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  • 1
    Electronic Resource
    Electronic Resource
    Online First publication (1999)
    Springer
    Journal of molecular medicine 77 (1999), S. 455-455 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001090050398
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  • 2
    Electronic Resource
    Electronic Resource
    The Journal of Molecular Medicine: tradition, continuity, and renaissance (1995)
    Springer
    Journal of molecular medicine 73 (1995), S. 1-3 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00203612
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  • 3
    Electronic Resource
    Electronic Resource
    Induction of cardiac angiotensin I-converting enzyme with dietary NaCl-loading in genetically hypertensive and normotensive rats (1995)
    Springer
    Journal of molecular medicine 73 (1995), S. 243-248 
    Details
    ISSN: 1432-1440
    Keywords: Angiotensin I-converting enzyme ; Gene expression ; Sodium chloride ; Heart ; Inbred rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We have recently shown that the angiotensin I converting enzyme (ACE) gene is linked to NaCl-loaded blood pressure in the stroke-prone spontaneously hypertensive rat (SHRSP), and that high-NaCl loading selectively stimulates ACE in the aorta of SHRSP but not in normotensive Wistar-Kyoto (WKY) rats. We therefore investigated the relationship between cardiac ACE and the development of hypertension and left ventricular hypertrophy in response to normal- and high-NaCl diet in these rats. ACE mRNA and ACE activity were measured in left ventricular tissue after completion of hemodynamic characterization of the animals. While SHRSP rats increased blood pressure (P〈0.0001) and heart rate (P〈0.005) in response to high NaCl, blood pressure remained unchanged in WKY. Similarly, relative left ventricular weight increased only in SHRSP after high NaCl (P〈0.002). A significant two- to threefold increase of cardiac ACE mRNA and fourfold stimulation of ACE enzyme activity in response to high NaCl was found in both WKY and SHRSP rats (P〈0.005). The induction of ACE gene expression was significantly more pronounced in SHRSP compared to WKY (P〈0.02), whereas no significant strain differences in left ventricular ACE activity were found after either normal- or high-NaCl diet. Thus, arterial blood pressure and left ventricular weight remained unchanged in the WKY rats despite the activation of left ventricular ACE activity after high-NaCl exposure. These results demonstrate that left ventricular ACE activity is equally upregulated in response to high-NaCl in the normotensive and hypertensive strain, independently from the development of hypertension. We conclude that the pretranslational induction of left ventricular ACE with high-NaCl loading may be important both for the regulation of cardiac angiotensins and kinins and for local therapeutic ACE inhibition in the heart during high-salt status.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00189924
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  • 4
    Electronic Resource
    Electronic Resource
    Electrolyte intake and blood pressure: A study in contradictions and controversy (1985)
    Springer
    Journal of molecular medicine 63 (1985), S. 788-792 
    Details
    ISSN: 1432-1440
    Keywords: Sodium ; Calcium ; National Health and Nutrition Examination Survey (NHANES) ; Hypertension
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The widely accepted recommendation that hypertensive subjects benefit from a reduction of sodium intake has lately been challenged by a number of publications. From one analysis of the First National Health and Nutrition Examination Survey (NHANES) in the USA, the conclusion was reached that hypertension was associated more frequently with low nutritional sodium intake and low calcium intake. Other authors analysing the same data but using different criteria and statistical methods did not confirm such conclusions. The criticisms of epidemiological data concerning the relationship between salt intake and hypertension include frequently inconsistent definition of hypertension, failure to consider methodological uncertainties in the measurement of salt intake and excretion and inadequate control of confounding variables such as age, race, sex, body mass index and lifestyle. The claimed link between nutritional calcium and blood pressure is completely unclear and needs careful investigation. A reduction of sodium intake from the present day excessive amounts to moderate intakes of 3–6 g per day is still recommended in order to prevent the establishment of high blood pressure, to reduce hypertensive blood pressure levels or to reduce the doses of antihypertensive drugs. With mild hypertension being the main problem of high blood pressure management, further research is necessary to place dietary intervention in the non-pharmacological treatment of hypertension on a firmer, more rational footing.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01732282
