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  • 1
    ISSN: 1432-0533
    Keywords: mdx mouse ; Cathepsin L ; Macrophages ; Muscle structural proteins ; Proteolysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The amounts of non-collagen proteins (muscle structural proteins) and the activity of creatine kinase were significantly decreased in muscles of 28-day-old mdx mice. The activities of lysosomal thiol proteases such as cathepsins B and L were increased in muscles of mdx mice at as early as 10 days of age. Endogenous thiol proteinase inhibitor and various lysosomal hydrolases also showed increased activities. The localization of cathepsins B, H and L, and endogenous thiol proteinase inhibitor was investigated using the respective specific antibodies. While only invading macrophages were stained strongly with anticathepsin B and H, and anti-thiol proteinase inhibitor antibodies, cathepsin L was localized in muscle cells as well as in invading macrophages. Cathepsin L in muscle cells itself may initially degrade muscle structural proteins, before lysosomal thiol proteases, mainly derived from macrophages, degrade them in skeletal muscles of mdx mice.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 59 (1986), S. 3417-3420 
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Annealing behavior of secondary defects in 2-MeV boron ion-implanted (100) silicon has been investigated mainly through cross-sectional TEM observations. The maximum defect density is located at a mean depth of 3.2 μm from the surface and the location is 0.3 μm deeper than that of the projected range of boron ions. This defect position in the crystal is constant under all annealing conditions (e.g., a temperature range of between 700 and 1000 °C, annealing time of up to 6780 min at 1000 °C), although the vertical distribution width of defects changes with both annealing temperature and time.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford [u.a.] : International Union of Crystallography (IUCr)
    Acta crystallographica 43 (1987), S. 1786-1788 
    ISSN: 1600-5759
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Bulletin of environmental contamination and toxicology 22 (1979), S. 21-27 
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-1459
    Keywords: Motor-dominant neuropathy ; Carcinoma of the uterus ; Paraneoplastic syndrome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An autopsy case of a 56-year-old woman who had carcinoma of the corpus uteri and peripheral neuropathy with predominantly motor manifestations is described. The neurological abnormalities included subacute weakness of the limbs and loss of deep reflexes, which improved after the surgical removal of the uterine carcinoma. Neuropathologically, peripheral nerves mainly presented features of axonal degeneration with a mild loss of myelinated fibres. Anterior horns of the spinal cord showed central chromatolysis of the motor nerve cells and many spheroids without neuronal loss. Axonopathy of peripheral nerves was considered to be the main pathological process in this paraneoplastic syndrome.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary A population-based screening of newborns for the structural variants of fetal hemoglobin was carried out in Osaka Prefecture, Japan, by isoelectric focusing of globin chains using dried blood on filter paper. Of 80,000 newborns, 18 had α globin variants and 55 had γ globin variants. The incidence of γ globin variants (1/1,455) was much higher than that of α globin variants (1/4,444). Structural studies were then carried out on the abnormal γ globins in 36 samples, and revealed that 25 of them were Hb F Yamaguchi (AγT 80 Asp→Asn). The prevalence of this variant in Japanese was estimated to be as high as one per 2,100.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Colloid & polymer science 253 (1975), S. 905-915 
    ISSN: 1435-1536
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Description / Table of Contents: Zusammenfassung Eine allgemeine Formel für die Hochfrequenz-Grenzviskosität von verdünnten Polymerlösungen wird abgeleitet.N Perlen miteinander verknüpft mitN-1-Bindungen werden als Modell einer Polymerkette verwendet und die Viskosität berechnet von der Summe der Reibungsverluste aller Perlen. Dabei wird angenommen, daß die Kette frei durchströmt ist und die interne Rotation um die Bindung eingefroren ist, sowie daß die Perlen sich durch hydrodynamische Kräfte unter gewissen geometrischen Spannungen bewegen. Die abgeleitete Formel zeigt Gleichheit zu dem frequenzunabhängigen Term in derErpenbeck-Kirkwood-Theorie für die Viskosität des gleichen Modells. Die Formel wird angewendet auf freibewegliche Ketten, und es wird gezeigt, daß die intrinsic-Grenzviskosität der Kette 2,51 mal größer ist als die eines individuellen Segments, welches aus einer Einzelbindung mit zwei Halbperlen an jedem Ende besteht. Dieses Ergebnis wird mit gegebenen experimentellen Daten für die Hochfrequenzviskosität von Poly-L-glutamatsäure im Zustand der stückweisen Helix und von Polystyrol im hochviskosen Zustand verglichen.
    Notes: Summary A general formula for the high-frequency limiting viscosity of dilute solution of polymers is derived.N beads successively connected withN-1 bonds are employed as the model of a polymer chain and the viscosity is calculated from the sum of frictional loss of each beads, assuming that the chain is free-draining, the internal rotation of the bonds is frozen and the beads move by the hydrodynamic force under some geometrical constraints. The derived formula proves to be equivalent to the frequency-independent term in theErpenbeck-Kirkwood theory on the viscosity for the same model. The formula is applied to a freely jointed chain and it is shown that the intrinsic limiting viscosity of the chain is 2.51 times as large as that of the individual segment which consists of a single bond with two half beads at each ends. This result is compared with existing experimental values of the high-frequency viscosity of poly(L-glutamic acid) in the broken helix state and polystyrene in a highly viscous solvent.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Colloid & polymer science 253 (1975), S. 350-350 
    ISSN: 1435-1536
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    International journal of thermophysics 6 (1985), S. 251-265 
    ISSN: 1572-9567
    Keywords: alkanes ; hydrocarbons ; liquids ; mixing rule ; thermal conductivity ; transient hot-wire method
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The thermal conductivity of four pure normal paraffin hydrocarbons (C11, C14, C15, C16) and binary and ternary mixtures of three n-paraffin hydrocarbons (C7, C11, C16) have been measured in the temperature range from about 20 to 90°C at atmospheric pressure. Measurements have been performed with the aid of a fully automated transient hot-wire instrument. The accuracy of the reported data is estimated to be ±1.0 to ±1.5%. A new simple and practical equation, which can calculate the thermal conductivity of pure n-paraffin hydrocarbons (4≤n≤ 16) with the uncertainty of ±1%, has been correlated in terms of temperature and number of carbon atoms based on the present results including some other reliable data. Also, a mixing rule for the mixtures of n-paraffin hydrocarbons was proposed and was adequately confirmed by the present results within the experimental error.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Journal of inherited metabolic disease 11 (1988), S. 333-336 
    ISSN: 1573-2665
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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