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  • 1
    Electronic Resource
    Electronic Resource
    Functions of peripheral-blood monocytes and granulocytes in cutaneous T-cell lymphoma (1982)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 107 (1982), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Granulocyte and monocyte functions (phagocytosis, intracellular killing, chemokinesis and chemotaxis) and the opsonic and chemotactic activity of the serum of twenty-two patients with cutaneous T-cell lymphoma were assessed. Granulocyte functions were within the normal control range in most cases. The monocyte functions showed more variation in the test results; in six out of twenty-two patients intracellular killing of Staphylococcus aureus was depressed and in four out of ten patients a disturbance in monocyte chemotaxis was found. Two patients with a decreased chemotactic response also had an impaired capacity to kill S. aureus. No correlation was found between the cell disturbance and susceptibility to infection, stage of the disease, or clinical course in these patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1982.tb00333.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Kinetics of Phagocytosis and Intracellular Killing of Staphytococcus aureus and Escherichia coli by Human Monocytes (1981)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 13 (1981), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Tie kinetic patterns of the phagocytosis and intracellular killing of Staphytococcus and Echerichia coli by monocytes were investigated separately to acquire more insight into the total process, i.e. from the ingestion to the death of the micro-organisms. Phagocytosis proved to be dependent on: (1) both the bacteria-to-monocyte ratio and the monocyte concentration; a concentration of at least 5 × 105 monocytes/ml proved necessary for the measurement of ingestion, whereas the rate of ingestion was found to be proportional to the number of extracellular bacteria until a maximum rate is reached, (2) the serum concentration in the incubation medium, which influenced both the rate of phagocytosis and the maximum number of bacteria taken up by one monocyte, and (3) the temperature, the highest rate of phagocytosis being reached at 37–41°C The intracellular killing proved to be dependent on: (1) the number of bacteria ingested; the rate of killing was proportional to the number of ingested bacteria until a maximum rate was reached; (2) the temperature, since a maximum rate of killing is only reached at 37–41°C: at tower and higher temperatures the rate of killing is lower, in the latter case due to inactivation of extracellular stimuli. These separate data on the ingestion and killing processes made it possible to compute the theoretical numbers of extracellular, viable intracellular, and total intracellular bacteria for a model system consisting of 5×106 monocytes, 5×106 bacteria, and 10% serum. These calculated values are in agreement with the experimental data.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1981.tb00122.x
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  • 3
    Electronic Resource
    Electronic Resource
    Method to Prove Ingestion of Particles by Macrophages with Light Microscopy (1980)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 12 (1980), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Research on phagocytosis is often hampered by the inability to distinguish whether (opsonized) particles have been ingested by phagocytes or are only attached to the surface of these cells. Treatment of the cells after phagocytosis to remove all extracellular particles makes it possible to evaluate phagocytosis with certainty by light microscopy. Opsonized erythrocytes attached to the macrophage surface are usually removed by hypotonic lysis. The present report describes the advantages of the use of lysostaphin to lyse Staphylococcus aureus and of xylene, chloroform or dioxane to dissolve polystyrene latex beads on the surface of peritoneal macrophages and embryonic fibroblasts. This procedure facilitates differentiation between professional and facultative phagocytes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1980.tb00066.x
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  • 4
    Electronic Resource
    Electronic Resource
    The Use of Lysostaphin in in Vitro Assays of Phagocyte Function: Adherence to and Penetration into Granulocytes (1982)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 15 (1982), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The usefulness of lysostaphin for the removal of cell-adherent and extracellular bacteria in assays performed to measure the intracellular killing of Straphylococcus aureus by granulocytes was investigated. The results showed that the adherence of lysosiaphin to the granulocyte surface is effectuated by a temperature-independent process and that bound lysostaphin is still microbicidal. Lysosiaphin also penetrates into the granulocytes by a temperature dependent process and kills ingested S. aureus intracellularly. Therefore, despite reports to the contrary in the literature, lysosiaphin is not a reliable agent for the removal of only extracellular S. aureus and should no longer be used in assays to determine the rate of intracellular killing by granulocytes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1982.tb00672.x
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  • 5
    Electronic Resource
    Electronic Resource
    Chemotactic and random movement of cord-blood granulocytes (1984)
    Springer
    Cellular and molecular life sciences 40 (1984), S. 1407-1410 
    Details
    ISSN: 1420-9071
    Keywords: Granulocytes, cord-blood ; random movement ; chemotactic responsiveness ; chemotaxis inhibitors ; cyclic nucleotide levels
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Chemotactic responsiveness and random movement of cord-blood granulocytes were studied with a modified Boyden's method. Cord-blood granulocytes were less active chemotactically than granulocytes from healthy children and adults, whereas the random filter movement of the cells from all three sources was about the same. In cord sera, concentrations of cell directed chemotaxis inhibitors were equal to those in sera from other age groups. Compared with the situation in healthy children and adults, the generation of chemotactic factors in cord-blood sera was impaired. This impairment was not related to an increased activity of chemotactic factor inactivators. Measurement of the cyclic nucleotide levels in granulocytes from cord-blood and from children belonging to various age groups revealed that the cord granulocytes have significantly lower concentrations of cAMP and cGMP, which could have been responsible for the decreased chemotactic responsiveness.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01951915
