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  • 1
    Electronic Resource
    Electronic Resource
    Stereochemical analysis of the methyl transfer catalyzed by cobalamin-dependent methionine synthase from Escherichia coli B (1986)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 108 (1986), S. 3152-3153 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja00271a081
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  • 2
    Electronic Resource
    Electronic Resource
    Metallothionein content increased in the liver of mice exposed to magnetic fields (1996)
    Springer
    Archives of toxicology 70 (1996), S. 315-318 
    Details
    ISSN: 1432-0738
    Keywords: Key words Metallothionein ; Static magnetic fields ; Carbon tetrachloride ; Liver ; Mice
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Although recent studies have shown that various stress can induce metallothionein (MT) synthesis in animal tissues, the induction of MT synthesis by exposure to static magnetic fields (SMF) has not been reported. We measured MT levels in the liver, kidney and brain of mice exposed to SMF and also evaluated the effect of SMF exposure on the induction of hepatic MT by treatment with carbon tetrachloride (CCl4). The MT content in the liver was significantly increased by exposure to 4.7 T of SMF for 6, 24, or 48 h, whereas that in the kidney or brain was not changed compared to the control. The combination of CCl4 injection and SMF exposure induced elevation of the hepatic MT content exceeding that induced by either treatment alone. These results indicate that exposure to the strong SMF induces MT synthesis in the liver in mice and enhances the hepatic MT synthesis induced by CCl4 administration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002040050280
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  • 3
    Electronic Resource
    Electronic Resource
    Development of calcitonin gene-related peptide slow-release tablet implanted in CSF space for prevention of cerebral vasospasm after experimental subarachnoid haemorrhage (1996)
    Springer
    Acta neurochirurgica 138 (1996), S. 1230-1240 
    Details
    ISSN: 0942-0940
    Keywords: Calcitonin gene-related peptide ; slow-release tablet ; subarachnoid haemorrhage ; cerebral vasospasm
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The calcitonin gene-related peptide (CGRP), a known potent intrinsic cerebral vasodilator, is contained in the sensory nerves from trigeminal ganglia that inervate the cerebral arteries. We previously reported that human α CGRP (hCGRP) dilates spastic cerebral arteries after experimental subarachnoid haemorrhage (SAH) in rabbits. In the present study, we investigated the prophylactic potential of a sustained higher cerebrospinal fluid level ofhCGRP against experimental cerebral vasospasm. AnhCGRP slow-release tablet (hCGRP s-r tablet) was developed for cisternal implantation. Experimental SAH was induced by percutaneous cisternal injection of autologous arterial blood. Angiography was initiated on day 1 (before SAH) and performed everyday. ThehCGRP s-r tablet was implanted into the cisterna magna on day 2 in the treated groups. The spastic response of the basilar artery was maximized on day 4 in the non-treated (80.7% of day 1) and the placebo-treated (79.3%) groups. In contrast, the arterial diameters on day 4 were 96.1% and 90.5% of day 1 in the groups implanted withhCGRP 24 μg and 153 μg s-r tablets, respectively. We also measured the concentration ofhCGRP in the cerebrospinal fluid (CSF) following implantation of thehCGRP 24 μg s-r tablet in the cisterna magna. The hCGRP concentration before implantation was below the dectable level. Following implantation, thehCGRP level in the CSF was 23.12 nmol/L on the second day and remained at elevated levels until the fifth day. These experiments suggest that the intrathecal single implantation of thehCGRP s-r tablet could produce an elevated concentration ofhCGRP in the CSF over five days and have prevented the cerebral vasospasm after SAH in the rabbit. ThehCGRP s-r tablet may be clinically applicable in the treatment of patients with SAH against cerebral vasospasm.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01809753
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  • 4
    Electronic Resource
    Electronic Resource
    High-pressure Raman study of the hydrogen-bonded crystalline formamide (1988)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 89 (1988), S. 2743-2747 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: The Raman spectra of hydrogen-bonded crystalline HCONH2 and HCOND2 have been measured up to 10 GPa at 300 K in a gasketed diamond anvil cell. The frequencies of the in-plane intermolecular stretching mode which characterizes the hydrogen bond along the zig–zag chain increase with increasing pressure with a slope (dν/dP) of 11.1 cm−1/GPa, and its slope becomes steeper, to 19.2 cm−1/GPa, at about 5.0 GPa (=Pc). The frequencies of the intramolecular ND2 stretching mode decrease with increasing pressure at all pressure range except around Pc where they show an increase of 20 cm−1. It turns out from these results that (1) the hydrogen (deuteron) bonds along the chain direction become stronger in response to the pressure, and their increasing strength are more developed above Pc, and (2) the other type of hydrogen (deuteron) bonds which bridge the chains to make their planar hydrogen-bonded network are weakened around Pc. The pressure-induced phase transition at Pc is discussed by focusing on the behavior of two types of hydrogen bondings and the effect of the interplanar interaction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.455026
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  • 5
    Electronic Resource
    Electronic Resource
