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  • 1980-1984  (3)
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Material
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Year
  • 1
    Electronic Resource
    Electronic Resource
    Histamine uptake and metabolism in intact isolated parietal cells (1981)
    Springer
    Inflammation research 11 (1981), S. 223-227 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract 3H-Histamine binding, uptake and metabolism were investigated in intact isolated and enriched parietal cells from the dog and guinea pig. Histamine uptake was sodium dependent and followed by intracellular metabolism. The only metabolite that was detected and extracted from cytosol has been identified by TLC to beN r-methylhistamine. The histamineN-methyltransferase activity appeared to be sodium dependent and was inhibited by mepyramine and chlorpromazine, and also by higher concentrations (10−4–10−3 mol/l) of cimetidine. Two blockers of the sodium channel, amiloride and aminoguanidine, also reduced the enzyme activity by an as yet unknown mechanism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01967618
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Binding studies with3H-atropine in intact isolated guinea pig gastric mucosal cells (1980)
    Springer
    Inflammation research 10 (1980), S. 192-194 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract 3H-atropine binding was studied in isolated intact guinea pig gastric mucosal cells and has been shown to be saturable. Scatchard plots of the binding system calculated under the assumption of only one binding site revealedK D values for the parietal cell enriched population of 1.25×10−6 mol/l and 1.38×10−6 mol/l for the nonparietal cells. The results show that in the gastric mucosa both parietal and nonparietal cells contain cholinergic receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02024212
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Histidine decarboxylase inhibition byO-methyl-3(+)catechin and gastric acid secretion in the cat (1983)
    Springer
    Inflammation research 13 (1983), S. 249-251 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In the conscious cat the histidine decarboxylase inhibitorO-methyl-3(+)catechin (Zy 15029) promoted a dose-dependent atropine-sensitive increase in basal acid output. Gastric acid secretion stimulated by food or insulin at different time intervals after pretreatment with Zy 15029 was dose and time dependently diminished up to 70% whereas acid output following pentagastrin stimulation was not reduced by doses effective against the former two stimuli. Only a high dose, which due to side effects has to be claimed as not tolerable in the cat, reduced acid output by about 40%, when application of Zy 15029 and stimulation were 90 min apart. It is suggested that in the cat gastric acid response following the three different stimuli was at least in part but to a variable extent mediated by endogenous histamine. Dose-dependent side effects of Zy 15029 might have been due to histidine decarboxylase inhibition in brain and changes in histaminergic neutrotransmission.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01967344
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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