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Functions of granulocytes after allogeneic bone marrow transplantation (1981)
    Springer
    Annals of hematology 42 (1981), S. 253-257 
    Details
    ISSN: 1432-0584
    Keywords: Phagocytosis ; Intracellular killing ; Granulocytes ; Opsonins ; Bone marrow transplantation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The phagocytosis and intracellular killing by granulocytes as well as the opsonizing capacity of the serum were studied in 13 patients who had undergone allogeneic bone marrow transplantation. Phagocytosis was normal in all patients. A moderately impaired opsonic activity of the serum was found in two patients, who were investigated within 30 days after the transplantation. The intracellular killing was less than control values in two patients. In one patient this was probably due to the existence of a split chimerism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00996755
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  • 7
    Electronic Resource
    Electronic Resource
    Successful single antibiotic therapy in actinomyces septicemia and liver abscess (1982)
    Springer
    Infection 10 (1982), S. 287-289 
    Details
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Wir berichten über eine Septikämie mit Leberabszeß durchActinomyces sp. bei einem 36jährigen Mann. Die Infektion wurde höchstwahrscheinlich beim Ausweiden eines vom Patienten erlegten Stücks Wild erworben. Die Möglichkeit einer Infektion durchActinomyces bovis wird diskutiert. Der Leberabszeß wurde mit nicht-invasiven Methoden diagnostiziert. Die Therapie bestand aus hochdosiertem Penicillin, eine chirurgische Abszeßdrainage wurde nicht durchgeführt. Ein Rezidiv trat während einer dreieinhalbjährigen Nachbeobachtungszeit nicht auf. Bisher ist kein Fall beschrieben, in dem ein Leberabszeß durchActinomyces ohne chirurgischen Eingriff erfolgreich behandelt wurde.
    Notes: Summary We are reporting on a 36-year-old man with septicemia and a liver abscess due toActinomyces sp. The infection was most probably acquired while eviscerating a deer he had shot. The possibility of an infection involvingActinomyces bovis is discussed. The liver abscess was diagnosed on the basis of non-invasive procedures. Therapy consisted of high-dose penicillin without surgical drainage of the abscess. The infection did not recur during the three-and-a-half year follow-up period. No previous reports of successful antibiotic therapy for actinomycotic liver abscess without surgical procedures are known.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01640876
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  • 8
    Electronic Resource
    Electronic Resource
    Selective antimicrobial modulation of the intestinal flora (1984)
    Springer
    Infection 12 (1984), S. 1-4 
    Details
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01641014
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  • 9
    Electronic Resource
    Electronic Resource
    Possibilities and limitations of vaccination (1981)
    Springer
    Infection 9 (1981), S. 50-56 
    Details
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In der vorliegenden Arbeit werden die verschiedenen Faktoren der Wirtsabwehr einschließlich der Grundlagen der humoralen und zellulären Immunantwort beschrieben. Es folgt eine Diskussion der Prinzipien der Vakzination, dabei wird zwischen Routineimpfung, selektiver und elektiver Vakzination unterschieden. Für jede Art der Vakzination werden Beispiele angeführt. Zuletzt wird eine kurze Übersicht über die passive Immunisierung mit Gammaglobulin und Plasma gegeben.
    Notes: Summary This paper describes first the various host resistance factors, including the principles underlying humoral and cellular immune responses. Next the principles of vaccination are discussed, a distinction being made between routine, selective, and elective vaccination, and examples of each kind of vaccination are given. Finally, passive immunization with gammaglobulin and plasma is briefly reviewed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01640810
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    Paper (German National Licenses)
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  • 10
    Electronic Resource
    Electronic Resource
    The role of bacterial adherence in the pathogenesis of infective endocarditis (1982)
    Springer
    Infection 10 (1982), S. 196-198 
    Details
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Adhärenz von Bakterien infolge spezifischer Oberflächeneigenschaften ist möglicherweise ein pathogenetischer Faktor in der Entwicklung der bakteriellen Endokarditis. Bestimmte Bakterientypen sind selektiv bevorzugt an der Entstehung dieser Erkrankung beteiligt. Es kann angenommen werden, daß Adhärenz und pathogene Mechanismen in Wechselwirkung treten, was sich auf die Entstehung der Endokarditis fördernd oder hemmend auswirken könnte. Beispiele einer solchen Interaktion, die zur Pathogenese der bakteriellen Endokarditis beitragen könnte, sind Dextranbildung durch Streptokokken, Aktivierung des Gerinnungssystems durch Gewebethromboplastin der Monozyten und die Phagozytose von Bakterien von der Oberfläche der Vegetationen durch Granulozyten und Monozyten.
    Notes: Summary Bacterial adherence as a result of specific surface properties may be a contributory factor in the pathogenesis of bacterial endocarditis giving certain types of bacteria a selective advantage to cause this disease. Adherence could interact with other pathogenetic mechanisms, and this interaction could promote or hamper the development of endocarditis. Dextran production by streptococci, the activation of the clotting system by monocyte tissue thromboplastin, and phagocytic removal of bacteria from the vegetational surface by granulocytes and monocytes are examples of interacting mechanisms that could contribute to the pathogenesis of bacterial endocarditis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01640778
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