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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Macromolecules 18 (1985), S. 1410-1418 
    ISSN: 1520-5835
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Macromolecules 18 (1985), S. 131-138 
    ISSN: 1520-5835
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 109 (1987), S. 7922-7923 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 44 (1988), S. 898-900 
    ISSN: 1420-9071
    Keywords: Fetal brain cells ; ethanol ; corticosterone ; dexamethasone ; choline acetyltransferase ; acetylcholinesterase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary In the presence of ethanol, corticosterone and dexamethasone inhibit choline acetyltransferase and acetylcholinesterase activities in cultured fetal brain cells of the rat. These results suggest that corticosteroids may have an important influence on the activity of cholinergic enzymes in the fetal brain and may antagonize the effects of ethanol in this setting.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-0568
    Keywords: Key words Epithelial-mesenchymal interactions ; Chick embryo ; Homeobox-containing gene ; Facial morphogenesis ; Facial defect
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Spatially-restricted expression domains of Msx 1 and Msx 2 in the developing chick face suggest that they may play a role in epithelial-mesenchymal interactions governing outgrowth of facial primordia. Retinoid application to developing chick faces reproducibly inhibits upper beak outgrowth but the lower beak is unaffected. In the normal face, high levels of Msx gene transcripts in upper and lower beak primordia correlate with regions of outgrowth. Following retinoid treatment, Msx 1 and Msx 2 transcripts are rapidly down-regulated in upper beak primordia where outgrowth is inhibited, but remain largely unchanged in lower beak primordia, where outgrowth is unaffected. Decreases in gene expression precede retinoid-induced morphological changes in the upper beak, suggesting that Msx gene products are involved in mediating the effect of retinoids on facial development.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-0509
    Keywords: Key words: Kidney, abscess〈+〉—〈+〉Kidney, infection〈+〉—〈+〉Kidney, magnetic resonance imaging〈+〉—〈+〉Kidney, computed tomography.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Purpose: To determine the appearance of renal abscesses on gadolinium-enhanced magnetic resonance (MR) images, we reviewed 12 MR studies of eight patients with renal abscesses. These findings were compared with findings on other imaging modalities. Methods: Eight patients underwent 12 MR studies at 1.5 T, including T1-weighted gradient echo and fat-suppressed spin echo pre- and post-Gd-DTPA enhancement. Two radiologists retrospectively reviewed the MR images and compared MR findings to the findings on contrast-enhanced computed tomography (CECT) in five patients, noncontrast computed tomography (NCCT) in two patients, and ultrasound in all patients. Results: On contrast-enhanced MR images, renal abscesses were clearly depicted as heterogeneously low-signal-intensity lesions. Four patients had solitary abscesses, and four had multiple abscesses. Prominent perinephric inflammatory stranding was observed in six patients and was best shown on gadolinium-enhanced T1 fat-suppressed images. CECT findings were comparable to contrast-enhanced MR images, although contrast resolution was less on CECT images in all cases. Renal abscesses were poorly shown on NCCT and ultrasound images. Conclusion: Renal abscesses are clearly shown on gadolinium-enhanced MR images as low-signal-intensity lesions associated with prominent perinephric inflammatory strands. In this study, NCCT and ultrasound studies are poor at defining abscesses. Despite lesser contrast resolution of CECT versus MRI, the findings in cases of renal abscesses are similar. In patients with elevated serum creatinine, iodine contrast allergy, or the need for serial exams, MRI may be the best imaging technique to evaluate renal abscesses.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-0509
    Keywords: Kidney ; MR, 81.1214 ; Kidney, neoplasm, 81.31, 81.21 ; Magnetic resonance (MR), contrast enhancement