    Brillouin scattering of carbon disulfide at pressures up to 70 kbar (1987)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 86 (1987), S. 7189-7193 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: Brillouin scattering was measured at room temperature in liquid and solid CS2 in a diamond anvil cell up to 70 kbar. In the liquid phase, the acoustic velocity and the refractive index were determined as a function of pressure: The former allowed us to determine the equation of state, ρ=0.206 P0.40+1.144 (1 kbar≤P≤13 kbar) with density ρ in g/cm3 and pressure P in kbar, and the latter was well fitted by the Lorentz–Lorenz relation yielding the pressure-insensitive polarizability of 8.20×10−24 cm3. In the solid phase, the pressure dependence of longitudinal- and transverse-acoustic phonon velocities was determined up to the appearance of black CS2 which was formed at pressures above 70 kbar, and the high optical and elastic anisotropy of crystalline CS2 is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.452320
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  • 6
    Electronic Resource
    Electronic Resource
    Two-dimensional toroidal electron analyzer for energy and angular dispersive measurements (1999)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 70 (1999), S. 1970-1977 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: A toroidal electrostatic analyzer with a two-dimensional position-sensitive electron detector has been developed for the measurement of differential excitation cross sections in electron-ion collisions. The electron position is resolved simultaneously in the energy and angular dispersive directions of the analyzer. The present electron analyzer is specially designed with a narrow curved entrance slit and a wide exit slit coupled with an exit lens system after the toroidal deflector, which can give a wide energy dispersed range of 20% of the mean pass energy and a large angular range extending from 30° to 120°. The performance of the spectrometer has been studied by measuring the scattered electrons from Ar atoms and from a highly oriented pyrolytic graphite surface, indicating the usefulness of the present analyzer in electron spectroscopy. A brief description of the method for a spectrum transformation from Cartesian coordinates to polar coordinates is also presented. © 1999 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1149696
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  • 7
    Electronic Resource
    Electronic Resource
    High-pressure Brillouin study of solid HBr at pressures up to 7 GPa (1999)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 111 (1999), S. 10617-10621 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: High-pressure Brillouin scattering measurements have been carried out in orientationally disordered (OD) phases I and I′ of solid HBr, which yielded the first determination of acoustic velocities for all directions, the refractive index, the polarizability, the density, adiabatic elastic constants (C11, C12, and C44), bulk modulus, and the elastic anisotropy as a function of pressure up to 7 GPa and at room temperature. The I→I′ phase transition in solid HBr was confirmed on the discontinuous pressure dependence at P=2.3 GPa for average errors of the least-squares fit by the analysis of in situ Brillouin spectroscopy. These elastic properties of solid HBr are compared with recent results in the OD phase I of solid HCl. We suggest that the form of the potential energy function for intermolecular forces in solid HBr is similar to that in HCl. © 1999 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.480414
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  • 8
    Electronic Resource
    Electronic Resource
    A case of serratiopeptidase-induced subepidermal bullous dermatosis (1999)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 141 (1999), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.1999.03225.x
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  • 9
    Electronic Resource
    Electronic Resource
    Non-lethal junctional epidermolysis bullosa in a dog (1997)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 137 (1997), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We report a 4-year-old female mongrel dog with a history since birth of erosions and atrophic skin, with pigmentation and alopecia on the face, trunk and extremities, together with dystrophic nails. Light microscopy revealed subepidermal blisters with minimal inflammation and electron microscopy confirmed that the ultrastructural site of separation site was at the lamina lucida. Indirect immunofluorescence of the dog's skin detected the positive expression of laminin 5. BPAG2, integrinα6 and type VII collagen. These clinical, ultrastructural and immunohistochemical features suggested that the dog had a non-lethal subtype of junctional epidermolysis bullosa (JEB). This is the first confirmed case of non-lethal JEB in a dog and presents a possible candidate for an animal model of gene therapy. Further study should provide important information of the phenotype, pathophysiology and prognosis of non-lethal JEB in humans.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.1997.18671936.x
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  • 10
    Electronic Resource
    Electronic Resource
    A new composite-cavity laser with two different waveguide cores for stable longitudinal mode operation (1989)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 66 (1989), S. 5726-5730 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We have developed a new composite-cavity laser with two different waveguide cores connected near the front mirror in the same cladding. This composite cavity has a built-in structure that is capable of giving high mode selectivity because of strongly modulated reflectivity of the front mirror. The laser shows very stable single longitudinal mode operation in a temperature range as wide as about 50 °C for output powers from 3 to 100 mW without mode hopping.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.343640
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