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  • 1
    Electronic Resource
    Electronic Resource
    Demyelination in experimental canine distemper virus infection: Immunological, pathologic, and immunohistological studies (1982)
    Springer
    Acta neuropathologica 56 (1982), S. 285-293 
    Details
    ISSN: 1432-0533
    Keywords: Canine distemper encephalitis (CDE) ; Immunopathology ; Demyelination ; Immunoglobulin ; Local immune response
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary White matter lesions were induced in the brains of eight of nine dogs by means of experimental canine distemper virus (CDV) infection. Dogs were killed at 21, 24, 31, and 42 days after infection. Lymphocyte responsiveness to Con A and PHA stimulation in vitro was severely suppressed up to 31 days post infection (p.i.), followed by partial recovery as tested at 42 days p.i. Anti-CDV neutralizing antibody response was very weak in most dogs. There was a weak increase in antimyelin and antimyelin basic protein antibodies in most dogs during the course of the experiment. Dogs killed up to 31 days p.i. developed non-inflammatory demyclinating lesions in which no immunoglobulin could be detected. One of the three dogs that were killed at 42 days p.i. developed severe inflammatory demyelination. This was the only dog with a strong anti-MBP antibody response in the CSF and immunoglobulin demonstrated in demyelinating lesions. The present study supports previous observations that demyelination in acute CDV infection is not an immune mediated lesion but that these lesions may progress as a result of the local immune response. It is uncertain at this stage whether the local immune reaction specifically causes myelin destruction or whether bystander demyelination occurs in chronic CDE.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00691260
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Immunological and pathological findings in demyelinating encephalitis associated with canine distemper virus infection (1982)
    Springer
    Acta neuropathologica 56 (1982), S. 1-8 
    Details
    ISSN: 1432-0533
    Keywords: Canine distemper encephalitis (CDE) ; Immunopathology ; Demyelination ; Immunoglobulin ; Local immune response
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Nine dogs with canine distemper encephalitis (CDE) were examined with immunological techniques including demonstration of antibodies against canine distemper virus (CDV) in the serum and against myelin basic protein (MBP) in serum and in CSF. Mitogen stimulation tests of lymphocytes were also done. The brains were examined pathologically and immunoglobulin and C3 were demonstrated in lesions by means of immunohistological techniques. Six dogs with acute CDE had none or low antibody levels against CDV or MBP, and there was no immunoglobulin in demyelinating lesions. Some of these dogs had depressed lymphocyte mitogen responses. Two dogs with chronic CDE showed recovery of lymphocyte mitogen responses. One of these had a significant antibody response against CDV and MBP in the serum. Both dogs with chronic CDE had very high antibody titers against MBP in the CSF and demyelinating lesions contained immunoglobulin. These results suggest that acute demyelination in CDE is probably due to some direct viral activity and that the progression of demyelination in chronic CDE is associated with a local immune response.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00691174
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Phosphorylation of myelin basic protein by vaccinia virus (1980)
    Springer
    Medical microbiology and immunology 168 (1980), S. 103-110 
    Details
    ISSN: 1432-1831
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Vaccinia virus phosphorylates myelin basic protein in the myelin membrane in vitro. In the presence of vaccinia virus cores maximally 1.5 mol and in the presence of intact virus 0.7 mol phosphate residues were incorporated into 1 mol of myelin basic protein in the myelin membrane. The peptides of myelin basic protein which were phosphorylated by the vaccinia virus kinase were clearly all different from the peptides which were phosphorylated by the endogenous myelin protein kinase. The viral modification of the encephalitogenic protein and its significance to immunological events is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02121758
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Postanoxic myoclonus (1981)
    Springer
    Journal of neurology 225 (1981), S. 57-62 
    Details
    ISSN: 1432-1459
    Keywords: Myoclonus, postanoxic ; 5-Hydroxytryptophane ; 5-Hydroxyindolacetic acid ; Decarboxylase inhibitor ; Reflex loop
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wurde früher angenommen, daß der postanoxische Myoklonus durch eine Dysfunktion des ventro-lateralen thalamischen Nucleus bedingt ist. Diese Hypothese wurde durch verschiedene stereotaktische Studien in Frage gestellt. Neurochemische Untersuchungen, insbesondere die Messung von 5-Hydroxyindol-Essigsäure im Liquor öffnete den Weg zu neuen theoretischen und therapeutischen Möglichkeiten, Bahnen des serotoninergischen Systems zu beeinflussen. Ein typischer Fall wird vorgestellt, der unter einer Kombinationstherapie von 5-Hydroxytryptophan und einem Decarboxylase-Hemmer eine wesentliche Besserung zeigte. Die Pathogenese und therapeutische Möglichkeiten des postanoxischen Myoklonus werden diskutiert.
    Notes: Summary Postanoxic myoclonus was first accepted as being related to a dysfunction of the ventrolateral thalamic nucleus. Several stereotaxic studies have invalidated this hypothesis. The neurochemical approach, in particular the measure of 5-hydroxyindolacetic acid in the cerebrospinal fluid, has opened new theoretical and therapeutic possibilities involving serotoninergic pathways. A typical case is presented who improved markedly under a combined therapy with 5-hydroxytryptophan and a decarboxylase inhibitor. A review of the pathogenesis and therapeutic approach to postanoxic myoclonus is presented.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00313462
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    Paper (German National Licenses)
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