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  • 1
    Electronic Resource
    Electronic Resource
    The role of bacterial adherence in the pathogenesis of infective endocarditis (1982)
    Springer
    Infection 10 (1982), S. 196-198 
    Details
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Adhärenz von Bakterien infolge spezifischer Oberflächeneigenschaften ist möglicherweise ein pathogenetischer Faktor in der Entwicklung der bakteriellen Endokarditis. Bestimmte Bakterientypen sind selektiv bevorzugt an der Entstehung dieser Erkrankung beteiligt. Es kann angenommen werden, daß Adhärenz und pathogene Mechanismen in Wechselwirkung treten, was sich auf die Entstehung der Endokarditis fördernd oder hemmend auswirken könnte. Beispiele einer solchen Interaktion, die zur Pathogenese der bakteriellen Endokarditis beitragen könnte, sind Dextranbildung durch Streptokokken, Aktivierung des Gerinnungssystems durch Gewebethromboplastin der Monozyten und die Phagozytose von Bakterien von der Oberfläche der Vegetationen durch Granulozyten und Monozyten.
    Notes: Summary Bacterial adherence as a result of specific surface properties may be a contributory factor in the pathogenesis of bacterial endocarditis giving certain types of bacteria a selective advantage to cause this disease. Adherence could interact with other pathogenetic mechanisms, and this interaction could promote or hamper the development of endocarditis. Dextran production by streptococci, the activation of the clotting system by monocyte tissue thromboplastin, and phagocytic removal of bacteria from the vegetational surface by granulocytes and monocytes are examples of interacting mechanisms that could contribute to the pathogenesis of bacterial endocarditis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01640778
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of immunization on the induction and course of experimental streptococcus sanguis and staphylococcus epidermidis endocarditis (1980)
    Springer
    Infection 8 (1980), S. 267-274 
    Details
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Immunisierung von Kaninchen mitStreptococcus sanguis oderStaphylococcus epidermidis führt zur Bildung von spezifischen agglutinierenden und opsonierenden Antikörpern gegen den entsprechenden Mikroorganismus. Im Verlauf der bakteriellen Endocarditis entwickelten nicht immunisierte Kaninchen ebenfalls die jeweiligen Antikörperaktivitäten gegen den infizierenden Mikroorganismus, jedoch mit niedrigeren Spiegeln. Immunserum regte die Phagozytose in vitro an, aber es verstärkte, verglichen mit normalem Serum, nicht die intrazelluläre Abtötung der entsprechenden Bakterienstämme durch die gewonnenen Kaninchenmakrophagen. Die Anwesenheit spezifischer Antikörper nach Immunisierung schien beim Kaninchen keinen Einfluß auf die Induktion oder den Verlauf der Infektion von Endokardwucherungen mit Streptokokken oder Staphylokokken zu haben. Die Überlebenszeit war bei den immunisierten Kaninchen mit Endocarditis länger, wahrscheinlich infolge der geringergradigen Bakteriämie.
    Notes: Summary Immunization of rabbits withStreptococcus sanguis or Staphylococcus epidermidis results in specific agglutinating and opsonic antibodies against the corresponding micro-organisms. Non-immunized rabbits also developed these respective antibody activities against the infecting micro-organisms during the course of bacterial endocarditis, but at a lower level. Immune serum promoted phagocytosis in vitro but did not enhance intracellular killing of the corresponding bacterial strains by elicited rabbit peritoneal macrophages as compared with normal serum. The presence of specific antibodies in rabbits after immunization appeared to have no effect on the induction or course of streptococcal or staphylococcal infection of endocardial vegetations. The survival time of immunized rabbits with endocarditis was prolonged, probably due to a lower degree of bacteremia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01640917
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    The fine-thread method: lacrimation test for measuring ocular side-effects of drugs in the rat (1983)
    Springer
    Documenta ophthalmologica 56 (1983), S. 35-39 
    Details
    ISSN: 1573-2622
    Keywords: lacrimation ; fine-cotton-thread tear test ; atropine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Tear production was measured by means of the fine-cotton-thread method in rats. Sedation with hypnorm had no pharmacological effect on normal tear production. Daily oral administration of atropine which was comparable with the dose used for human adults on a drug-to-weight basis, resulted in a 60-percent reduction of tearing. Tearing returned to base-line levels after withdrawal of atropine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00154706
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Effect of Acetazolamide (Diamox®) on tear secretion (1985)
    Springer
    Documenta ophthalmologica 59 (1985), S. 77-80 
    Details
    ISSN: 1573-2622
    Keywords: diuretics ; tear fluid ; peroxidase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The side effects of acetazolamide (Diamox®) on lacrimation were measured in rats by means of the cotton-thread tear test. After a daily oral 1-mg dose (administered for five days), comparable to the dose used for adult humans on a drug-to-bodyweight basis, tear production remained unaffected but the lacrimal peroxidase secretion decreased by 60% of the baseline level. After withdrawal of acetazolamide the peroxidase secretion returned to the baseline level.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00162013
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    Paper (German National Licenses)
    Fulltext
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