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  • 1
    Electronic Resource
    Electronic Resource
    Astrocytic pathology of methionine sulfoximine-induced encephalopathy (1989)
    Springer
    Acta neuropathologica 77 (1989), S. 357-368 
    Details
    ISSN: 1432-0533
    Keywords: Hepatic encephalopathy ; Glutamine synthetase ; Methionine sulfoximine ; Oligodendrocyte ; Astrocyte
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To investigate the roles imposed on astrocytes for glutamate metabolism, a specific inhibitor of glutamine synthetase (GS), methionine sulfoximine (MSO), was repeatedly administered to rats and histopathological changes were correlated with glycogen accumulation and the immunocytochemistry of GS and glial fibrillary acidic protein (GFAP). Prolonged MSO-loading (every 12 h up to three times, 100–150 mg/kg body weight) brought about the appearance of astrocytes with swollen, watery nuclei reminiscent of Alzheimer II glia chiefly in the neocortex, hippocampus and lateral thalamus after 24 h. Concomitantly, profound accumulation of glycogen ensued in the superficial three layers of the neocortex, hippocampus and pyriform cortex. GS immunoreactivity appeared enhanced in the cortex, hippocampus and lateral thalamus with parallel increase in GFAP immunoreactivity after prolonged treatment. Oligodendrocytes in the diencephalon and brain stem also normally contained GS immunoreactivity. Some animals developed necrotic lesions in the dorsolateral neocortex. The area of glycogen accumulation coincided with the known distribution ofN-methyld-aspartate (NMDA) glutamate receptors and, thus, GS may play important roles in NMDA receptor-mediated glutamate metabolism. The Alzheimer II type changes, however, did not correlate with NMDA-receptor distribution. These results indicate certain regionalizations in the roles of astrocytes and oligodendrocytes in glutamate and ammonia metabolisms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687370
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  • 2
    Electronic Resource
    Electronic Resource
    Pathogenesis of pili annulati (1988)
    Springer
    Archives of dermatological research 280 (1988), S. 308-318 
    Details
    ISSN: 1432-069X
    Keywords: Pili annulati ; Ultrastructure ; DACM staining ; Hair cortex ; Protein metabolism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Plucked scalp hairs and hair roots of pili annulati were examined to understand their pathogenesis. Stereoscopic examinations of hairs in transmitted light and/or reflected light and light microscopic surveys of the cross-sections of hairs confirmed that the cortical empty spaces appeared to be responsible to the unique dotted shiny appearance of the hairs seen by the unaided eyes under a refracted light. By transmission electron microscope, small vacuoles and dense bodies were observed in the cytoplasm of the differentiating cortical cells; subsequently, with increasing number of tonofilaments, an uneven distribution of free ribosomes occurred and abnormal spaces containing fine granular substances were formed in the cytoplasm of the cortical cells. Occasionally, extremely large cortical trichohyaline granules were found. In the keratinized hair, irregular empty spaces were present in the cortex of the abnormal hair segments. Histochemically, the keratinized cortex of the affected hairs always had more residual SH groups than the controls. Pili annulati may be a disorder of protein metabolism involving a partial dysfunction of cytoplasmic ribosomes, resulting in a lack of cortical keratin formation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00440605
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  • 3
    Electronic Resource
    Electronic Resource
    Simplified determination of serum cholesterol sulfate by gas-liquid chromatography combined with cyclohexylsilane-bonded phase column purification (1989)
    Springer
    Archives of dermatological research 281 (1989), S. 411-416 
    Details
    ISSN: 1432-069X
    Keywords: Cholesterol sulfate ; Gas-liquid chromatography ; Cyclohexylsilane-bonded phase column ; Recessive X-linked ichthyosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A new gas-liquid chromatographic (GLC) determination of cholesterol sulfate (CS) and dehydroepiandrosterone sulfate (DHEAS) for a biochemical diagnosis of recessive X-linked ichthyosis (RXLI) is described. Although the GLC method for determination of CS is known to be more sensitive than the thin layer chromatographic (TLC) method, the former method has not been widely employed because of its complicated pre-purification steps. The present method allows us to measure the serum levels of CS and DHEAS without tedious purification steps such as multiple conventional column chromatography and preparative thin layer chromatography. Sulfated steroids are rapidly purified with a commercially available mini disposable cyclohexylsilane-bonded phase (CH) column, CH BOND ELUT, and the purified steroids after desulfation are converted to water-resistant tert-butyldimethylsilyl ether derivatives for the GLC analysis on dual 2 m glass columns packed with 2% XE-60 on Chromosorb W. By the present method, serum CS concentrations in RXLI patients were shown to be about 10 times higher than those in patients with ichthyosis vulgaris, carriers of RXLI, and healthy subjects. This method is more suitable not only for a biochemical diagnosis of RXLI but also for studies on the metabolism of sulfated steroids than the previous time-consuming GLC methods.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00455327
