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  • 1
    Electronic Resource
    Electronic Resource
    Lyman-α, Lyman-α coincidence detection in the photodissociation of doubly excited molecular hydrogen into two H(2p) atoms (1988)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 88 (1988), S. 3016-3021 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: Photodissociation processes of the doubly excited states of H2 into H(2p)+H(2p) have been studied using a coincidence detection of two Lyman-α photons. Coincidence spectra have been measured in the energy region of 29.0–36.0 eV. The intensity of the observed coincidence peak corresponding to two Lyman-α photons increases with increasing energy from its threshold which is about 29 eV. The main precursor of the two H(2p) atoms is assigned to the doubly excited Q2 1Πu state.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.453943
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Suppression of deprivation-induced water intake in the rat by opioid antagonists: central sites of action (1987)
    Springer
    Psychopharmacology 91 (1987), S. 279-284 
    Details
    ISSN: 1432-2072
    Keywords: Naltrexone methobromide ; Water intake ; Paraventricular hypothalamic nucleus ; Supraoptic hypothalamic nucleus ; Opiate antagonist
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of naltrexone methobromide, a quaternary derivative of the opioid antagonist naltrexone, were investigated on deprivation (24 h)-induced water intake in the unilaterally cannulated rats. Naltrexone methobromide reduced post-deprivational water intake with an ED50 of 7.3 μg when tested at 30 min (peak effect) after intracere-broventricular administration. It also dose-dependently (0.3–10 μg) depressed water intake, with peak effects at 15 min, after microinjection into the paraventricular hypothalamic nucleus and into the supraoptic hypothalamic nucleus. The drug did not produce any other effects on behaviors. The ED50s were 1.4 μg when given into the paraventricular nucleus, and 3.3 μg when given into the supraoptic nucleus, respectively. Although injections of higher doses (1.0, 3.0 and/or 10 μg) of the drug into the preoptic area, zona incerta, and corpus callosum significantly suppressed water intake, other behavioral manifestations, such as rotational behaviors, convulsions, body shakes, head swaying, and/or backward locomotion were manifested simultaneously with the reduction in drinking. When injected into the lateral hypothalamic area, water intake was not significantly affected by the drug. These findings suggest that the paraventricular and supraoptic hypothalamic nuclei are important sites of action in the naltrexone-induced suppression of water intake.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00518177
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Morphine-like discriminative stimulus effects of opioid peptides: possible modulatory role ofd-Ala2-d-Leu5-enkephalin (DADL) and dynorphin A(1-13) (1988)
    Springer
    Psychopharmacology 94 (1988), S. 32-37 
    Details
    ISSN: 1432-2072
    Keywords: Opioid peptides ; Discriminative stimulus effects ; Opioid receptor subtypes ; Morphine ; Dynorphin A(1-13) ; d-Ala2-d-Leu5-enkephalin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The role of the different opioid receptors was studied in rats trained to discriminate SC injections of 3.0 mg/kg morphine from saline by tests for generalization to graded doses of morphine and receptor-selective peptides administered into the lateral cerebral ventricle. Dose-dependent morphine-like stimulus effects were produced over a wide range of doses (0.001–30 μg), depending upon ligand and animal, by morphine, by themu-selective peptides DAGO[d-Ala2-NMePhe4-Gly(ol)-enkephalin] and FK33824[d-Ala2,NMePhe4-Met(O)5-(ol)-enkephalin], and by thedelta-selective peptide, DADL[d-Ala2,d-Leu5enkephalin]. The order of relative potency of these substances was: FK33824〉DAGO〉morphine〉DADL. In contrast, DPLPE[d-Pen2,l-Pen5)enkephalin], which has much greaterdelta receptor selectivity than does DADL, and dynorphin A(1-13) (0.1–10 μg), akappa-receptor agonist, engendered choice responding appropriate for saline. When 1.0 μg DADL, a dose lacking morphine-like discriminative effects, was administered concurrently with SC morphine, the stimulus effects of morphine were potentiated. Concurrent administration of 10 μg dynorphin A(1-13) and morphine attenuated the stimulus effects of morphine inconsistently. These results support previous findings thatmu-opioid receptors are of primary importance in mediating the morphine-like discriminative effects of opioid peptides. They also suggest that morphine-like discriminative effects can be modulated by other types of opioid receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00735877
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    Paper (German National Licenses)
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