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background This study evaluates the ability of MRI to stage transitional cell carcinoma of the upper urinary tract. Methods Nine patients who had transitional cell carcinoma of the upper urinary tract detected by other imaging modalities underwent MRI examination at 1.5 T. Imaging included pre- and postgadolinium-DTPA T1-weighted images (9 patients) pre- and postgadolinium chelate T1-weighted fat-suppressed spin echo (7 patients). Postcontrast images were acquired prior to the presence of gadolinium within the collecting system (〈2 min postcontrast), intermediate (2.5–8 min), and late (〉10 min) postcontrast. Images were prospectively interpreted and lesion staging was determined. Correlation with histopathology was obtained in all cases. Results Transitional cell cancers were demonstrated in 9/9 patients, and tumors ranged in size from 2 to 8 cm (mean = 3.8 cm) in one dimension. Correct tumor staging was performed in 8/9 patients. The staging error in one case occurred because direct tumor extension into the renal parenchyma was not detected. Conclusions The results of this preliminary study show that MRI stages transitional cell cancers relatively well; however, MRI is not able to detect superficial invasion of renal parenchyma.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract We studied the early life history of diadromous gobies in Dominica, West Indies, from May 1989 to May 1991, emphasising Sicydium punctatum Perugia. The transition of newly hatched larvae from upriver nest sites to the sea was studied in laboratory experiments. Newly hatched larvae are negatively buoyant but avoid settling to the bottom by active swimming during drift to the sea. Laboratory experiments evaluated salinity preferences and effects on swimming endurance. Larvae in haloclines actively selected low to intermediate salinities. Initially (0 to 5-d post-hatch), larvae minimized exposure to salinities 〉10 ppt, but later (5 to 8-d) occupied increasingly saline water. Larvae in no-choice freshwater or seawater treatments ceased activity at 4 to 5 d, but in haloclines larvae remained active up to 8 d post-hatch. Salinities 〈10 ppt are important for early survival of sicydiine gobies. Implications for larval survival and transport are discussed.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Experiments were conducted in the autumn and winter of 1992/93 to examine habitat use by juvenile (age 0+) Atlantic cod, Gadus morhua L., before, during and following exposure to a passive or actively foraging predator (age 3+ cod). Experiments presented groups of juvenile cod (n=5 fish/group) with one of two combinations of three substrates; (1) gravel, sand, and a patch of artificial kelp (“kelp”), or (2) cobble, sand, and kelp. Cobble is known to provide juvenile cod with a refuge from predation. Kelp was used to test the hypothesis that juvenile cod associate with fleshy macroalgae in nature because of the safety it provides from predators. There was little difference in habitat use by juvenile cod before, during or following exposure to a passive predator. Under these conditions, juvenile cod appeared to prefer finer grained mineral substrates and avoided the kelp. The extent of the juvenile response to a passive predator was to avoid the predator's location in the experimental tank. In contrast, juvenile cod showed a significant shift in habitat use when exposed to an actively foraging predator, hiding in cobble or, when cobble was not available, in kelp. Use of both these habitats resulted in a significant reduction in predation risk to the juvenile cod. Our results suggest that: (1) an association with kelp provides safety from predation to juvenile cod, and (2) juvenile cod are capable for assessing the risk a predator represents and adjust their response accordingly.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract During early development in fish, phospholipase A2 (EC 3.1.1.4) regulates membrane lipid modifications, which relates to changes in environmental conditions and provision of fatty acids required for metabolic energy substrates and prostaglandin biosynthesis. A method to analyze phospholipase A2 in rat tissues has been modified to measure its activity in embryonic Atlantic halibut (Hippoglossus hippoglossus L.). Egg and embryo samples were collected during the 1994 spawning season. Enzyme activity was undetectable at fertilization but in 10-d embryos was 230 pmol mg−1 h−1 (at 20 °C) and increased by ∼120% at hatch (17-d). Significant alterations in the fatty acid composition of important phospholipids, phosphatidylcholine (PC) and phosphatidylethanolamine (PE), were also observed. The content of some critical polyunsaturated fatty acids, and the ratio of unsaturated/saturated fatty acids, declined significantly over development. Acyl-chain restructuring mediated through the activity of phospholipase A2, coupled with other observed lipid changes (significant increases in the PC/PE ratio and cholesterol content), would produce a decreased fluidity of membranes during embryonic development, coinciding with the predicted upward movement of larvae in the water column. Arachidonic acid (20:4n-6) removed from PE could serve as a precursor for biosynthesis of 2-series prostaglandins, and eicosapentaenoic acid (20:5n-3) from PC is a likely source for other prostaglandin types. Despite removal of polyunsaturated fatty acids, there was an overall increase in lipid and fatty acid concentration, which can be attributed to amino acid catabolism during early developmental stages.
    Type of Medium: Electronic Resource
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