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  • 4
    Electronic Resource
    Electronic Resource
    Effects of the mass screenings for neuroblastoma in Japan (1988)
    Springer
    European journal of pediatrics 147 (1988), S. 308-311 
    Details
    ISSN: 1432-1076
    Keywords: Neuroblastoma ; Mass screening
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Sixty-eight cases of neuroblastoma detected during mass screening being performed by 11 local self-governing bodies of Japan were studied concerning age, clinical stage, and survival rate. Their average ages at the first screening, at the beginning of thorough examination, and at the start of therapy were 215.7, 245.6, and 264.7 days, respectively. This screening, which is aimed at the 6-month-old infants is considered to be acceptable, on the grounds that the majority of the cases (95.6%) were asymptomatic at the time of thorough examination, that for most of the cases (98.5%) the initiation of therapy was at under 1 year of age, and that their 60-month survival rate was 87.5%. However, there seems to be room for discussion of the best age at which subjects should be screened, because the 68 cases included some patients already with advanced stages at the time of thorough examination, and because “false negative cases” were identified besides the 68 positive cases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00442702
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  • 5
    Electronic Resource
    Electronic Resource
    Observation of collision-induced-dipole absorption bands in strontium–rare-gas mixtures. I. The 5s–4d bands (1989)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 91 (1989), S. 4495-4498 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: Reduced absorption coefficients have been measured for the collision-induced-dipole (CID) absorption bands associated with the 5s–4d transition of atomic strontium perturbed by He, Ne, Ar, Kr, Xe, and Sr. The main CID absorption band, assigned to 5sΣ–4dΣ, extends from the position of the atomic 5s–4d transition towards the shorter-wavelength side for every perturber. For Xe and Kr, an additional small absorption band is seen at the foot of the atomic 5s–4d transition. The former 5sΣ–4dΣ band is interpreted to result from collisional mixing of the 5p state of atomic Sr into the molecular 4dΣ state for small internuclear separations, while the latter band is interpreted to result from the collisional quadrupole (strontium)–dipole (Xe or Kr) interaction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.456787
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  • 6
    Electronic Resource
    Electronic Resource
    Observation of collision-induced-dipole absorption bands in strontium–rare-gas mixtures. II. Bands involving high-lying states (1989)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 91 (1989), S. 4499-4503 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: We have observed many collision-induced-dipole (CID) absorption bands arising from the transitions between quasimolecular ground and high-lying (n≤10) states in the strontium–rare-gas systems. For each absorption band, we have measured the energy shift of the absorption peak from the energy of the correlating atomic forbidden transition and the effective oscillator strength per unit perturber density fCID/Np. The shift is roughly proportional to the electron scattering length L0 for each rare-gas atom, whereas the fCID/Np is roughly proportional to L20. The shift decreases in general as the principal quantum number n increases, and increases as one goes from the s state to the d state, and to the degenerate manifold state with l≥3. These general features of the shift and fCID/Np are consistent with the predictions by a simple Fermi-potential model, suggesting the important role of the interaction between a Rydberg electron and a rare-gas atom in the CID absorption processes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.456788
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  • 7
    Electronic Resource
    Electronic Resource
    Generalized eruptive histiocytoma: an ultrastructural study (1987)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of cutaneous pathology 14 (1987), S. 0 
    Details
    ISSN: 1600-0560
