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  • 1
    Electronic Resource
    Electronic Resource
    The photoreceptor cell in the pineal organ of the Japanese common newt (1982)
    Springer
    Cellular and molecular life sciences 38 (1982), S. 1450-1451 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The photoreceptor cells in the pineal organ of the Japanese common newt are similar to typical vertebrate photoreceptors. It is supposed that the cells are responsible for the entrainment of locomotor rhythms as a consequence of their response to light.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01955763
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  • 2
    Electronic Resource
    Electronic Resource
    Follow-up study of a nation-wide neonatal metabolic screening program in Japan (1984)
    Springer
    European journal of pediatrics 142 (1984), S. 204-207 
    Details
    ISSN: 1432-1076
    Keywords: Neonatal screening ; Phenylketonuria ; Maple syrup urine disease ; Homocystinuria ; Galactosemia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A nationwide neonatal sreening program for phenylketonuria (PKU), maple syrup urine disease (MSUD), homocystinuria, histidinemia and galactosemia was started in Japan in 1977. The total number of infants screened had reached 6,311,754 by March, 1982. A follow-up study revealed the incidence of the disease in Japan: 1/108,823 for PKU; 1/450,840 for hyperphenylalaninemia (HPA); 1/1,577,939 for biopterin deficiency; 1/525,980 for MSUD; 1/1,051,959 for homocystinuria; 1/8,371 for histidinemia, and 1/788,969 for galactosemia type 1. The incidences of PKU, HPA, homocystinuria, and galactosemia (type 1) were found to be markedly low in Japan as compared with those in Caucasian countries. There was no great difference in the incidence of MSUD between both. On the other hand, the incidence of histidinemia was higher in Japan. It was found that most of the patients with PKU, HPA, MSUD, homocystinuria, or galactosemia are developing normally due to the early initiation of dietary treatment. These results clearly indicate that the neonatal mass screening program plays a great role in preventing the occurrence of handicapped children.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00442450
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  • 3
    Electronic Resource
    Electronic Resource
    Acute and long-term hypotensive effects and plasma concentrations of nifedipine in patients with essential hypertension (1982)
    Springer
    European journal of clinical pharmacology 23 (1982), S. 197-201 
    Details
    ISSN: 1432-1041
    Keywords: nifedipine ; hypertension ; low dose ; plasma concentration ; acute and long-term treatment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The acute and long-term hypotensive effects of low doses of nifedipine, and the correlation between the fall in the blood pressure (BP) and the plasma nifedipine concentration, were investigated in patients with essential hypertension. The oral administration of nifedipine 5 mg rapidly decreased BP from 163±22/101±10 to 127±12/82±9 mmHg (mean±SD; p〈0.001), and increased heart rate from 72±8 to 76±6 beats/min (p〈0.05), plasma renin activity rose from 1.2±0.6 to 1.4±0.8 ng/ml/h (p〈0.05), and plasma nifedipine concentration was 75.6±22.0 ng/ml 30 min after administration (n=7). The nifedipine concentration was significantly correlated both with the fall in BP (r=0.410, p〈0.02, n=31) and the rise in the heart rate (r=0.412, p〈0.02, n=31). Treatment with nifedipine 5 mg t.d.s. alone or in combination either with propranolol 10 mg t.d.s., or thiazide 1 tablet daily, or propranolol and thiazide, controlled BP in 36 patients during the 22 week study period. During the long-term nifedipine therapy, the plasma nifedipine level was significantly correlated with the fall in systolic (r=0.577, p〈0.01, n=20) and diastolic (r=0.595, p〈0.01, n=20) BP. It was concluded that the plasma nifedipine concentration could be correlated with the fall in BP, and that low doses of nifedipine, either as monotherapy or in combination, were effective in the acute and long-term treatment of patients with essential hypertension.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00547553
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  • 4
    Electronic Resource
    Electronic Resource
    Hypotensive effects of diltiazem to normals and essential hypertensives (1983)
    Springer
    European journal of clinical pharmacology 25 (1983), S. 475-480 
    Details
    ISSN: 1432-1041
    Keywords: hypotensive effect ; diltiazem ; plasma level ; normotension ; essential hypertension ; plasma renin ; arterial vasodilatation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The hypotensive effect of acute and long-term, intravenous and oral administration of the calcium antagonist, diltiazem, was investigated in 8 normotensive volunteers and 55 patients with essential hypertension. Diltiazem i.v. infusion of 45 mg/h (0.5 mg/min, then 1.0 mg/min, each for 30 min rapidly decreased both blood pressure (BP) from 164±22/98±8 to 144±15/86±9 mmHg (mean±SD) and total peripheral resistance from 32.6±8.4 to 25.3±5.4 mmHg/l/min (p〈0.001), and increased stroke volume from 58.2±9.5 to 64.2±8.6 ml/beat (p〈0.05). It altered neither heart rate nor cardiac output in the hypertensives (n=10). Oral diltiazem 60 mg rapidly decreased BP from 155±10/103±6 to 142±12/90±8 mmHg after 3 hours (p〈0.01/p〈0.001) in hypertensives (n=8), but not in normotensives (n=8). Diltiazem 90 mg p.o. decreased BP from 157±15/102±9 to 129±13/83±8 mmHg (p〈0.01) in hypertensives (n=15), and reduced the heart rate from 71±8 to 65±8 beats/min (p〈0.01). The drug did not change plasma renin activity either in normotensives or hypertensives. The fall in diastolic BP was correlated with the plasma diltiazem concentration (r=0.910, n=6, p〈0.05). Long-term treatment with diltiazem 30mg t.d.s. decreased BP from 163±12/104±8 to 145±9/88±9 mmHg (p〈0.001, n=13), and 60mg t.d.s. decreased BP from 169±15/102±6 to 148±13/87±8 mmHg (p〈0.001, n=8), and significantly reduced the heart rate (p〈0.01) in hypertensives. Thus, the hypotensive action of diltiazem, which is due to arterial dilatation, is effective, either on intravenous or oral administration, during acute and long-term treatment of essential hypertension.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00542114
