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  • 1
    Electronic Resource
    Electronic Resource
    Wachstumsfaktoren (1985)
    Springer
    Journal of molecular medicine 63 (1985), S. 740-746 
    Details
    ISSN: 1432-1440
    Keywords: Growth factors ; Oncogens ; Clinical application ; Clinical trials
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The current understanding in biology and function of 4 growth factors is reviewed. PDGF suggests functions for proto-oncogens in normal cells, which may interact in tightly linked hierachies to induce malignant growth. PDGF-requirement of normal fibroblast cell-lines is lost when the cells are infected with tumor viruses. TGF is able to stimulate growth of normally anchorage dependent cells in an anchorage independent manner in soft agar. This ability is thought to be the best in-vitro correlate of neoplastic transformation. The peptide hormones bombesin/gastrin releasing factor and EGF can act as autocrine growth factors in various lung cancer cell-lines and stimulate clonal tumor cell growth in-vitro. The potential clinical application of these types of growth factors may enable the in-vitro growth from any lung cancer patient and allow individual drug testing. TCGF produced by T-cells to activate T-cells, is central to immune stimulation and immune response. Models for potential indirect anticancer effects either by in-vivo administration or by in-vivo incubation plus passive transfer of T-cells are presented to be initiated in future clinical trials.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01733825
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Lymphangiomyomatosis: A report of three cases treated with tamoxifen (1987)
    Springer
    Journal of molecular medicine 65 (1987), S. 391-393 
    Details
    ISSN: 1432-1440
    Keywords: Lymphangiomyomatosis ; Tamoxifen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Three cases are reported of lymphangiomyomatosis with pulmonary and abdominal manifestations. Two had a chylous pleura effusion, while the third presented a retroperitoneal manifestation, which was completely resectable. Antiestrogen therapy with tamoxifen was administered in all three cases. Two patients died of pulmonary progression after 4 months of therapy. The third is still alive, with stable disease for more than 6 years, and has been receiving tamoxifen for 66 months. These observations indicate that antiestrogen treatment may be as effective as oophorectomy when started at an early stage of the disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01745582
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Buchbesprechungen (1987)
    Springer
    Journal of molecular medicine 65 (1987), S. 368-368 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01745574
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Postremissions-Behandlung der akuten Leukämie im Erwachsenenalter: allogene Knochenmarktransplantation oder Chemotherapie? (1988)
    Springer
    Journal of molecular medicine 66 (1988), S. 614-623 
    Details
    ISSN: 1432-1440
    Keywords: Acute myeloid leukemia ; Acute lymphoblastic leukemia ; Postremission-therapy ; Bone marrow transplantation ; Intensified chemotherapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The impact of bone marrow transplantation and chemotherapy on remission duration and survival in acute leukemia is controversial. Most studies on either procedure deal with selected patients and lack randomized or concurrent controls; many exclude high-risk subgroups. There are only a few preliminary reports on the direct comparison between bone marrow transplantation and intensive chemotherapy. Considerable controversy remains as to whether patients with AML in first remission who have an HLA identical sibling should receive a bone marrow transplant at that time or whether the transplant should be delayed until relapse or second remission. In patients under the age of 25 years, results of bone marrow transplantation are considered to be equivalent or superior to those achieved with chemotherapy. Because of a high lethality rate few results suggest that survival of patients transplanted during first remission is not superior to that obtained by intensified chemotherapy; however, the relapse incidence is decreased. In recent years, results in adult ALL, treated with various intensified programs, have improved considerably and are nearly comparable to those obtained in childhood ALL. Therefore, allogeneic bone marrow transplantation is usually performed in standard risk patients during second remission and, if relapse occurs within the first three years. It is not clear at present whether ALL highrisk patients will benefit from bone marrow transplantation during first remission.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01728802
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  • 5
    Electronic Resource
    Electronic Resource
    Rezidiv eines Wilms' Tumors nach 9jährigem krankheitsfreien Intervall (1988)
    Springer
    Journal of molecular medicine 66 (1988), S. 412-414 
    Details
    ISSN: 1432-1440
    Keywords: Nephroblastoma ; Late recurrence ; Combined treatment modalities
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We report the case of a 25-year old female patient, who presented with intrapulmonary metastases of a Wilms' tumor nine and a half year after initial therapy of a stage I tumor with surgery, local radiation and combined chemotherapy. In general, relapses of Wilms' tumor occur within two year after nephrectomy. Reccurences after more than 7 years are very rare. A relapse of a Wilms' tumor in an adult patient after more than 9 years is not yet published. We treated our patient according to the therapeutic procedure, which is recommended by the National Wilms' Tumor Study as curative treatment of relapses in childhood: complete resection of pulmonary metastases, irradiation of the whole lunge and repeatingly combined chemotherapy with actinomycin D and vincristin. The patient is doing well without evidence of tumor 13 months after thoractomy. A short review of the literature is given.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01737946
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  • 6
    Electronic Resource
    Electronic Resource
    Spontaneous remission of acute myeloid leukemia (1986)
    Springer
    Annals of hematology 52 (1986), S. 165-168 
    Details
    ISSN: 1432-0584
    Keywords: Spontaneous remission ; Acute leukemia ; Prognostic factors ; Regulation of granulopoiesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A patient with acute myelomonocytic leukemia who experienced a spontaneous remission, is reported. He had precedent and concurrent bacterial infections as most of these cases described. Low peripheral WBC and myeloblasts, Auer-rod positive blasts, bone marrow eosinophilia with atypical eosinophils, and a partial deletion of chromosome 16 were favorable prognostic parameters. A brief review of the literature and possible explanations for the regulation of granulopoiesis are presented.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00320532
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    Paper (German National Licenses)
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