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  • 1
    Electronic Resource
    Electronic Resource
    Buchbesprechungen (1986)
    Springer
    Journal of molecular medicine 64 (1986), S. 799-799 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01732190
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Asymptotic error expansion and Richardson extranpolation for linear finite elements (1986)
    Springer
    Numerische Mathematik 49 (1986), S. 11-37 
    Details
    ISSN: 0945-3245
    Keywords: AMS(MOS):65N300 ; 65B05 ; CR: G1.8
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Summary The elliptic Ritz projection with linear finite elements is shown to admit asymptotic error expansions on certain uniform meshes. This justifies the application of Richardson extrapolation for increasing the accuracy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01389427
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  • 3
    Electronic Resource
    Electronic Resource
    Extrapolation techniques for reducing the pollution effect or reentrant corners in the finite element method (1987)
    Springer
    Numerische Mathematik 52 (1987), S. 539-564 
    Details
    ISSN: 0945-3245
    Keywords: AMS(OMS): 65N30, 65B05, 73K25 ; CR: G1.8
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Summary Standard finite element schemes applied to boundary value problems on domains with reentrant corners suffer from a global loss of accuracy caused by the influence of the corner singularities. For a model situation, it is shown that this pollution effect can be completely described in terms of an asymptotic error expansion with respect to fractional powers of the mesh size parameter. This provides the basis of an extrapolation procedure which recovers the full order of accuracy for the solution as well as for the corresponding stress intensity factors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01400891
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Synthesis, antitumor activity, distribution and toxicity of 4-[4-[Bis(2-chloroethyl)amino]phenyl]-1-hydroxybutane-1 1-bisphosphonic acid (BAD), a new lost derivative with increased accumulation in rat osteosarcoma (1986)
    Springer
    Journal of cancer research and clinical oncology 111 (1986), S. 209-219 
    Details
    ISSN: 1432-1335
    Keywords: Bisphosphonate-linked cytostatic N-Lost derivative ; Bone-seeking agent ; Bone tumor ; Osteosarcoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The aim of this study was to investigate whether the newly synthesized bisphosphonic acidlinked N-Lost derivative BAD retains bone-seeking and cytostatic properties. The paper describes experiments on mutagenicity in vitro and on toxicity in vivo. BAD is characterized by very low mutagenic activity toward histidine auxotrophic Salmonella typhimurium strains. Cytotoxic effects were tested in rat osteosarcoma and in Walker carcinosarcoma 256B. The LD50 of i.v. injected BAD was 146 mg/kg. Acute toxicity is probably caused by calcium complexing of the bisphosphonate part of the molecule. Labeling experiments showed moderate accumulation in bone and osteosarcoma, as well as in lung metastases. BAD effected high tumor growth inhibition in osteosarcoma and Walker carcinosarcoma-bearing rats and marked prolongation of survival; histologic and radiographic examination revealed rapid calcification of osteosarcoma and lung metastases. BAD-pretreatment produced protective effects against osteolysis induced by intratibially implanted Walker carcinosarcoma ascites cells. The cytostatic efficacy of equitoxic doses of BAD in rat osteosarcoma is comparable to that of dacarbazine and in Walker carcinosarcoma to that of melphalan.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00389236
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  • 5
    Electronic Resource
    Electronic Resource
    Hepatocellular carcinoma and hepatitis B virus infection: molecular evidence for monoclonal origin and expansion of malignantly transformed hepatocytes (1987)
    Springer
    Journal of cancer research and clinical oncology 113 (1987), S. 466-472 
    Details
    ISSN: 1432-1335
    Keywords: Hepatitis B virus ; Hepatocellular carcinoma ; Hepatocarcinogenesis ; viral oncogenesis ; Molecular hybridization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The clonality of tumor cells was studied in a patient with metastasizing hepatocellular carcinoma (HCC). Using hepatitis B virus (HBV) DNA as a genetic marker, the pattern of integration of viral DNA into the tumor cell genome was determined by Southern blot analyses of DNAs extracted from different HCC lesions in the liver and both lungs. All tumor tissues examined were found to have viral DNA integrated into the same site(s) of the cellular genome. This finding provides direct molecular evidence for a monoclonal origin and expansion of malignantly transformed hepatocytes during tumor growth and metastasis. This characteristic is similar to other human cancers associated with viral infections, such as adult T-cell leukemia, Burkitt's lymphoma, or cervical cancer, and is important für our understanding of viral oncogenesis in man.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00390041
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  • 6
    Electronic Resource
    Electronic Resource
    257. Entscheidungshilfen bei der Indikation zur Operation der akuten Pankreatitis (1986)
    Springer
    Langenbeck's archives of surgery 369 (1986), S. 784-784 
    Details
    ISSN: 1435-2451
    Keywords: Acute pancreatitis ; Indications for operation ; Decision making ; Akute Pankreatitis ; Operationsindikation ; Entscheidungshilfen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In einer prospektiven Studie an 50 Patienten mit akuter Pankreatitis wurden diagnostische Daten mit der Frage analysiert, ob Indikation und Zeitpunkt zum chirurgischen Vorgehen dadurch beeinflußt werden. Das initiale Labor und der initiale klinische Befund ermöglichen nicht, zwischen operierten und nicht operierten Patienten zu unterscheiden. Die Operationsindikation ist am besten durch wiederholte klinische Untersuchungen zu erkennen. Die initiale ERCP identifiziert mit hoher Sicherheit die biliäre Pankreatitis und leitet beim Gallengangstein direkt zur Therapie über.
    Notes: Summary A prospective clinical study of 50 patients with acute pancreatitis was undertaken to estimate the significance of diagnostic data for assessment of the indication for and the timing of surgical intervention. Initial clinical and laboratory data did not facilitate the choice between conservative and operative treatment. Daily clinical assessment was the most helpful way to determine the indications for and the urgency of surgery. With the aid of the initial endoscopic retrograde cholangiopancreatogram, biliary pancreatitis could be accurately diagnosed and in cases of cholelithiasis, early surgery or endoscopic papillotomy could be performed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01274576
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    Paper (German National Licenses)
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