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  • Artikel: DFG Deutsche Nationallizenzen  (11)
  • 1995-1999  (9)
  • 1975-1979  (2)
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  • Artikel: DFG Deutsche Nationallizenzen  (11)
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  • 1
    Digitale Medien
    Digitale Medien
    A SENSITIVE FLUOROMETRIC METHOD FOR THE ESTIMATION OF 3,4-DIHYDROXYPHENYLETHYLENE GLYCOL SULPHATE IN BRAIN TISSUE (1978)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 30 (1978), S. 0 
    Details
    ISSN: 1471-4159
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Abstract— A simple fluorometric method for the estimation of endogenous 3,4-dihydroxyphenylethylene glycol sulphate (DOPEG-SO4) in brain tissue is described. DOPEG-SO4 was extracted from brain tissue with 0.4 n-perchloric acid and purified by column chromatography on QAE-Sephadex A-25, Cl− form. The isolated DOPEG-SO4 was hydrolysed by incubation with a purified preparation of sulphatase from Helix pomatia. The free DOPEG thus formed was further purified on a column of aluminium oxide and determined fluorometrically after conversion to a fluorescent compound by condensation with ethylenediamine.The sensitivity of this method was about 15 ng per perchloric acid extract applied on the column (3 ml) and the reproducibility was excellent, with a variation coefficient of 1.6% (n = 5). The concentration of DOPEG-SO4 in whole brains of rats, determined by the present method, was 79.3 ± 4.7 ng/g (mean ± S.D., n = 10) in terms of free DOPEG. No appreciable DOPEG-SO, was detected in the brains of mice and guinea-pigs.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1471-4159.1978.tb10488.x
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  • 2
    Digitale Medien
    Digitale Medien
    Comment on "Crystal structure and optical properties of polymorphic octasilacubane'' [Appl. Phys. Lett. 64, 2509 (1994)] (1995)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 66 (1995), S. 1291-1291 
    Details
    ISSN: 1077-3118
    Quelle: AIP Digital Archive
    Thema: Physik
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1063/1.113273
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  • 3
    Digitale Medien
    Digitale Medien
    An isolated silicon single chain end-grafted onto a substrate surface (1999)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 75 (1999), S. 781-783 
    Details
    ISSN: 1077-3118
    Quelle: AIP Digital Archive
    Thema: Physik
    Notizen: We report atomic force microscopy images of one-dimensional silicon chains (polysilanes) individually bonded to a substrate surface [quartz glass (SiO2), sapphire (Al2O3), and Si(111)]. The sample was prepared by a one-to-one chemical reaction between a reactive anchor of alkylbromide on the surface and a polysilanyl lithium. We observed dot images with variable densities which depended on the reactive anchor density. Each dot, with a diameter of about 20 nm and a height of about 5 nm, corresponded to an isolated single polysilane molecule with a collapsed structure typical of usual end-grafted polymers under poor solvent conditions. © 1999 American Institute of Physics.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1063/1.124511
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  • 4
    Digitale Medien
    Digitale Medien
    Mobilities of Li+ in Ne and in N2 and Na+ in SF6: Effect of inelastic energy loss (1996)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 105 (1996), S. 3031-3034 
    Details
    ISSN: 1089-7690
    Quelle: AIP Digital Archive
    Thema: Physik , Chemie und Pharmazie
    Notizen: Ion mobility measurements were made for Li+ in Ne and in N2 and Na+ in SF6 using a variable-temperature drift tube. The measurements were made by two different methods: variable-E/N method at constant T and variable-T method at constant E/N, where E, N, and T are the electric field strength, the gas number density, and the gas temperature, respectively. Two datasets were compared at the same effective temperature Teff, as calculated from the Wannier equation. For Li+ in Ne, the two datasets are put on a single curve in the range 150 K〈Teff〈10 000 K, indicating that the scaling rule holds well. However, for Li+ in N2 and Na+ in SF6 there exists a mobility difference between the two datasets, which is attributed to inelastic energy loss in the variable-E/N measurement. Using the modified Wannier equation developed by Viehland et al., we determined the inelastic energy loss factor for Na+ in SF6. © 1996 American Institute of Physics.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1063/1.472168