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A case of generalized eruptive histiocytoma (GEH) was evaluated and examined histopathologically and ultrastructurally. A 24-year-old male had an episode of high fever and drug-induced eruption prior to the appearance of multiple skin lesions. Uniform, red to dark-red papular lesions appeared on his cheeks and then became generalized. The lesions were composed of a massive dermal infiltrate of histiocytes, which had oval nuclei and amphophilic cytoplasm. The cytoplasm contained unique annular structures, myeloid bodies and vacuoles. The specificity of these structures is as yet unknown. Reactive stimulation rather than neoplastic proliferation may be a causative factor in GEH.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0560.1987.tb00480.x
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  • 8
    Electronic Resource
    Electronic Resource
    Non-Hodgkin lymphoma of the skin excluding mycosis fungoides and cutaneous involvement of adult T-cell leukemia/lymphoma (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of cutaneous pathology 15 (1988), S. 0 
    Details
    ISSN: 1600-0560
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Forty-nine cases of cutaneous malignant lymphoma were reviewed in order to analyze the clinicopathological features of these neoplasms. Excluding 13 cases of mycosis fungoides and 4 cases of cutaneous involvement of proven adult T-cell lymphoma/leukemia, the remaining 32 cases were further classified according to their pathological and clinical features. There were 12 primary cutaneous lymphomas, 15 cases of secondary cutaneous involvement of systemic lymphoma, and 5 cases of concurrent skin and lymph node involvement. Histologically, large cell lymphoma predominated in both primary and secondary cutaneous lymphomas. Immunohistochemical study using monoclonal antibodies reactive with B- and T-cells in paraffin sections revealed the cellular lineage in 30 cases. Nineteen cases were of T-cell origin and 11 cases were of B-cell derivation. The prognosis of these patients was rather poor; 25 patients died within 5 years. The predominance of T-cell lymphoma contrasts with a higher frequency of cutaneous B-cell lymphoma in Western countries. As the clinicopathological features of cutaneous lymphomas are diverse, it is suggested that cutaneous lymphomas should be classified and studied in a similar way to their nodal counterparts.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0560.1988.tb00543.x
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  • 9
    Electronic Resource
    Electronic Resource
    High-resolution time-of-flight methods for studies on ionic fragmentation of molecules : INTERNATIONAL CONFERENCE ON SYNCHROTRON RADIATION INSTRUMENTATION (1989)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 60 (1989), S. 2193-2196 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: The design and operation of the time-of-flight (TOF) mass spectrometer developed for ionic photofragmentation studies of molecules is described. Characteristics are summarized for three different operation modes of the TOF spectrometer; a pulse mode, a photoelectron–photoion coincidence mode, and a photoion–photoion coincidence mode. Experimental results for SiH4 are demonstrated as an example for the performance of the apparatus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1140819
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  • 10
    Electronic Resource
    Electronic Resource
    Optical and thermal analyses on multilayered thin films of a phase-change optical recording disk (1989)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 66 (1989), S. 1045-1050 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: A computer simulation method to study a laser-induced transient temperature profile of a multilayered phase-change optical recording disk (PCORD) has been developed. The simulation program consists of two parts. One part is an optical analysis program based on the optical characteristic matrix method, and the other is a thermal analysis program based on the finite-element method. A new estimation method for thermal conductivity of recording films was proposed. The estimated thermal conductivity of the thin-film recording media was found to be 50% lower than that of the bulk. Reflectivity, absorbance, and temperature values obtained with this simulation method were compared with those measured by a spectrophotometer and an infrared radiation thermometer when the samples were irradiated in an Ar+ laser beam. The accuracy using this simulator was within 8% for reflectivity and absorbance and within 10% for temperature. A method of optimizing the laser-absorbing layer was studied. With this method simulations showed that the PCORD had a maximum contrast ratio and minimum recording time when thickness, thermal conductivity, and complex refractive index of the laser-absorbing film were 60 nm, 4.2×10−3 W/cm °C, and 2.6−i⋅0.0, respectively. This simulation could provide better film designs for PCORDs and the other optical disks of heat mode recording.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.344456
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