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  • 5
    Electronic Resource
    Electronic Resource
    Atrial natriuretic factor—a circulating hormone stimulated by volume loading (1985)
    [s.l.] : Nature Publishing Group
    Nature 314 (1985), S. 264-266 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The rat synthetic peptides used here were the 21-amino acid atriopeptin I (AP I), the 23-amino acid atriopeptin II (APII) and the 24-amino acid atriopeptin III (APIII)8. To obtain antibodies, New Zealand White rabbits were injected with AP II coupled to bovine thyroglobulin. AP III, which ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/314264a0
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  • 6
    Electronic Resource
    Electronic Resource
    Angiotensinogen gene expression in extrahepatic rat tissues: Application of a solution hybridization assay (1988)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 338 (1988), S. 327-331 
    Details
    ISSN: 1432-1912
    Keywords: Angiotensinogen gene expression ; Solution hybridization ; pSPT18 Riboprobe
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Angiotensin II has numerous biological effects in a hitherto unsuspected variety of tissues. The generation of angiotensin in tissue requires the local presence of its high molecular weight precursor angiotensinogen and is best tested by investigating angiotensinogen gene expression. A quantitative solution hybridization assay for rapid and sensitive measurement of angiotensinogen mRNA was therefore established to study the extrahepatic expression of the angiotensinogen gene. We used a 714 bases BamHI angiotensinogen cDNA fragment cloned into vector pSPT18 and developed a sensitive and rapid assay with a detection limit of 0.5 pg RNA. Quantification of angiotensinogen mRNA from male Sprague-Dawley rats resulted in the following tissue levels (n = 10 for all tissues, except pituitary where n = 5), was expressed as fg mRNA per jig total RNA, in descending order: liver (9950), hypothalamus (6050), midbrain (4450), brainstem (3950), total brain (2325), aorta (625), kidney (338), adrenal gland (170), and heart atrium (140). The high sensitivity of the assay in addition also allowed for the first time measurement of angiotensinogen mRNA in the low gene expression tissues pituitary (70), heart ventricle (30), and testis (30). This assay will allow detailed studies on the regulation of tissue angiotensinogen and the pathophysiological role of the tissue renin angiotensin systems.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00173408
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  • 7
    Electronic Resource
    Electronic Resource
    Decreased renal haemodynamic response to inhibition of nitric oxide synthase in subtotally nephrectomized rats (1995)
    Springer
    Pflügers Archiv 430 (1995), S. 181-187 
    Details
    ISSN: 1432-2013
    Keywords: Chronic renal failure ; Subtotal nephrectomy ; Nitric oxide ; Nitric oxide inhibition ; Renal haemodynamics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To assess the renal haemodynamic response to manipulations of the nitric oxide (NO) system, we examined subtotally nephrectomized (SNX) rats and control rats (CON) 28 days after their operation. Bolus infusions of the NO synthase inhibitor N G-nitro-l-arginine (l-NA) were given intravenously at doses of 2 mg/kg and 10 mg/kg. Blood pressure was measured intra-arterially, glomerular filtration rate was measured by inulin clearance and fractional changes in renal blood flow (RBF) were determined by a Doppler flow probe. Both doses of l-NA caused a similar and dose dependent increase in mean blood pressure in both SNX and CON rats. In contrast, the decrease in RBF and the increase in the renovascular resistance index (RVRI) was less in SNX rats as compared to CON rats (RBF = −70.1±2.2% of baseline vs −52.7±5.2%, P〈0.01; RVRI = +177±9% of baseline vs +243±24%, P〈0.05). These changes were not affected by autonomic blockade (hexamethonium), or by blockade of the angiotensin II receptor (Losartan). The exogenous NO donor sodium nitroprusside (0.5 and 1.5 μg · kg−1 · min−1) lowered mean blood pressure to a similar degree in SNX and CON rats; in contrast, RVRI decreased less in SNX rats (86.9±9.2% of baseline) than in CON rats (68.2±4.6%, P〈0.05). We conclude that the reaction of the renal vasculature to manipulations of the NO system is altered in the SNX rats. The data suggest that in the remnant kidney, renovascular resistance is less dependent on endogenous NO and the vascular bed is less sensitive to exogenous NO.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00374648
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  • 8
    Electronic Resource
    Electronic Resource
    The gene encoding endothelial nitric oxide synthase, Nos3, maps to rat Chromosome 4 (1995)
    Springer
    Mammalian genome 6 (1995), S. 758-759 
    Details
    ISSN: 1432-1777
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00354306
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