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  • 1
    Electronic Resource
    Electronic Resource
    Stability study and quantitative determination of mebeverine hydrochloride in tablets by means of reversed-phase high-performance liquid chromatography (1985)
    Springer
    Chromatographia 20 (1985), S. 185-192 
    Details
    ISSN: 1612-1112
    Keywords: Reversed-phase HPLC ; Quantification ; Mebeverine hydrochloride ; Stability ; Mass spectrometry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary A rapid and specific reversed-phase high-performance liquid chromatographic method (RPHPLC) is described for the determination of mebeverine hydrochloride in tablets. Elution was performed on an octyl silane column with a methanol-water mixture (75-25), containing 0.05% hexylamine as silanol-blocking agent, adjusted to pH 5.0 with phosphoric acid. The method gave accurate, precise and reproducible results. The mean recovery of the drug from six synthetic tablet mixtures was 100.0% with a relative standard deviation (RSD) of 0.94%. In order to test the specificity of the method, the interference of the degradation compounds of mebeverine hydrochloride and of the intermediates from the synthesis was investigated. None of them did interfere. By means of mass spectrometry and UV-spectrophotometry, the degradation compounds of mebeverine were identified as veratric acid and as 4-|ethyl-[2-(4-methoxyphenyl)-1-methylethyl]amino| 1-butanol. The stability study proved that mebeverine hydrochloride is very stable in tablets; the tablets still contain more than 95% of the declared drug potency after storage for more than one year at 50°C.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02262709
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Simultaneous quantitative determination of amiloride hydrochloride and hydrochlorothiazide in tablets by high-performance liquid chromatography (1985)
    Springer
    Chromatographia 20 (1985), S. 477-481 
    Details
    ISSN: 1612-1112
    Keywords: Column liquid chromatography ; Amiloride hydrochloride ; Hydrochlorothiazide ; Quantitative determination
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary A procedure for the simultaneous quantitative determination of amiloride hydrochloride and hydrochlorothiazide by high-performance liquid chromatography is proposed. A reversed-phase LiChrosorb C8 stationary phase is used. The eluent consisted of an acetonitrile/0.1M phosphate buffer pH3 (15∶85) mixture, containing 50mM propylamine hydrochloride. In this system amiloride hydrochloride, a basic drug, eluted with a acceptable asymmetry factor (Asf=2.1). A simple extraction procedure with methanol is used. Relative standard deviations of 0.87% and 1.6% were obtained for amiloride hydrochloride and hydrochlorothiazide respectively. Chlorothiazide, a thiazide diuretic, is a suitable internal standard. Furthermore the method is also specific for other thiazide diuretics, potassium-sparing diuretics and loop diuretics and for the respective hydrolysis productes of both drugs. Analysis time is reduced to a minimum; the chromatographic separation is complete within 6 minutes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02344789
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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