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  • 5
    Digitale Medien
    Digitale Medien
    ENZYMATIC CONVERSION OF HUMAN GROUP O RED CELLS INTO GROUP B ACTIVE CELLS BY α-D-GALACTOSYLTRANSFERASES OF SERA AND SALIVAS FROM GROUP B AND ITS VARIANT TYPES (1976)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 3 (1976), S. 0 
    Details
    ISSN: 1744-313X
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Biologie , Medizin
    Notizen: Salivas from group B secretor or non-secretor, acting on O red cells in the presence of UDP-galactose, each converted them into B active cells, which were agglutinated against anti-B human serum (1:512) at the titre of thirty-two-fold, while secretor or non-secretor group AB salivas converted O red cells into B active cells, which were agglutinated by anti-B human serum (1:512) at the titre of eight- to sixteen-fold. The results indicate that the α-galactosyltransferases which participate in the biosynthesis of group B substance are secreted in group B or AB salivas of both secretor and non-secretor types as well as in their sera.Agglutinabilities of enzymatically converted B-active red cells against anti-B human serum indicate that α-galactosyltransferase activities of both serum and saliva from a weak B (Bw) individual, who has weak B antigens in red cells and saliva, were lower than those of normal group B.The α-galactosyltransferase activities in group Bm sera were lower than those of normal group B, while the enzyme activities in salivas of group Bm were demonstrated to the same degree in normal group B salivas.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1744-313X.1976.tb00567.x
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  • 6
    Digitale Medien
    Digitale Medien
    γ-Mangostin, a novel type of 5-hydroxytryptamine 2A receptor antagonist (1997)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 357 (1997), S. 25-31 
    Details
    ISSN: 1432-1912
    Schlagwort(e): Key wordsγ-Mangostin ; 5-Hydroxytryptamine ; 5-Hydroxytryptamine 2A receptor antagonist ; Rabbit aorta ; Rat coronary ; Rabbit platelet
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract γ-Mangostin, purified from the fruit hull of the medicinal plant Garcinia mangostana caused a parallel rightwards shift of the concentration/response curve for the contraction elicited by 5-hydroxytryptamine (5-HT) in the rabbit aorta (pA2 = 8.2) without affecting the contractile responses to KCl, phenylephrine (α1) or histamine (H1). The perfusion pressure response of rat coronary artery to 5-HT (5-HT2A) was reduced concentration dependently by γ-mangostin (IC50 = 0.32 μM). 5-HT amplified, ADP-induced aggregation of rabbit platelets (5-HT2A) was inhibited by γ-mangostin (IC50 = 0.29 μM), whereas that induced by thrombin was not affected, nor did γ-mangostin affect 5-HT-induced contraction of the guinea-pig ileum (5-HT3)in the presence of 5-HT1, 5-HT2 and 5-HT4 receptor antagonists. Furthermore, 5-HT-induced contraction of the rat fundus (5-HT2B) and 5-HT-induced relaxation of the rabbit aorta in the presence of ketanserin (5-HT1) and carbachol-induced contraction of the guinea-pig ileum (muscarinic M3) were not affected by γ-mangostin (5 μM). γ-Mangostin inhibited [3H]spiperone binding to cultured rat aortic myocytes (IC50 = 3.5 nM). The K d for [3H]spiperone binding was increased by γ-mangostin (3 nM) from 11.7 to 27.4 nM without affecting B max. These results suggest that γ-mangostin is a novel competitive antagonist, free from a nitrogen atom, for the 5-HT2A receptors in vascular smooth muscles and platelets.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/PL00005134
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  • 7
    Digitale Medien
    Digitale Medien
    An inflammatory fibroid polyp of the esophagus concomitant with a superficial flat carcinoma (1999)
    Springer
    International journal of clinical oncology 4 (1999), S. 302-306 
    Details
    ISSN: 1437-7772
    Schlagwort(e): Key words Inflammatory fibroid polyp ; Esophageal tumor ; Esophageal mucosal carcinoma
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract We report a rare case of an inflammatory fibroid polyp (IFP) of the esophagus associated with an extensive early mucosal carcinoma. At esophagoscopy, a polypoid lesion 2 cm in length, and a non-stained area detected by the Lugol iodine spray staining method were found in the mid-thoracic portion, and esophagectomy was performed. Endoscopic polypectomy is thought to be useful for the diagnosis of IFP, but it should be kept in mind that IFP may be concomitant with carcinoma. Indeed, in our patient, early esophageal carcinoma was discovered because of the symptoms of dysphagia induced by the IFP.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s101470050073
