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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 6 (1982), S. 0 
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Alpha-I-antitrypsin immunoreactivity was demonstrated by immunofluorescence in epithelial cells of the normal human small intestine. Its presence was also confirmed in biopsies of patients with Crohn's disease. Specific fluorescence was observed in only four out of 14 adult patients with coeliac disease. These results implicate the human small intestinal epithelium as a possible source of alpha-I-antitrypsin. The absence of positive cells may have implications in the aetiology of coeliac disease.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-2307
    Keywords: Oesophageal epithelium ; Oesophagitis ; Normal biopsies ; langerhans cells ; Intraepithelial lymphocytes ; Monoclonal antibodies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Using monoclonal antibodies on fresh frozen endoscopically obtained oesophageal biopsies the distribution of Langerhans cells, B lymphocytes, and various subpopulations of T lymphocytes was studied in the normal human oesophageal mucosa and in oesophagitis. Identification of the lymphocytes was carried out by an immunoperoxidase technique using OKT3 (antihuman T cell antibody), OKT4 (antihuman helper T cell antibody), OKT8 (antihuman cytotoxic T cell) and OKT10 (antihuman null cell antibody). Identification of the Langerhans cells was carried out using an ATPase stain and OKIa (Ia like antigen) and OKT6 (antihuman thymocyte). In the normal oesophageal epithelium cytotoxic T lymphocytes are found as well as Ia positive Langerhans cells. Helper T lymphocytes and B lymphocytes are present mainly in the lamina propria. In oesophagitis an increase in Langerhans cells and cytotoxic T lymphocytes within the epithelium is found. From these findings it can be concluded that the oesophagus contains a reticuloepithelial system as well as a lymphocytic population which are a part of the gut-associated lymphoid tissue.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Digestive diseases and sciences 29 (1984), S. 219-224 
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The purpose of these experiments was to characterize the pattern of digestive myoelectric activity produced by four different test meals in dogs. A new approach for the analysis of the myoelectric activity of the small intestine was used. In contrast with methods dividing the tracings into present time periods, the present method respected the “motor entities,” hence the continuity, of the tracing. Two types of motor entities occurred: “activity units” which are groups of consecutive slow waves with spiking, and “rest units,” which are groups of consecutive slow waves without spiking. The frequency of occurrence and frequency of alternation of the various activity and rest units occurring during digestion was calculated. Digestive myoelectrical activity was characterized by the frequent occurrence and alternation of short activity and rest units. Three different patterns of digestive activity could be discriminated, ie, a fat, a protein and carbohydrate, and a canned food pattern.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Digestive diseases and sciences 29 (1984), S. 164-170 
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Arachis oil and a mixture of arachis oil with bile and pancreatic enzymes were infused into the duodenum and ilenum of dogs via surgically positioned catheters in order to study the mechanism of disruption of the migrating complex by intraluminally infused triglycerides, the importance of cholecystokinin and neurotensin in this event, and the pattern of digestive myoelectrical activity during fat digestion. When infused into the duodenum both arachis oil and the oil-bile-pancreatic enzyme mixture disrupted the migrating myoelectric complex (MMC). When infused into the ileum, only the oil-bile-pancreatic enzyme mixture disrupted the MMC. The duration of the disruption lasted as long as when the same amount of oil was administered orally. Triglyceride-induced digestive activity was characterized by the frequent alternation of short periods of spiking activity and short periods of quiescence. It is concluded that the triglyceride-induced disruption of the MMC-pattern is not caused by the triglyceride itself but by some emulsion or digestion product. We further suggest that the disruption is hormonally mediated and due to fatstimulated neurotensin, rather than cholecystokinin (CCK), release.
    Type of Medium: Electronic Resource
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