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  • 5
    Electronic Resource
    Electronic Resource
    The morphology and hardness of the nail in two cases of congenital onychoheterotopia (1984)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 110 (1984), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Two cases of congenital onychoheterotopia (ectopic nail) are described. In the first case electron microscopy showed spherical keratohyalin granules, and cytoplasmic desmosomes were seen in the keratinocytes of the nail matrix. The ectopic nail differed from the normal nail in the widening of the angle between the nail matrix and proximal nail fold, and in its radial growth to the skin surface. In the second case, clippings of the ectopic nail were taken and their hardness proved to be very similar to that of normal nails.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1984.tb04710.x
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  • 6
    Electronic Resource
    Electronic Resource
    Tick bite: two cases studied by scanning electron microscopy (1984)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 110 (1984), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The attachment of ticks to human skin has been studied by scanning electron microscopy. Intact specimens of Ixodes ovatus and Ixodes persulcatus were examined, and we also studied the skin of two patients who had been bitten by these two species. In the first case, the remains of the tick were visible and a homogeneous cement-like substance was observed on the dorsal hypostome and in the dermis, suggesting that the tick attaches itself to the host skin by a secretion. In the second case, the apices of some denticles of the hypostome were chipped. Two months later, the skin which the tick had attacked was biopsied and yellowish-brown particles, probably derived from the denticles, were seen in foreign body giant cells in the dermis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1984.tb07473.x
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  • 7
    Electronic Resource
    Electronic Resource
    Improvement of β-Amylase Production and Characterization of Polypepton Fraction Effective for β-Amylase Production (1984)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 434 (1984), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1984.tb29844.x
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  • 8
    Electronic Resource
    Electronic Resource
    Structure of (1-methyluracilato)silver(I), [Ag(C5H5N2O2)] (1984)
    Oxford [u.a.] : International Union of Crystallography (IUCr)
    Acta crystallographica 40 (1984), S. 775-778 
    Details
    ISSN: 1600-5759
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0108270184005692
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  • 9
    Electronic Resource
    Electronic Resource
    Structure of bis(9-methylhypoxanthine)silver(I) nitrate dihydrate, [Ag(C6H6N4O)2](NO3).2H2O (1984)
    Oxford [u.a.] : International Union of Crystallography (IUCr)
    Acta crystallographica 40 (1984), S. 772-775 
    Details
    ISSN: 1600-5759
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0108270184005680
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  • 10
    Electronic Resource
    Electronic Resource
    Fluorine geochemistry of basaltic rocks from continental and oceanic regions and petrogenetic application (1981)
    Springer
    Contributions to mineralogy and petrology 76 (1981), S. 53-59 
    Details
    ISSN: 1432-0967
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract Fluorine contents in about 300 samples of various types of basalts and related rocks from continental (southwestern U.S.A.; Zaire; Deccan and South Africa) and oceanic regions (Hawaii and Mid-Atlantic Ridge between 23° N and 40° N) were determined by a selective ion-electrode method. Of all of the major components in these basaltic rocks, F shows good correlation only with K2O. It increases regularly from tholeiite to perpotassic basalt on continents, and from tholeiite to nephelinite on Hawaii. In the F-K2O diagram all the basaltic rocks from continents and Hawaii plot between the origin of the coordinate axes and the field of phlogopite in peridotite xenoliths in South African kimberlites. Accordingly, the major proportions of F, K2O and also H2O in these basaltic magmas are derived from phlogopite at the source regions in the upper mantle. On the other hand, F in abyssal tholeiites is relatively higher than that of the other tholeiites at equal K2O content, and it is suggested that most of F, K2O and H2O are derived from pargasites. When it is assumed that the upper mantle phlogopite contains about 10% K2O, 0.4% (0.3–0.5%) F and 4% H2O, H2O content in basaltic magmas from continental including island arc and oceanic island regions can be qualitatively estimated based on their proportions of K2O∶F∶H2O. Similarly, H2O content in abyssal basaltic rocks is also estimated on the basis of F∶H2O in pargasites (Table 2). A suite of Deccan tholeiites shows remarkable F enrichment with increasing K2O due to separation of anhydrous and K-free minerals during fractionation. F in tholeiitic and alkali basalt magmas in Hawaii also increases regularly with K2O during progressive fractionation until the later stages, where rhyodacite and trachyte exhibit a relative decrease owing to the effective subtraction of F-bearing amphibole and apatite in addition to anhydrous minerals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00373683
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