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  • 8
    Digitale Medien
    Digitale Medien
    Anti-apoptotic actions of cycloheximide: blockade of programmed cell death or induction of programmed cell life? (1997)
    Springer
    Apoptosis 2 (1997), S. 257-264 
    Details
    ISSN: 1573-675X
    Schlagwort(e): Antioxidant enzymes ; apoptosis ; Bcl-2 ; free radicals ; NF-kB ; protein synthesis ; transcription factors
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Abstract Cycloheximide (CHX), long recognized for its ability to inhibit protein synthesis, has been widely employed in studies of cell death to the extent that prevention of cell death by CHX has been used as prima facie evidence for a subtype of apoptosis called ‘programmed cell death’. However, very rarely have investigators determined the effects of CHX on protein synthesis in their particular cell death paradigms. Recent findings are revealing alternative mechanisms of action of CHX that involve, ironically, stimulation of cytoprotective signalling pathways. For example, in embryonic rat hippocampal cell cultures CHX protects neurons against oxidative insults by a mechanism involving induction of neuroprotective gene products including Bcl-2. CHX induces increases in immediate early gene mRNA levels, and can activate several different kinases and transcription factors that are also activated by various insults and in response to anti-apoptotic growth factors. Concentrations of CHX that cause only a modest and/or transient decrease in over-all protein synthesis may prevent cell death by inducing cytoprotective signalling pathways (‘programmed cell life’), whereas higher concentrations of CHX may prevent cell death by blocking the expression of ‘death genes’. Establishing which of these anti-apoptotic mechanisms of action of CHX is operative in each cell death paradigm is clearly essential for proper interpretation of experimental results.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1026433019210
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  • 9
    Digitale Medien
    Digitale Medien
    Evaluation of 7 DNA markers (D1S80, HLA-DQα, LDLR, GYPA, HBGG, D7S8 and GC) in a Japanese population (1996)
    Springer
    International journal of legal medicine 109 (1996), S. 47-48 
    Details
    ISSN: 1437-1596
    Schlagwort(e): D1S80 ; D7S8 ; GC ; GYPA ; HBGG HLA-DQα ; LDLR
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin , Rechtswissenschaft
    Notizen: Abstract A Japanese population was tested for the 7 DNA markers D 1 S 80, HLA-DQα, low-density lipoprotein receptor (LDLR), glycophorin A (GYPA), hemoglobin G gammaglobin (HBGG), D7S8 and group specific component (GC). Each of these 7 markers was found to be useful for paternity testing and individual identification in a Japanese population.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01369603
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  • 10
    Digitale Medien
    Digitale Medien
    Methanogenic granular sludge formation in an upflow anaerobic sludge blanket reactir treating synthetic methanolic waste (1995)
    Springer
    World journal of microbiology and biotechnology 11 (1995), S. 631-637 
    Details
    ISSN: 1573-0972
    Schlagwort(e): Anaerobic treatment ; granular sludge characteristics ; granulation ; methanolic waste ; UASB reactor
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: Abstract A laboratory upflow anaerobic sludge blanket reactor, seeded with fine, suspended, bacterial floc with 1.76 g volatile suspended solids/l, was used to treat synthetic methanolic waste. After 180 days of continuous peration, granular sludge with discrete granules of 1 to 2 mm diam. was formed, with 52 g volatile suspended solids/l. Granules were brown, relatively soft and had a settling velocity of 1.61 cm/s. Extracellular polymeric matter extracted from the granular sludge had high carbohydrate content but low nucleic acid content. The ash of the granular sludge contained Na+, K+ and Mg2+ up to 15.0, 11.7 and 3.75 mg/g, respectively. Scanning and transmission electron microscopy revealed that the granular sludge was dominated by methanogens resembling Methanosarcina.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00361005
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