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  • 1
    ISSN: 1520-5835
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 39 (1983), S. 604-606 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Human neutrophils preincubated with chemotactic factors showed enhanced OPZ-induced oxygen consumption. Maximum capacity of neutrophils to consume oxygen was found to be limited for both FMLP-treated cells and control cells. But with lower doses of OPZ, FMLP-treated cells consumed more oxygen than control cells.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 40 (1984), S. 380-381 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Lipid peroxides in rabbit erythrocytes and plasma were determined while anemia was induced by daily bleeding. They increased as reticulocytes increased and returned to normal with the morphological transformation to mature cells.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 38 (1982), S. 131-132 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Serum opsonic activity against zymosan was found to be decreased more markedly in highly diluted O type serum than in the other 3 types, among which no difference was noted. Heat-killed bacteria were equally well opsonized with any type of serum. This peculiar activity of O type serum against zymosan was not affected by the removal of isohemagglutinins. No inhibitory activity was demonstrable in O type serum.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Archives of dermatological research 276 (1984), S. 224-228 
    ISSN: 1432-069X
    Keywords: Scleroderma fibroblast ; Growth ; Lymphoid cell-derived fibroblast growth factor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Reactivity of scleroderma fibroblasts to lymphoid cell-derived fibroblast growth factor (FGF) was assessed in this study. The fibroblasts from the sclerotic lesion failed to respond to FGF, whereas those from scleroedematous lesions responded equally to normal fibroblast. Response of the fibroblast from sclerotic lesion was also lower than that of the fibroblast from mature scar. Fibroblasts obtained from three different layers of healthy skin, papillary dermis, reticular dermis, and reticular-subcutaneous layer, responded equally to FGF, whereas the fibroblast of reticular dermis from sclerotic lesion failed to respond to FGF. It is suggested that the fibroblast of reticuar dermis in scleroderma is variously activated by some unknown factors, so that they do not have enough reserve to respond to further stimuli.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 121 (1976), S. 279-285 
    ISSN: 1432-1076
    Keywords: Tryptic activity ; Chymotryptic activity ; Stool ; Prematures ; Sucklings ; Infants ; Diarrhoea ; Constipation ; Enteric bacteria
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bakterienproteasen verschiedener untersuchter Stämme der Proteus-, Pseudomonas aeruginosa-, Coli-, Streptococcus faecalis- und Bakteroidesgruppe stören die verwendeten Methoden zur Bestimmung der tryptischen und chymotryptischen Aktivität im Stuhl nicht. Beide innerhalb der Kollektive gemessenen Enzymaktivitäten folgen einer logarithmisch normalen Verteilung. Für die tryptische Aktivität liegt die untere Grenze der einfachen Standardabweichung in den Altersgruppen bei 51%, die obere bei 129% der Mittelwerte, entsprechend 60 und 170% für die chymotryptische Aktivität. Während für die chymotryptische Aktivität keine Unterschiede zwischen den 10 Altersgruppen mit insgesamt 157 weitestgehend gesunden Kindern bestehen, lassen sich für die tryptische Aktivität signifikante Differenzen zwischen der Gesamtgruppe der Frühgeborenen und älteren Kindern nachweisen. Auch die intraindividuellen täglichen Schwankungen der Enzymaktivitäten sind hoch und nur bei “Flaschenkindern” mit gleichbleibender Nahrung geringer. Bei Frühgeborenen und ganz jungen Säuglingen überwiegt die chymotryptische Aktivität, in späterem Alter die tryptische. Der Einfluß beschleunigter und verlangsamter Darmpassage auf die Streuung der Werte wird bei leichter Dyspepsie bzw. Obstipation als annähernd entsprechenden Modellen geprüft, wobei Vorbehalte bei der Interpretation dieser Untersuchungen zu machen sind. Die Beeinflussung der Enzymaktivitätswerte durch beide Passagestörungen geht nicht über die einfache Standardabweichung der jeweiligen Kontrollgruppe hinaus. Passagezeit und Nahrungseinfluß gehen neben anderen Faktoren in die Streuung der Enzymaktivitätswerte ein. Die starke Streuung der Aktivitätswerte im Rahmen der Altersgruppen setzt der Aussagekraft des Verfahrens engere Grenzen.
