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  • 1
    Electronic Resource
    Electronic Resource
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Nuclear and Particle Science 41 (1991), S. 55-96 
    ISSN: 0163-8998
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Physics
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 33 (1991), S. 0 
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The specificity of the recognition of type II collagen (CII) by T cells in the DBA/1 mouse was analysed using fragments of chick and rat CII obtained by cyanogen bromide (CB) cleavage. Firstly DBA/1 mice were immunized with chick CB fragments 5, 8, 9, 10, 11 and 12. Ten days later the draining lymph node cells were cultured with rat and mouse CII and the proliferative response was determined by incorporation of [3H]thymidine All peptides were capable of triggering T cells recognizing rat CII but only CB9 immunized mice responded well to mouse CII. Secondly, lymph node cells from CBA/1 mice immunized with rat and mouse CII were cultured with the CB fragments including rat CB10 and CB11, and the proliferative response was determined. After immunization with rat CH, the response was strongly dominated by T cells recognizing CB11 with equal responses against chick and rat CB11. After immunization with mouse CH only rat CB10 gave a strong response. It is concluded that several epitopes on the CH molecule can be recognized by T cells in the DBA/1 mouse and that most of these epitopes are shared by rat and chick CH but not mouse CH. These epitopes exhibit strong immunodominance. In mice immunized with intact heterologous CH, the immunodominant response is directed against one or more epitopes on the CB11 fragment present on several heterologous CH but apparently not on mouse CH. In mice immunized with autologous CH the immunodominant response is directed against one or more epitopes on the CBl0 fragment present on rat and mouse CH. They are either absent in chick CH or located in the carboxyterminal end of the CB10 fragment where a cyanogen bromide cleavage site is present in chick CH but not in rat CH. These results suggest that the proposed importance of CBH in collagen-induced arthritis is due to activation of T cells reactive with heterologous CH only. These cells may be important for the induction of the strong auto-antibody-response after immunization with heterologous CH. Structures of importance for direct T cell involvement in the arthritic process and recognized by autoreactive T cells are suggested to be found on CB10.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-2307
    Keywords: Autopsy frequency ; Selection factors ; Stomach-colon-rectum cancer ; Lung-cancer ; Incidences
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A method for determining the incidence of malignancies of the stomach, colon, rectum, and lungs has been based on the frequency of the tumors in the autopsy material of the Institute of Pathology of the University of Heidelberg for the period 1900 to 1975. The main goal of this model is time independent selection of autopsy material indicated by an almost constant pattern for sex, average age at death, number of inhabitants, and number of autopsies. There is a relationship between incidence and autopsy frequency only when coding the diagnoses independently of their contributions to the cause of death. The results show a nearly constant incidence of stomach cancer, a steady incidence of colon and rectal cancer which, however, differs for men and women, and a large increase in the incidence of lung cancer.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Virchows Archiv 380 (1978), S. 155-162 
    ISSN: 1432-2307
    Keywords: Cancer registry ; Gastro-intestinal cancer ; Histo-pathologic diagnoses
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Vorzüge eines bevölkerungsbezogenen patho-anatomischen Registers werden diskutiert. In einem Gebiet mit einer guten medizinischen Versorgung hat ein Organregister für Magen/Darm-Tumoren, das sich auf histologisch-pathologische Diagnosen stützt, folgenden Vorteil: Es reduziert die Stellen, an denen die Daten erhoben werden, auf einige wenige und erreicht dadurch eine sehr hohe ZuverlÄssigkeit. Als Nachteil mu\ in Kauf genommen werden, da\ die histologisch-pathologischen und die klinischen Daten in zwei verschiedenen ArbeitsgÄngen erhoben werden müssen. Die Organisation und die geographische Situation des regionalen Registers für gastro-intestinale Tumoren in Nord-Baden werden beschrieben. Die Inzidenzen der Magen/Darm-Tumoren für die Jahre 1971 und 1975 in Nord-Baden (2.2 Millionen Einwohner) werden angegeben.
    Notes: Summary The advantages of a population-based registry are discussed. It is shown that a registry for gastro-intestinal cancer in a district with expert medical care based upon histo-pathological diagnosis, has the principal advantage that it limits the sites of material collection to a few effective contributors, thus providing highly accurate data. The disadvantage of collecting data by two separate steps should be tolerated. The geographic situation and the organization of the regional registry for gastro-intestinal cancer in North Baden are described and the incidences for these cancers for the years 1971–1975 are given for the population of 2.2 million.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Journal of cancer research and clinical oncology 93 (1979), S. 301-321 
    ISSN: 1432-1335
    Keywords: Gastro-intestinal cancer ; Incidence ; Cancer registry ; Gastrointestinaler Krebs ; Inzidenzen ; Tumorregister
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wurde die Inzidenz bösartiger Tumoren des Ösophagus, des Magens, des Dünndarms, des Kolons und des Rektums der Jahre 1971 bis 1977 im Regierungsbezirk Nordbaden, Bundesrepublik Deutschland, bestimmt. Die Relation der Inzidenzen zu den Ernährungsgewohnheiten der Bevölkerung wird kurz diskutiert. Sowohl die Altersverteilung der Inzidenzen als auch die altersstandardisierte Inzidenz und die Geschlechterverhältnisse zeigen deutliche Unterschiede der einzelnen Tumorlokalisationen. Die Inzidenz des Kolonkrebses steigt über den betrachteten Zeitraum besonders bei Frauen stark. Auch das Risiko, an Rektumtumoren zu erkranken, hat sich in den 7 Jahren erhöht. Die Ergebnisse des auf patho-anatomischer Basis arbeitenden Registers sind mit denen klinischer Register gut vergleichbar.
