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  • 1995-1999  (1)
  • 1985-1989  (3)
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  • 1
    Electronic Resource
    Electronic Resource
    Studies on the human metabolism of iproplatin (1989)
    Springer
    Cancer chemotherapy and pharmacology 25 (1989), S. 10-14 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We have previously shown that a significant portion of the total platinum in the plasma of patients receiving iproplatin is protein-bound [17]. We have also identifiedcis-dichloro-bis-isopropylamine platinum(II) (CIP) as a major metabolite of iproplatin [19]. To understand the nature of the bound platinum, we carried out in vitro comparative protein-binding studies for iproplatin and CIP. These studies indicate that when CIP is incubated in plasma, protein binding occurs, with a 2.7-h half-life for the disappearance of CIP; the parent complex does not bind and is stable in plasma for at least 48 h. The time dependence of protein binding with CIP suggests the formation of other chemical species from CIP that may be responsible for the observed protein binding. The results indicate that in patients receiving the drug, the reduction of iproplatin to CIP must take place intracellularly and that CIP or its protein-binding derivatives must efflux from the cells into the plasma. Efflux studies carried out to explore this possibility with cells in the whole blood showed that iproplatin was taken up into cells, but the efflux of protein-binding iproplatin metabolites did not occur. To understand further the nature of the metabolites of iproplatin, we carried out195Pt-NMR (nuclear magnetic resonance) studies with urine from two patients who received a high dose of iproplatin (500 mg/m2). The predominant signals from the195Pt-NMR corresponded to the divalent platinum complexes and not to quadrivalent complexes, indicating that the iproplatin metabolites in urine are divalent in nature.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00694331
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of sleep deprivation on the growth hormone response to the alpha-2 adrenergic receptor agonist, clonidine, in normal subjects (1997)
    Springer
    Journal of neural transmission 104 (1997), S. 291-298 
    Details
    ISSN: 1435-1463
    Keywords: Sleep deprivation ; clonidine ; growth hormone ; adrenergic receptor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary One night's sleep deprivation (SD) increased the growth hormone (GH) response to clonidine (2 ug/kg iv) in 11 normal men (p 〈 0.005). This finding may indicate that SD enhances alpha-2 adrenergic receptor function or that the GH response to GH releasing factor is increased by SD.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01273189
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Aluminium and calcium in soil and food from Guam, Palau and Jamaica: Implications for amyotrophic lateral sclerosis and parkinsonism-dementia syndromes of Guam (1989)
    Springer
    Environmental geochemistry and health 11 (1989), S. 45-53 
    Details
    ISSN: 1573-2983
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Medicine
    Notes: Abstract Low calcium and high aluminium concentrations in the soils, waters and native foods have been hypothesised as environmental factors contributing to the unusually high incidence of amyotrophic lateral sclerosis and parkinsonism with dementia (ALS-PD) found on the island of Guam. The amounts of elemental aluminium and calcium were measured in foods of the native diet of the Chamorro people of Guam. The amount of aluminium eluted from topsoil by water at pH 7 at 22 °C was also measured. For comparison, food, water and soil samples were collected from two islands which have not reported a high incidence of ALS-PD syndromes: Palau and Jamaica. Compared with agricultural soils of Jamaica or Palau, the agricultural soils of Guam averaged 42-fold higher yield of elutable aluminium. The food data, however, do not indicate a differentially high exposure to elemental aluminium or low calcium intake in the diet of any one population. While this study did not detect an unusually high dietary aluminium or low dietary calcium content, the soils and possibly the dusts of Guam may be a major source of aluminium entering the body of the native people, particularly through the respiratory epithelium. Since iipid soluble organic ligands of aluminium more readily penetrate epithelial membranes, further study of soil aluminium ligands is required.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01782992
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Studies of skeletal cadmium assay and toxicity (1988)
    Springer
    Journal of radioanalytical and nuclear chemistry 124 (1988), S. 79-84 
    Details
    ISSN: 1588-2780
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract Flameless Atomic Absorption Spectrophotometry was found to be a sensitive (2·10−12 g detection limit), accurate but destructive method for cadmium assay in bone biopsy samples (about 30 mg dry weight). The inductively coupled plasma emission technique was poorer in sensitivity (1.2·10−9 g) and is also a destructive method. Activation Analysis is still less sensitive (2·10−8 g detection limit) but a nondestructive one. Cadmium was found to accumulate in bone of rats fed, for 5 weeks, 0, 50, and 100 mg Cd/l in drinking water and the bone concentrations were 0.16, 1.09, and 2.6 mg Cd/kg bone (dry wt). Histological examination of the bones showed that cadmium induced increased osteoid surface in the bone with no evidence of accompanying kidney damage. This suggests a primary effect of cadmium on bone rather than secondary effect due to kidney damage.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02035507
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    Paper (German National Licenses)
    Fulltext
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