    Notes: Abstract Measurement of tryptic and chymotryptic activity in the faeces was not disturbed by bacterial proteolytic activity of different bacteria such as proteus, pseudomonas, coli, enterococci, bacteroides. Both activities within a group follow a logarithmic normal distribution. Lower limit of the standard deviation is 51%, upper limit 129% for tryptic activity, respectively 60 and 170% for chymotryptic activity. There were no differences in chymotryptic activity between the 10 age groups comprising 157 healthy children, whereas a significant difference could be found for tryptic activity between prematures and older children. Daily fluctuations of the enzyme activities are quite high in the same individual, and only reduced in “bottlefed” infants with constant nutrition. In prematures and very young infants chymotryptic activity predominates, later tryptic activity. Influence of increased and decreased bowel movements on deviation of the data was tested. There was, however, no real alteration of enzyme activity due to the bowel dysfunction beyond the standard deviation of the control groups. But passage time and nutrition have to be considered beside other factors in the wide distribution of the enzyme activities and the latter limits the value of this method.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-1076
    Keywords: Prematures ; Infants ; Children ; Cystic fibrosis ; Dystrophy ; Diagnosis ; Therapy ; Pancreatic enzyme substitution ; Fecal fat ; Digestion ; Feces ; Tryptic activity ; Chymotryptic activity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Unter gewissen Voraussetzungen ist die Bestimmung der tryptischen, besonders aber der chymotryptischen Aktivität im Stuhl vor allem während der ersten 4–6 Lebenswochen als wichtige Maßnahme in der Diagnostik der Mucoviscidosis anzusehen. Nach Absetzen des Pankreasenzympräparates fällt die tryptische und chymotryptische Aktivität des Stuhles Mucoviscidosis-kranker Kinder ab. Nach Verabfolgung des Präparates steigt die Enzymaktivität in Abhängigkeit von der Höhe der Dosis an und erreicht die Aktivitätswerte altersentsprechender gesunder Kinder. Ein Vergleich zwischen der proteolytischen Aktivität und dem Fettgehalt des Stuhles im Rahmen von Untersuchungsperioden ohne Gabe des Pankreasenzympräparates und bei unterschiedlicher Dosierung des Präparates läßt eine signifikante Korrelation der beiden Parameter vermissen. Es ist nicht erlaubt, aus einer hohen proteolytischen Aktivität des Stuhles auf eine entsprechend verminderte Fettausscheidung zu schließen, da sich fäkale proteolytische Aktivität und Fettausscheidung nicht umgekehrt proportional zueinander verhalten. Man kann deshalb die Höhe der proteolytischen Aktivität im Stuhl von Mucoviscidosis-Patienten nicht als allgemeinen Maßstab für die gesamte Verdauungsleistung bei Pankreasenzymsubstitution betrachten.
    Notes: Abstract Under certain conditions the determination of the tryptic activity, especially of the chymotryptic activity in the feces mostly of infants in the first 4–6 weeks of life is considered to be an important step in the diagnosis of cystic fibrosis. The tryptic and chymotryptic activity in the feces of children with cystic fibrosis declines when the substitution of pancreatic enzymes is stopped. On resubstitution, the activity rises in relation to the dose and attains the activity related to age as found in healthy children. A comparison of the proteolytic activity with the fat content of the feces during the study period without the enzyme substitution and during the period when the enzyme dosage varied showed no significant correlation. It is not possible to postulate a poor excretion of fats merely from the high proteolytic activity of the feces because the fecal proteolytic activity and the fat excretion are not inversely proportional to one another. For this reason, one cannot conclude that the grade of the proteolytic activity in the feces of patients with cystic fibrosis is a yardstick for the total digestive process when they are under pancreatic enzyme substitution.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-1076
    Keywords: Mitochondrial myopathic symdrome ; Lactic acidosis ; Endothelium ; Ultrastructural study
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The quadriceps femoris muscle and the muscularis mucosae of the rectum from two children with mitochondrial myopathic syndrome associated with lactic acidosis were studied by electron microscopy. Striking morphological abnormalities of mitochondria were noted not only in the skeletal but also in the smooth muscle cells. Endothelial cells of blood capillaries distributed in these affected muscles were so greatly swollen that the capillary lumen was almost occluded. In contrast, surface epithelial and glandular epithelial cells of the rectum contained normal mitochondria, and fenestrated capillaries in the propria mucosae remained intact. Long-term ischemia resulting from occlusive changes of the capillary wall may be responsible for the mitochondrial alterations of muscle cells.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 134 (1980), S. 121-124 
    ISSN: 1432-1076
    Keywords: Copper deficiency ; Erythrocyte superoxide dismutase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In a patient with typical copper deficiency, we found superoxide dismutase (SOD, 1.15.1.1) activity and copper in erythrocytes to be decreased to 52% and 46% of age-matched controls, respectively. However, these were not so markedly depleted as plasma copper (17%) or ceruloplasmin (20%). After copper replacement therapy, erythrocyte copper and SOD activity gradually returned to the control levels. Although certain abnormalities reported in copper deficiency in animals were expected, osmotic fragility of erythrocytes of the patient was normal and damage of the liver and heart were not a feature as far as could be determined by electrocardiography and routine laboratory examinations. Probably a decrease of SOD to this extent is not severe enough to lead to superoxide-induced damage.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Copenhagen : International Union of Crystallography (IUCr)
    Acta crystallographica 33 (1977), S. 925-928 
    ISSN: 1600-5740
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
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