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  • 1
    Electronic Resource
    Electronic Resource
    Comparative bioavailability of a microcrystalline theophylline tablet and uncoated aminophylline tablets (1979)
    Springer
    European journal of clinical pharmacology 16 (1979), S. 417-421 
    Details
    ISSN: 1432-1041
    Keywords: theophylline ; aminophylline ; bioavailability ; rapidly dissolving tablet
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The bioavailability of a rapidly dissolving tablet of theophylline and three brands of standard aminophylline tablets was estimated in a four way cross-over study involving 8 healthy adult volunteers. The relative extent of bioavailability as assessed by the measurement of the total area under the plasma concentration time curves showed no difference between the products (P〉0.05). Computed estimates of the rate of drug absorption were similar for all 4 products tested. The results indicate that the rapidly dissolving tablet offers no advantage in respect to rate and extent of absorption over conventional aminophylline tablets.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00568203
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  • 2
    Electronic Resource
    Electronic Resource
    Mk IN THREE GENERATIONS OF AN ENGLISH FAMILY (1979)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 6 (1979), S. 0 
    Details
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Mk was demonstrated in three generations of an English family. The propositus was detected as a result of an incompatibility in cross-match. General serological, biochemical and biophysical aspects have been studied.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1744-313X.1979.tb00694.x
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  • 3
    Electronic Resource
    Electronic Resource
    Ultrastructure of airways in children with asthma (1978)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 2 (1978), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: This study describes the histopathology and ultrastructure of bronchial mucosa in lung biopsies from two children with bronchial asthma in remission, and compares them with lung samples from two children who died in status asthmaticus. Light microscopy of all samples showed changes typical of bronchial asthma, e.g. mucus plugging, goblet cell hyperplasia, ‘thickening of bronchial basement membrane’, peribronchial smooth muscle hypertrophy and eosinophilic infiltration. Electron microscopy revealed that the mucus plugs consisted of moderately electron-dense floccular material containing degenerate epithelial cells, macrophages and cell fragments. The luminal surfaces of ciliated cells showed cytoplasmic blebs and abnormal cilia. Mast cells in various stages of degranulation were scattered between bronchial epithelial cells. The subepithelial hyaline layer, commonly referred to as “thickened basement membrane”, consisted of collagen fibrils in plexiform arrangement. The basement membrane proper appeared intact. These electron microscopic changes, particularly the presence of mast cells and subepithelial collagen deposits, were also found in autopsy samples. This combined light and electron microscopic study shows that marked, possibly irreversible changes may be present in the lungs of patients with severe bronchial asthma, even when they are asymptomatic. These pulmonary changes could be the direct consequence of mast cell activation and the release of various mediators. No evidence of immune complex deposition was found.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.1978.tb01735.x
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  • 4
    Electronic Resource
    Electronic Resource
    NORMAL PATTERNS OF FETAL ACTIVITY IN THE THIRD TRIMESTER (1979)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 86 (1979), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The incidence and frequency of fetal respiratory movements (FRM) and fetal trunk movements (FTM) were measured in 21 normal pregnancies between 28 and 39 weeks gestation. Fetal activity was assessed with a real-time ultrasound scanner and all observed movements were punched directly onto computer tape. Recordings were made for one hour in three over a 24 hour period, providing a total of 168 hours for analysis. The overall mean percentage incidence of FRM was 31 per cent at a mean breathing rate of 43 breaths/minute. The mean percentage incidence of FRM during the day (0800–1759 hours) was 37 per cent. The overall mean percentage incidence of FTM was 18 per cent with a mean of 29 moves per 30 minute observation period. The mean percentage incidence of FTM during the day (0800–1759 hours) was 16 per cent. There was a well-defined circadian variation in fetal activity with FRM peaking between 1900 and 2200 hours, and FTM between 2200 and 0100 hours. There was considerable variation in the amount of FRM and FTM recorded from hour to hour. Total fetal activity rarely fell below 10 per cent in any one recording period and this measurement may be a more useful clinical test of fetal well-being than FRM or FTM alone.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1979.tb10674.x
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  • 5
    Electronic Resource
    Electronic Resource
    Is Language Learned? (1975)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of philosophy of education 9 (1975), S. 0 