    Notes: Summary The incidences of the cancer of the oesophagus, stomach, small intestines, colon, and rectum for the years 1971–1977 in the regional district of North Baden, Federal Republic of Germany are presented and their relation to environmental factors are discussed briefly. The age specific incidence as well as the age standardized incidence and the sex ratios show remarkable differences due to the specific tumor localizations. The colon cancer incidence in the female population increases steeply during the period considered. The risk of developing rectal cancer also increases. The results of the pathoanatomic registry are well comparable with the data from clinical registries.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Annals of hematology 35 (1977), S. 241-246 
    ISSN: 1432-0584
    Keywords: Blutgerinnungsfaktoren ; Brandblasen ; Permeabilität (Kapillardurchlässigkeit) ; Coagulation factors ; Burn blisters ; Permeability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Following clotting factor assays were performed on the fluid of burn blisters of 11 patients with severe burns: Fibrinogen levels, Factor II, V, X and XIII, thrombin time, fibrin split products, plasminogen, antithrombin III, IgA, IgM, IgG, ethanol gelation test and total proteins. The results showed, that a quantity of Factor II, X and XIII, antithrombin III, plasminogen and IgG had left the circulation. On the contrary we found only small concentrations of Factor V, fibrinogen, IgM and IgA in the fluid of burn blisters. This distribution suggested that the losses of plasma proteins into the burn blisters were correlated to their concentration and their molecular weight. The decrease of plasma coagulation proteins during the first days after severe burns was probably partly due to losses through the walls of the vessels, because of the increased capillary permeability.
    Notes: Zusammenfassung Bei 11 Patienten werden folgende Untersuchungen des Brandblaseninhaltes durchgeführt: Fibrinogen, F.II, F.V, F.X und F.XIII, Fibrinogen-Fibrin-Spaltprodukte, Thrombinzeit, Plasminogen, Antithrombin III, IgA, IgM, IgG, Äthanol-Test und Gesamteiweiß. Die Ergebnisse zeigen, daß nach thermischem Trauma beträchtliche Mengen der Faktoren II, X und XIII, Antithrombin III, Plasminogen und IgG das Gefäßsystem verlassen, während F.V, Fibrinogen, IgM und IgA nur im geringen Ausmaß in der Blasenflüssigkeit nachweisbar sind. Nach diesem Verteilungsmuster der Brandblasenproteine muß angenommen werden, daß ihr Austritt aus dem Intravasalraum entsprechend ihrer Plasmakonzentration und Molekülgröße erfolgt. Der Abfall von Gerinnungsfaktoren bei Verbrennungspatienten in den ersten Tagen ihrer Erkrankung läßt sich somit zum Teil durch Verluste aus dem Gefäßsystem infolge der Permeabilitätssteigerung erklären.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Archives of dermatological research 257 (1977), S. 287-292 
    ISSN: 1432-069X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Spezifisch pathogenfreie Meerschweinchen wurden 15 Tage lang mit verschiedenen Dosen Fluocortolon behandelt. Die behandelten Tiere zeigten die gleiche prozentuale Gewichtszunahme wie die Kontrolltiere. Der Gesamt-Hydroxyprolingehalt der Haut war in beiden Gruppen gleich, ebenso der Hydroxyprolingehalt in verschiedenen Kollagenfraktionen. Mithin scheint Fluocortolon keinen spezifischen Effekt auf die Synthese oder den Abbau von Kollagen in der Meerschweinchenhaut zu haben. Auch in der Gewichtsentwicklung der unter definierten Tierstallbedingungen gehaltenen Tiere zeigte sich kein kataboler Effekt des Fluocortolons.
    Notes: Summary Specific pathogen free guinea pigs were treated with varying dosis of fluocortolone for 15 days. The treated animals showed the same per cent weight gain as the controls. The total hydroxyproline content of the skin and the hydroxyproline content in different collagen fractions was the same in treated and untreated animals. Thus fluocortolone seems to have no specific effect on the synthesis or the breakdown of collagen in the guinea pig skin. Also the physical development of the animals, kept under defined conditions, failed to show a catabolic effect of fluorcortolone.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1434-6052
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract A high-statistics measurement of the differential cross-sections for neutrino-iron scattering in the wide-band neutrino beam at the CERN SPS is presented. Nucleon structure functions are extracted and theirQ 2 evolution is compared with the predictions of quantum chromodynamics.
    Type of Medium: Electronic Resource
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