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  • 1
    Electronic Resource
    Electronic Resource
    Problems in the use of polycarbonate diffusion chambers for syngeneic pancreatic islet transplantation in rats (1980)
    Springer
    Diabetologia 18 (1980), S. 313-317 
    Details
    ISSN: 1432-0428
    Keywords: Transplantation ; islets of Langerhans ; streptozotocin diabetes ; diffusion chambers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Islets of Langerhans have been enclosed in polycarbonate diffusion chambers and transplanted intraperitoneally to syngeneic streptozotocin diabetic rats. Direct implantation of 1100–1400 islets in these chambers failed to reverse diabetes during a period of 12 weeks, and viable islet tissue was not recoverable at the end of this period. Islets placed in chambers which had been implanted 3–12 weeks previously similarly failed to lower blood glucose of diabetic recipients, as a result of lack of survival of the islets. Insulin infusion into chambers previously implanted in vivo, I125 insulin diffusion studies in chambers recovered 6–8 weeks after implantation, and scanning electron microscopy of the recovered membranes all indicated that the pores were not totally occluded. The failure of islet transplantation via chambers in this simple syngeneic model has discouraging implications for their use as a means of avoiding allograft rejection.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00251012
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The mechanism of insulin secretion (1984)
    Springer
    Diabetologia 26 (1984), S. 319-327 
    Details
    ISSN: 1432-0428
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00266030
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Microtubules, microfilaments and insulin secretion (1982)
    Springer
    Diabetologia 22 (1982), S. 301-308 
    Details
    ISSN: 1432-0428
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00253571
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Book reviews (1981)
    Springer
    Diabetologia 21 (1981), S. 500-500 
    Details
    ISSN: 1432-0428
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00257795
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Insulin secretion: The effector system (1984)
    Springer
    Cellular and molecular life sciences 40 (1984), S. 1098-1105 
    Details
    ISSN: 1420-9071
    Keywords: Insulin secretion ; regulation of ; microtubule-granule interactions ; B-cell cytoskeleton ; exocytosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Conclusions Studies of the role of the microtubule-microfilamentous system in insulin secretion have been widened by continuing experimentation and analysis to provide a comprehensive working hypothesis which embraces ideas of the way in which the polymerization of microtubules and microfilaments may be regulated and how these cytoskeletal components may act together to enhance the process of granule movement. It is also possible to speculate about, but not yet to demonstrate, the way in which the activities of this effector system could be regulated by calcium and by cyclic AMP, which are essentially involved in the regulation of rates of secretion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01971457
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  • 6
    Electronic Resource
    Electronic Resource
    Effects of taxol and nocodazole on insulin secretion from isolated rat islets of Langerhans (1982)
    Springer
    Bioscience reports 2 (1982), S. 795-801 
    Details
    ISSN: 1573-4935
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Taxol, a promotor of microtubule polymerization, and nocodazole, which induces microtubule depolymerization, used at concentrations known to be specific for these effects in other cell types, were each shown to inhibit glucose-stimulated insulin secretion from isolated rat islets of Langerhans. These findings suggest that the dynamic regulation of microtubule polymerization-depolymerization in pancreatic B ceils may be important for insulin secretion via the microtubule-microfilamentous system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01114939
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  • 7
    Electronic Resource
    Electronic Resource
    Effects of monensin on biosynthesis and intracellular processing of proinsulin (1984)
    Springer
    Bioscience reports 4 (1984), S. 737-742 
    Details
    ISSN: 1573-4935
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Monensin, a specific sodium ionophore, has been shown to reduce glucose-induced proinsulin biosynthesis by 30% and to completely inhibit the intracellular conversion of proinsulin to insulin. Autoradiography of monensin-treated cells demonstrated the presence of large quantities of newly synthesized proteins in amorphous vesicles close to the Golgi complex of B ceils. The results suggest profound effects of monensin on biosynthesis and intracellular processing of proinsulin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01128814
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    Paper (German National Licenses)
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