    Details
    ISSN: 1467-9752
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Education , Philosophy
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1467-9752.1975.tb00436.x
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  • 6
    Electronic Resource
    Electronic Resource
    Absorption and Re-distribution of Nitrogen during Growth and Development of Field Bean, Vicia faba (1976)
    Oxford, UK : Blackwell Publishing Ltd
    Physiologia plantarum 38 (1976), S. 0 
    Details
    ISSN: 1399-3054
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: The absorption of nitrate by field bean plants at different times of development was investigated to determine the distribution and subsequent utilization of N up to the maturity of the beans.Nodulated plants were grown in sand culture and pulse-labelled with 15NO3 for 4 short periods during development. Whole plants were sampled at intervals until maturity and analysed for total nitrogen and 15N.There was a rapid increase in the bean dry weight and total N after fruit set and, at maturity, the beans contained about three times as much N as had ever been in the rest of the plant. Nitrate absorption continued steadily throughout plant development but nodule N fixation made a progressively greater contribution to the total N in the plant. Over a quarter of the total 15N absorbed was found in the roots immediately after each treatment and little of this was subsequently translocated upwards in spite of the large increase in shoot N taking place. Above ground the most powerful “sink” for recently absorbed and redistributed N was initially the youngest vegetative tissue. However after fruit set competition developed between the growing tip and the developing beans until at the later stages the beans became the more powerful. Quantitatively redistribution made only a small contribution to bean N.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1399-3054.1976.tb04011.x
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  • 7
    Electronic Resource
    Electronic Resource
    The accuracy of predicted radioastronomical frequencies and the spectrum of hydroxyl (1979)
    [s.l.] : Nature Publishing Group
    Nature 278 (1979), S. 624-625 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] By considering ?-doubling of rotational levels of 2? states to be caused by second order perturbations, Van Vleck6 showed that the splitting may be expressed in terms of the parameters (2^ + 4) and q: (\p + q) and q: A^ = -(|p + 4)[l±(2-Y)/X](/ + |) =F(2〈j/A')(/ + 3/2)(/ + |)(/-i) ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/278624a0
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  • 8
    Electronic Resource
    Electronic Resource
    Marsupial-mouse cell hybrids containing fragments of the marsupial X chromosome (1979)
    Springer
    Somatic cell and molecular genetics 5 (1979), S. 481-489 
    Details
    ISSN: 1572-9931
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Hybrids were obtained from fusions of HPRT-deficient mouse fibroblasts and marsupial lymphocytes. These hybrids retained no identifiable marsupial chromosomes, but all expressed the marsupial form of HPRT. Half the clones also expressed marsupial PGK-A, and half of these also marsupial G6PD; no other marsupial allozyme markers were detected. Since G6PD is known to be sex linked in these species, we conclude thatHpt andPgk-A are also located on the X chromosome and the markers lie in the orderHpt-Pgk-A-Gpd.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01538882
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  • 9
    Electronic Resource
    Electronic Resource
    Expression of PGK-A in the Australian brush-tailed possum, Trichosurus vulpecula (Kerr), consistent with paternal X inactivation (1979)
    Springer
    Biochemical genetics 17 (1979), S. 325-332 
    Details
    ISSN: 1573-4927
    Keywords: marsupial ; phosphoglycerate kinase (PGK) ; isozymes ; dosage compensation ; paternal X inactivation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract An extensive survey of erythrocytes of marsupials other than kangaroos for electrophoretic variation in X-linked enzymes revealed two rare PGK-A phenotypes in the phalangerid Trichosurus vulpecula and one in Trichosurus caninus. Four putatively heterozygous females expressed only the variant allelic isozyme in some tissues but expressed a trace of the normal isozyme in others. A putatively hemizygous male expressed only the variant isozyme in all tissues. The phenotypic patterns were consistent with those observed in kangaroos known to exhibit partial or complete paternal X inactivation in cells of females. Two of the T. vulpecula were a mother and her female pouch young, further suggesting that paternal X inactivation occurs in T. vulpecula. This peculiar mechanism of dosage compensation may not be restricted to kangaroos.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00498972
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  • 10
    Electronic Resource
    Electronic Resource
    Possible autosomal inheritance of erythrocyte phosphoglycerate kinase a in echidnas (1978)
    Springer
    Biochemical genetics 16 (1978), S. 1031-1034 
    Details
    ISSN: 1573-4927
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00483753
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