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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Cell & tissue research 157 (1975), S. 535-540 
    ISSN: 1432-0878
    Keywords: Cerebral perivascular spaces ; Peroxidase ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Horseradish peroxidase, perfused into the lateral ventricle of chick brain, freely and slowly diffuses through the cerebral extracellular spaces. The layer of astrocytic end-feet surrounding blood capillaries does not constitute a barrier to the tracer which permeates the basal lamina, diffuses between the pericytic cells and finally accumulates in the intercellular space beneath the tight junctions between contiguous endothelial cells. No evidence was found for transport by micropinocytotic vesicles from the cerebral parenchyma to the capillary lumen.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Cell & tissue research 192 (1978), S. 299-308 
    ISSN: 1432-0878
    Keywords: Basal lamina biosynthesis ; Telencephalic capillaries ; Chick embryos ; 3H-proline autoradiography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Description / Table of Contents: Résumé L'élaboration de la lame basale des capillaires télencéphaliques a été étudiée en autoradiographie chez des embryons de Poulet âgés de 16 à 19 jours d'incubation. C'est au cours de cette période du développement que la basale des vaisseaux cérébraux est activement synthétisée. Les animaux furent sacrifiés 2,15, 40 et 180 min après le début de l'injection intraveineuse d'une solution de proline tritiée. L'identification des cellules participant à la synthèse de la basale est facilitée par le fait que l'hydroxylation de la proline en hydroxyproline y est réalisée. Nos observations nous permettent de suggérer une participation active des cellules endothéliales, des péricytes, et peut-être des cellules gliales, à l'élaboration de la lame basale. Les différentes étapes de cette synthèse ont lieu, par ordre chronologique, dans l'ergastoplasme, puis dans l'appareil de Golgi, avant que le produit élaboré ne soit libéré dans l'espace périvasculaire par exocytose.
    Notes: Summary The elaboration of the basal lamina of telencephalic capillaries has been studied by autoradiography in chick embryos from day 16 to 19 of incubation. The cerebral vascular basal lamina is actively synthesized during the period of these stages of development. The animals were sacrificed 2, 15, 40 and 180 min after intravenous injection of 3H-proline. The hydroxylation of proline to hydroxyproline in the “secretory” cells permits their identification. Our observations suggest that endothelial cells, pericytes and perhaps glial cells participate in this elaboration. The various stages of the synthesis are performed sequentially in the ergastoplasm and then in the Golgi apparatus before the secretory material is released by exocytosis.
    Type of Medium: Electronic Resource
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