Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Effect of cholera toxin on the induction of gamma-glutamyl transpeptidase-positive clones by benzo(a)pyrene in embryonic mouse tongue cells in culture (1986)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral pathology & medicine 15 (1986), S. 0 
    Details
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract The utility of gamma-glutamyl transpeptidase (GOT) as a histochemical marker to study the carcinogen-induced changes and its possible modulation by cholera toxin was explored in primary cell cultures. It was observed that cholera toxin not only promotes growth of fibroblasts in primary cell culture, but it also enhances the GGT-positive foci induced by benzo(a)pyrene. It is interesting to speculate that cholera toxin may be acting as a tumor promoter in primary cell cultures of embryonic mouse tongue.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0714.1986.tb00607.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Catechin as an antimutagen: its mode of action (1988)
    Springer
    Journal of cancer research and clinical oncology 114 (1988), S. 177-182 
    Details
    ISSN: 1432-1335
    Keywords: Catechin ; Acacta catechu ; Cyanidoanol-3 ; Betel quid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In the present study, we report that the betel quid ingredient catechu, its extract and pure principle catechin were nonmutagenic in Salmonella typhimurium TA 100, TA 1535, TA 98, and TA 1538 assays with or without metabolic activation. They also exhibited dose-dependent decreases in mutagenicity of benzo(a)pyrene [B(a)P] and dimethylbenz(a)anthracene (DMBA) in strain TA 98 with metabolic activation. We further report that these compound inhibited activites of cytochrome P-450 and had no effect on glutathione S-transferase but increased the glutathione content in rat liver tissue. Simultaneous treatment of catechin prevented the mutagenic activity of B(a)P and DMBA metabolites in strain TA 98 in the absence of metabolic activation. Pre-and posttreatment of bacteria with catechin had no effect on the mutagenicity of B(a)P and DMBA metabolites. Catechin also inhibited the in vitro binding of 3H-B(a)P metabolites to calf thymus DNA. Catechu extract and catechin inhibited the nitrosation of methylurea by nitrite at pH 3.6 and 30°C. The formation of nitrosomethylurea in the reaction mixture was monitored by measuring the histidine revertants of strain TA 1535 in the absence of metabolic activation. Pre-and post-treatment of catechu extract or catechin had no effect on the mutagenicity of nitrosomethylurea in TA 1535. The nitrosation inhibition by catechin was through scavenging of nitrite observed at pH 3.6. The above study indicates that catechu in betel quid may act as an antimutagen and may suppress the mutagenic potential of other betel quid mutagens.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00417833
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Carcinogenicity of Indian bidi and cigarette smoke condensate in Swiss albino mice (1988)
    Springer
    Journal of cancer research and clinical oncology 114 (1988), S. 647-649 
    Details
    ISSN: 1432-1335
    Keywords: Indian bidi and cigarette smoke condensate ; Polycyclic aromatic hydrocarbon ; Careinogenicity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The carcinogenicity of Indian bidi and cigarette smoke condensate given by gavage was studied in Swiss mice. Bidi smoke condensate induced liver haemangiomas in four animals, forestomach papilloma in one animal and carinomas in two animals, in one of them was in the oesophagus and in the other in the forestomach. At the same dose level cigarette smoke condensate failed to produce any tumour. Similarly, none of the untreated and solvent-treated control mice developed tumour. Chemical analysis of the smoke concensate of bidis and cigarettes showed that condensate from bidis had a higher benzo[a]pyrene level than was observed in cigarette smoke condensate, when compared on the basis of the mass (mg) burnt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00398193
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Carcinogenicity, perinatal carcinogenicity and teratogenicity of low dose metronidazole (MNZ) in Swiss mice (1986)
    Springer
    Journal of cancer research and clinical oncology 112 (1986), S. 135-140 
    Details
    ISSN: 1432-1335
    Keywords: Metronidazole ; Carcinogenicity ; Teratogenicity ; Perinatal carcinogenicity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Metronidazole (MNZ), a widely used therapeutic drug, was administered to male and female Swiss mice intragastrically at a dose of 2 mg MNZ/mouse per day, 5 days a week, every alternate week, throughout their life span to test its carcinogenicity. The treatment induced a significant increase in the overall incidence of tumors in female mice but not in male mice. At the same dose, no teratogenic effect was observed. Perinatal carcinogenicity was studied by following up animals till the end of the F2 generation. Though different groups of animals were considered, a significant increase in tumor incidence was observed only in F1 mice which received MNZ treatment during gestation as compared to the corresponding control mice which received distilled water. The F1 mice which received MNZ during gestation, lactation, and subsequently in adulthood, and the F2 progeny had a tumor incidence comparable to that observed in control mice.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00404396
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Effects of tobacco-specific nitrosamines and snuff extract on cell proliferation and activities of ornithine decarboxylase and aryl hydrocarbon hydroxylase in mouse tongue primary epithelial cell cultures (1989)
    Springer
    Journal of cancer research and clinical oncology 115 (1989), S. 558-563 
    Details
    ISSN: 1432-1335
    Keywords: Tobacco-specific nitrosamines ; Snuff ; Ornithine decarboxylase ; Aryl hydrocarbon hydroxylase ; Oral carcinogenesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Tobacco and its related compounds, including snuff, have been implicated in oral cancers. Tobacco-specific nitrosamines have been shown to be the causative agents present in tobacco and its related compounds. Both, N-nitrosonornicotine (NNN) and its butanone derivative (NNK) are carcinogenic in animals. In our in vitro studies using embryonic mouse tongue epithelial cells, NNN is linked to an increase in [3H]dT uptake along with a concomitant increase in ornithine decarboxylase and aryl hydrocarbon hydroxylase activities. NNK, the more potent compared to NNN, causes a further increase in [3H]dT uptake, cell count and ornithine decarboxylase activity. However, aryl hydrocarbon hydroxylase behaves differently in cultures treated with NNK compared to those treated with NNN. Snuff extract has an overall inhibitory effect on cell count, [3H]dT uptake, and ornithine decarboxylase and aryl hydrocarbon hydroxylase activities when administered either alone or in combination with NNN and NNK. How the inhibitory effect of snuff in the presence of tobacco-specific nitrosamines is involved in oral carcinogenesis should be further investigated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00391358
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Experimental studies on mutagenic and carcinogenic effects of tobacco chewing (1985)
    Springer
    Journal of cancer research and clinical oncology 109 (1985), S. 203-207 
    Details
    ISSN: 1432-1335
    Keywords: Chewing tobacco ; Nitrosamine ; Oral cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The alcoholic extract of the chewing (Pandharpuri) variety of tobacco (Nicotiana tabaccum) was subjected to mutagenicity and tumorigenicity studies. The extract was found to be mutagenic in strain TA 98 of Salmonella typhimurium in the presence of S 9 mixture. It also induced 8 AZG-resistant mutation in V 79 Chinese hamster cells. Administration of tobacco extract to male Swiss mice by gavage or mixed with diet resulted in an increased incidence of lung/liver tumors. Further, an additive effect of tobacco extract and hexachlorocyclohexane on liver tumor induction was observed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00390358
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...