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Doping profile control and two-dimensional electron gas formation by Si diffusion into III-V compounds (1994)

Matsushita, Shigeharu ; Terada, Satoshi ; Fujii, Emi ; [et al.]

[S.l.] : American Institute of Physics (AIP)

Journal of Applied Physics 76 (1994), S. 7300-7304

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ISSN: 1089-7550

Source: AIP Digital Archive

Topics: Physics

Notes: The doping characteristics of Si-diffused III-V compounds have been investigated using fully dielectric diffusion sources consisting of undoped SiOx/SiN double-layered films prepared by plasma-enhanced chemical-vapor deposition. It is demonstrated that the rectangular-shaped carrier concentration profiles resulting from the Si diffusion in GaAs can be controlled by varying the deposition parameters of the SiOx/SiN films, i.e., the N2O flow rate in the SiOx deposition, the SiOx film thickness, and the NH3 flow rate in the SiN deposition. It is explained that the profile variations are determined by the quantity of an excess of Si in the SiOx bottom film and the outdiffusion rate of Ga and/or As from GaAs. Furthermore, the Si diffusion experiments are carried out in AlxGa1−xAs, and the formation of a two-dimensional electron gas with a Hall mobility of 5060 cm2/V s at 300 K and 97 500 cm2/V s at 77 K is achieved by diffusing Si into an undoped GaAs/Al0.22Ga0.78As heterostructure. © 1994 American Institute of Physics.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1063/1.358017

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Interleukin-6 is antiproliferative to a mouse hybridoma cell line and promotive for its antibody productivity (1992)

Makishima, Fusao ; Terada, Satoshi ; Mikami, Tadashi ; [et al.]

Springer

Cytotechnology 10 (1992), S. 15-23

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ISSN: 1573-0778

Keywords: antibody productivity ; growth suppression ; hybridoma ; interleukin-6 ; specific productivity

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine , Process Engineering, Biotechnology, Nutrition Technology

Notes: Abstract Monoclonal antibody production by hybridoma cells at moderately slowed growth states would be favorable for commercial scale production since cells can devote their resources to performing the differentiated function, immunoglobulin production. We found that a purified recombinant human interleukin-6, which had been reported to support or stimulate proliferation of B cell hybridoma/plasmacytoma cells, suppressed growth of a hybridoma cell line in serum-free medium. In the presence of the interleukin, the growth-suppressed cells were viable for remarkably long periods in batch culture, and after removal of the interleukin from the culture medium, they started to proliferate at their normal growth rate. As the concentration of the interleukin increased in the culture, the growth rate decreased and the specific antibody productivity (antibody production rate per cell) increased to 5-fold of control at 10 U ml−1 (2 ng ml−1) of the interleukin.