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  • 1985-1989  (3)
Source
Material
Years
Year
  • 1
    Electronic Resource
    Electronic Resource
    Urinary dopamine metabolites as indicators of the responsiveness to fenfluramine treatment in children with autistic behavior (1989)
    Springer
    Journal of autism and developmental disorders 19 (1989), S. 241-254 
    Details
    ISSN: 1573-3432
    Source: Springer Online Journal Archives 1860-2000
    Topics: Psychology
    Notes: Abstract Modifications in serotonin and dopamine metabolism were evaluated in 13 children with autistic behavior and related to their responsiveness to fenfluramine treatment. A double-blind medication-placebo crossover design was used. Each patient received 1.5 mg/kg fenfluramine daily for 3 months followed and preceded by placebo for 1 month. Clinical improvement was observed in 6 children (responders). It included reduction of behavioral symptoms such as motor activity, anxiety, mood disturbances, and distractibility. Modifications of serotonin (5-HT), dopamine (DA), and DA metabolites [homovanillic acid (HVA) and dihydroxyphenylacetic acid (DOPAC)] were assessed at urinary levels. Responders and nonresponders showed a significant decrease of urinary 5-HT levels on fenfluramine. The main differences between the two groups of subjects were found with HVA, the major metabolite of DA. Fenfluramine significantly increased HVA levels in responders whereas no significant modification was found in nonresponders. Moreover the initial level of HVA (lower in responders) significantly differentiated the two groups. These results suggest that the clinical response to fenfluramine could be related to the dopaminergic action of this drug and that urinary DA metabolite levels could be considered as indicators of the responsiveness to fenfluramine treatment in children with autistic behavior.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02211844
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Urinary free and conjugated catecholamines and metabolites in autistic children (1988)
    Springer
    Journal of autism and developmental disorders 18 (1988), S. 583-591 
    Details
    ISSN: 1573-3432
    Source: Springer Online Journal Archives 1860-2000
    Topics: Psychology
    Notes: Abstract Urinary catecholamines (DA, NE, E) and their main metabolites (HVA, DOPAC, MHPG) were analyzed both as free and conjugates in eight children diagnosed as autistic according to DSM-III criteria and eight normal children. Significant differences appeared for the urinary excretion of both DA and NE and their respective metabolites: Autistic children showed low DA, high HVA, high NE, low MHPG urinary levels. These results are consistent with previous findings on altered catecholamine metabolism in autistic children. They suggest that autistic behaviour might be related to an abnormal functional imbalance among monoamines either at a molecular level or at a system level. Furthermore, they emphasize the special interest of urinary assays in pediatric research.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02211876
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Dopamine-beta-hydroxylase (DBH) and homovanillic acid (HVA) in autistic children (1986)
    Springer
    Journal of autism and developmental disorders 16 (1986), S. 23-29 
    Details
    ISSN: 1573-3432
    Source: Springer Online Journal Archives 1860-2000
    Topics: Psychology
    Notes: Abstract In the present study, plasma DBH activity and urinary HVA levels were measured in 19 autistic and 15 normal children. DBH activity was significantly elevated in the 8 less retarded autistic patients. In this subgroup, a negative correlation was found between plasma DBH and urinary HVA levels. These results support the hypothesis of a possible involvement of brain catecholamine dysfunction in the production of autistic symptoms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01531575
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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