Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Two sulfur-containing ansamycin antibiotics fromStreptomyces albolongus (1986)
    Springer
    Cellular and molecular life sciences 42 (1986), S. 1167-1170 
    Details
    ISSN: 1420-9071
    Keywords: Ansamycin ; ansathiazin ; awamycin ; Streptomyces albolongus C-46366 ; gram-positive bacteria
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Two sulfur-containing ansamycin antibiotics were isolated from the culture broth ofStreptomyces albolongus C-46366; the major one was identical with awamycin and the minor one was a new ansamycin antibiotic, ansathiazin. Their structures were elucidated from their reactions and spectroscopic analyses. These antibiotics were active against gram-positive bacteria, acid-fast bacteria and a protozoan.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01941296
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Effect of HTLV-III on the macromolecular synthesis in HTLV-I carrying cell line, MT-4 (1986)
    Springer
    Medical microbiology and immunology 175 (1986), S. 325-334 
    Details
    ISSN: 1432-1831
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Upon infection of human T-cell leukemia virus type I (HTLV-I)-carrying human T-cell lines such as MT-4, HTLV-III, a probable etiologic agent of acquired immune deficiency syndrome (AIDS) caused fast and strong cytopathic effects leading ultimately to the death of the cells. Such effects were preceded by the rapid induction of HTLV-III antigens. Cell lines not infected with HTLV-I could, however, be subcultured after infection with HTLV-III, although they were also positive for HTLV-III antigens. To understand this cytopathogenicity of HTLV-III in HTLV-I bearing cells, macromolecular synthesis, including DNA synthesis and total protein synthesis, and also IL-2 receptor expression were investigated kinetically. In infected MT-4 cells DNA synthesis was markedly inhibited by HTLV-III after the HTLV-III antigen synthesis became evident. This inhibition occurred before cell damage was detected in terms of viable cell-growth, but after induction of HTLV-III antigen. Puromycin, at 40 Μg/ml, caused no toxic changes in MT-4 cells over 3 days but prevented viral antigen synthesis and virus-induced cytopathic effect. Protein synthesis and IL-2 receptor expression were also inhibited at 4 and 5 days post infection. The degree of the effects and their kinetics suggest that they are the secondary effects of cytotoxicity by HTLV-III infection.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02123869
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Effect of retinoic acid on the replication of human immunodeficiency virus in HTLV-I-positive MT-4 cells (1987)
    Springer
    Medical microbiology and immunology 176 (1987), S. 189-198 
    Details
    ISSN: 1432-1831
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The inhibitory effect of all-trans-retinoic acid (RA) on human immunodeficiency virus (HIV) replication upon infection was studied quantitatively using a novel bioassay system with a HTLV-I-carrying human T-cell line, MT-4. The results can be summarized as follows. (1) The appearance of HIV antigen was significantly reduced when the cells were treated with more than 1 μg/ml of the chemical after infection. When HIV specific plaque assay was performed to titrate the virus from the supernatant of culture treated with 10 μg/ml of RA no plaques were observed. (2) When RA was applied directly in the plaque assay, significant decrease of the number of plaques was discerned showing 68, 66, 47 and 16, at doses of 0.1, 1, 5, and 10 μg/ml of RA, while 102 plaques were formed in the control dish. (3) The appearance of cytopathic effects of MT-4 cells by HIV was more delayed in RA-treated cultures than in untreated cultures. (4) Concomitant treatment of the cells with 5 μg/ml of RA and various concentrations of suramin resulted in the more effective inhibition of HIV replication than suramin alone. (5) RA did not inhibit the reverse transcriptase activity (RT) of HIV directly. These data suggest that RA inhibits HIV replication by inducing an antiviral state in the cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00196686
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Comparison of atrophic and goitrous auto-immune thyroiditis in children: Clinical, laboratory and TSH-receptor antibody studies (1990)
    Springer
    European journal of pediatrics 149 (1990), S. 529-533 
    Details
    ISSN: 1432-1076
    Keywords: Atrophic auto-immune thyroiditis ; Goitrous auto-immune thyroiditis ; TSH-binding inhibitor immunoglobulins ; Thyroid stimulation blocking antibodies ; TSH receptor antibodies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We studied the clinical features, laboratory and thyroid functions and thyrotropin (TSH)-receptor and thyroid-stimulation antibodies in 21 patients with atrophic auto-immune thyroiditis (AAT) and 48 patients with goitrous auto-immune thyroiditis (GAT) of childhood onset. The clinical features of patient with AAT were cessation of growth and obesity, while asymptomatic enlargement of the thyroid gland was the sole symptom in most patients with GAT. Although the ages at diagnosis were comparable in both groups, the estimated ages at onset were much lower in patients with AAT than in those with GAT. Patients with AAT exhibited more severe hypothyroidism when evaluated by serum thyroxine (T4), tri-iodothyronine (T3), TSH, cholesterol levels and basal metabolic rates. The 24h123I-thyroidal uptake was significantly lower in patients with AAT than in those with GAT. None of the 19 patients with AAT possessed TSH-binding inhibitor immunoglobulins (TBII). On the other hand, 3 of the 32 GAT patients tested, possessed weak to potent TBII activities. Three TBII-positive patients with GAT also possessed thyroid-stimulation blocking antibodies. These findings suggest that: 1. Pathogenesis of AAT in children whose onset of hypothyroidism was before puberty is not due to TSH-receptor blocking antibodies, which are often found in patients with AAT of postpubertal onset. 2. AAT in children is considered not to be due to the later stage of GAT. 3. Some patients with GAT possessed TSH-receptor blocking antibodies. The aetiology and pathogenesis of AAT in children have yet to be elucidated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01957685
