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  • 1
    Electronic Resource
    Electronic Resource
    Synthesis of Specific Proteins in Trophic Factor-Deprived Neurons Undergoing Apoptosis (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 62 (1994), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Apoptosis, also known as programmed cell death, is a mechanism used by different tissues to regulate their cell content. In the nervous system, this process is supposed to adjust the final number of neurons to the number of the target cells they are innervating. The demonstration that, in several systems in vitro and in vivo, neuronal apoptosis can be prevented by inhibiting RNA or protein synthesis suggests that an activation of gene expression is required in the cells that are going to die. The genes involved and their products, named “killer proteins”, are not known in the superior vertebrates. In order to identify such proteins, we have used and characterized an in vitro model consisting of neurons derived from 8-day-old embryonic chicken ciliary ganglia. RNA and protein synthesis inhibitors can prevent the death of these neurons when they are deprived of trophic support. Comparing the synthesis of proteins in trophic-supported neurons with that in trophic-deprived neurons by the use of two-dimensional polyacrylamide gel electrophoresis, we have observed that several proteins were overexpressed reproducibly in the apoptotic cells. We found that all these proteins are localized in the nucleus, suggesting that they may be transcription regulators.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.1994.62041468.x
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  • 2
    Electronic Resource
    Electronic Resource
    Localization of basic fibroblast growth factor, a mitogen and angiogenic factor, in human brain tumors (1990)
    Springer
    Acta neuropathologica 79 (1990), S. 418-423 
    Details
    ISSN: 1432-0533
    Keywords: Fibroblast growth factor (FGF) ; Basic FGF ; Angiogenesis ; Brain tumors ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Fibroblast growth factor (FGF) is a potent angiogenic factor and a mitogen for a variety of mesoderm-and neuroectoderm-derived cell types (e.g., fibroblasts, endothelial cells, astrocytes, oligodendrocytes). After application of a monospecific polyclonal antiserum, we localized basic FGF on frozen sections of 73 human brain tumors using immunohisto-chemistry. FGF was present in a variable number of tumor cells (16/16 astrocytomas, 5/5 ependymomas, 0/3 benign and 4/7 anaplastic oligodendrogliomas, 11/12 glioblastomas, 11/11 meningiomas, 6/6 neurilemmomas, 0/3 pituitary adenomas, 2/2 choroid plexus papillomas, 0/1 neurocytoma, 2/2 benign fibrous histiocytomas, 2/5 metastatic carcinomas). FGF was detected in vascular cells of 59 tumors and in fibroblasts of connective tissue stroma from all papillomas and metastases. These results tend to indicate FGF involvement in the malignant progression of gliomas due to an autocrine or paracrine action. Histopathological aspects of malignant gliomas (e.g., pseudopalisading or pathological vessels) could be related to FGF activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00308718
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    Paper (German National Licenses)
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