dependent on medium and test conditions chosen. It is concluded that cilofungin has good activity against some medically important yeasts in vitro, and that its in vitro activity depends on the method used.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical microbiology & infectious diseases 9 (1990), S. 832-835 
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In a model of bronchopulmonary aspergillosis terbinafine did not improve survival of experimental animals in doses up to 80 mg/kg/day despite adequate lung concentrations. Pretreatment and aerosolization of the compound were also ineffective. Terbinafine was markedly less active in vitro when serum was used instead of Yeast-Nitrogen-Glucose-broth. It is concluded that a lack of bioavailability in the presence of serum may explain the lack of activity of terbinafine in experimental aspergillosis.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Infection 21 (1993), S. 89-92 
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Inzidenz von ZNS-Shuntinfektionen und damit verbundenen Risikofaktoren wurde durch Auswertung von Krankenakten untersucht. Zwischen 1986 und 1989 wurden 350 Shunt-Operationen durchgeführt, wobei 273 Shunts ventrikuloperitoneal und 75 ventrikuloatrial plaziert wurden. Bei 25 Patienten kam es während eines mittleren Beobachtungszeitraumes von 20 Monaten zu 28 Shuntinfektionen (8 %). Für 204 Patienten konnte die Nachbeobachtungszeit bis September 1992 ausgedehnt werden, weitere Infektionsfälle wurden in dieser Gruppe nicht beobachtet. In 24 Fällen (85,7 %) konnte ein ursächlicher Erreger isoliert werden. Bei den Erregern handelte es sich um grampositive Kokken in 22 Fällen (78,6 %) und um gramnegative Stäbchen in zwei Fällen. Hauptsymptome und -Befunde waren Fieber, Shuntdysfunktion und meningeale Reizerscheinungen sowie Bauchschmerzen (letztere ausschließlich bei VP-Shunts). Bei 24 Infektionsfällen wurde der Shunt sofort entfernt und eine antibiotische Therapie begonnen, in den übrigen Fällen erfolgte ausschließlich eine antibiotische Therapie. Ursache des Hydrozephalus, Shuntlage, perioperative Antibiotikagabe, Alter und Geschlecht eines Patienten waren nicht mit einem erhöhten Infektionsrisiko assiziiert, jedoch ergab sich ein Trend, der ein erhöhtes Infektionsrisiko mit der Operationsdauer zeigte. Die Infektionsrate lag bei 13,6% für eine Operationsdauer von 〉90 Minuten, während sie bei 5,2 % für Eingriffe mit einer Dauer von 〈30 Minuten lag.
    Notes: Summary The incidence of shunt infections and possible risk factors was investigated by chart analysis. From 1986 to 1989 350 shunt procedures were performed including 273 ventriculoperitoneal shunts and 75 ventriculoatrial shunts. Twenty-eight infectious episodes (8%) occurred in 25 patients during a median follow-up time of 20 months. For 204 patients the follow-up time could be prolonged until September 1992. In these patients no infectious episodes occurred in the extended observation period. In 24 cases (85.7%) a causative organism could be isolated. The infecting organisms were gram-positive cocci in 22 cases (78.6%) and gram-negative bacilli in two cases. The main signs and symptoms were fever, shunt malfunction and meningeal irritation, and with VP-shunts only, abdominal pain. Twenty-four infectious episodes were treated with antibiotics and immediate removal of the shunt. The remaining were managed with antibiotics only. The risk for shunt infection did not correlate with age or sex of patients, nor with the etiology of hydrocephalus, type of shunt implanted or perioperative antibiotic prophylaxis. However, a trend showing a higher risk for shunt infections with prolonged operation time was noticed. The infection rate was 13.6% for an operation lasting more than 90 minutes versus 5.2% for procedures of less than 30 minutes' duration.
    Type of Medium: Electronic Resource
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