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Refined crystal structure of pseudoazurin from Methylobacterium extorquens AM1 at 1.5 Å resolution (1994)
    Copenhagen : International Union of Crystallography (IUCr)
    Acta crystallographica 50 (1994), S. 317-328 
    Details
    ISSN: 1399-0047
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: The crystal structure of pseudoazurin from Methylobacterium extorquens AM1 (PAZAM1) has been solved by the molecular replacement method using copper–copper distances as translation parameters, which were obtained from difference Patterson maps calculated with the synchrotron radiation data containing the multiwavelength anomalous-dispersion effect. The structure refinement was carried out by the use of molecular dynamics optimization and the restrained least-squares method. The final crystallographic R factor was 19.9% for the 14 365 reflections greater than 3σ between 1.5 and 8.0 Å resolution. This report describes the characteristic features of the structure of PAZAM 1 as well as the effectiveness of synchrotron radiation for structure analysis of metalloproteins. The environment of the metal active site and the structural differences among blue-copper proteins are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0907444994000260
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Mutations in the unc-41 Gene Cause Elevation of Acetylcholine Levels (1994)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 63 (1994), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Mutations in the Caenorhabditis elegans unc-41 gene result in an allele-dependent elevation of acetylcholine content. Eight recessive alleles (cn252, e268, e399, e650, e1175, e1199, e1294, and e870) lead to phenotypes including uncoordinated locomotion, slow growth, a small mature body, and resistance to the acetylcholinesterase inhibitors as well as the elevation of acetylcholine content. The remaining two alleles, e554 and e1162, exhibit normal acetylcholine levels but display the short-body phenotype in a semidominant way. To determine the localization of the elevated acetylcholine content, a method for the isolation of synaptic vesicles from C. elegans was established. The elevation of acetylcholine content in the unc-41 mutants is accompanied by the accumulation of synaptic vesicles. We propose that at least one function of the unc-41 gene relates to the release of neurotransmitters.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.1994.63020439.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    Construction of compact electron storage ring JSR : International conference on synchrotron radiation instrumentation (1989)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 60 (1989), S. 1724-1727 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: A compact electron storage ring (JSR) is under construction in order to study accelerator technologies and to be used as the test ring aiming at a highly brilliant synchrotron radiation facility (6–8 GeV). The JSR lattice is a double-focusing achromatic type. The circumference is 20.5 m. However, even in this small ring, one straight section with a length of ∼1.5 m, where the dispersion is free, is provided for the insertion device study. The electron beam is supplied by the linac with an energy of 150 MeV, and the stored energy is slowly increased up to 300 MeV. Power supplies of all magnets and the rf system are controlled by a real-time computer through optical fiber links, and signals of beam monitors are stored in the same computer so that it is easy to test any type of control procedures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1140939
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    Neural and Behavioral Responses to Amino Acids in Mice and Rats (1987)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 510 (1987), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1987.tb43551.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 9
    Electronic Resource
    Electronic Resource
    Crystal structure analysis of cytochrome c' by the multiwavelength anomalous diffraction method using synchrotron radiation (1986)
    Copenhagen : International Union of Crystallography (IUCr)
    Applied crystallography online 19 (1986), S. 448-452 
    Details
    ISSN: 1600-5767
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Geosciences , Physics
    Notes: A multiwavelength X-ray diffraction study was performed at 6 Å resolution on the native cytochrome c′ crystal from Rhodospirillum rubrum, which contains heme irons. The X-ray intensity data from the crystal were collected on a four-circle diffractometer with three wavelengths, λ1 = 1.077, λ2 = 1.730 and λ3 = 1.757 Å, using the synchrotron radiation produced by the storage ring in the Photon Factory, National Laboratory for High Energy Physics. λ2 and λ3 are above and below the energy of the K absorption edge of iron (λe = 1.743 Å) respectively, while λ1 is far from the edge. The positions of the two iron atoms in the crystal could be determined from the difference Patterson maps based on either the real or imaginary components of the anomalous scattering effect caused by iron. The best phase angles for the crystal were calculated from the X-ray intensity data measured with λ1 and λ2 by the method which is basically the same as the isomorphous replacement method. Although the resulting best phase angles differed 75° on the average from those obtained by the multiple isomorphous replacement method, the molecular boundary and α helices could be recognized on the electron density map.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0021889886088970
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 10
    Electronic Resource
    Electronic Resource
    Binding of a non- β -lactam antibiotic to penicillin-binding proteins (1987)
    [s.l.] : Nature Publishing Group
    Nature 325 (1987), S. 179-180 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Lactivicin was produced by two strains of bacteria, YK-258 and YK-422, isolated from soil samples collected in Japan. It exists in aqueous solutions as an approximately 1:1 equilibrium mixture of two epimers (Fig. 1). The chemical properties and structural elucidation of lactivicin will be ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/325179a0
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...