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  • 1
    Electronic Resource
    Electronic Resource
    Ultrastructural study of Sertoli cells in rat seminiferous tubules during intrauterine life and the postnatal period (1980)
    Springer
    Anatomy and embryology 160 (1980), S. 11-27 
    Details
    ISSN: 1432-0568
    Keywords: Sertoli cells ; Rat ; Fetal and postnatal life ; Ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Sertoli cells have various functions: mechanical (creation of two compartments in the seminiferous tubules, migration of germinal cells), secretory (secretion of anti-Müllerian hormone, inhibin, androgen-binding-protein and estrogen) and phagocytic. We report an ultrastructural study of the rat Sertoli cell during maturation and consider possible correlations between the acquisition of certain morphological characteristics and certain functions. During fetal life, the Sertoli cell possesses differentiated zones of junction with the gonocytes and seems to have a role in the migration of the gonocytes towards the periphery of the seminiferous tubule. The Sertoli cell performs the phagocytosis of the gonocytes which degenerate during their migration, and seems to be the site of production of protein granules, whose presence can be related to the synthesis of anti-Müllerian hormone. After birth and before puberty, when the inclusions resembling secretory granules disappear, the Sertoli cell membranes in contact with spermatocytes II and spermatids differentiate, forming, through the differentiated junctional complexes, two compartments (adluminal and luminal) in the seminiferous tubules. Finally, they acquire the characteristics of active secretory cells, capable, in particular, of steroid synthesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315646
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  • 2
    Electronic Resource
    Electronic Resource
    Ultrastructural study of seminiferous tubules in the rat after prenatal irradiation (1982)
    Springer
    Anatomy and embryology 165 (1982), S. 425-435 
    Details
    ISSN: 1432-0568
    Keywords: Sertoli cells ; Development ; Ultrastructure ; Prenatal irradiation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Is the presence of germinal cells necessary for the Sertoli cells to acquire normal features? To respond to this question we have studied the development of the Sertoli cells in rats irradiated at the end of the foetal life. In the prenatal irradiated rats, the lumen of the seminiferous tubules appears later than in the control rats. The Sertoli cells show numerous flexuous apical processes, with central microtubule bundles. These processes regress progressively after the 40th day of life when the tubular lumen appears; numerous junctional complexes differentiate with the same structure as those of control animals. There are important dilatations of the intercellular spaces. The cytoplasmic organelles show a normal development up to the 40th day of life. After this period, the rough endoplasmic reticulum and the Golgi apparatus clearly regress while important dilatations appear in the smooth endoplasmic reticulum and persist in the adult animal. From the 35th day on, the basal lamina of the seminiferous tubules is irregular and multilayered. The differentiation of the Sertoli cells seems to be independent of the presence of germinal cells until the 40th day of life and presents several particularities; thereafter the Sertoli cells show signs of regression.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00305578
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  • 3
    Electronic Resource
    Electronic Resource
    Immunolocalization of albumin and transferrin in germ cells and Sertoli cells during rat gonadal morphogenesis and postnatal development of the testis (1994)
    Springer
    Cell & tissue research 276 (1994), S. 347-351 
    Details
    ISSN: 1432-0878
    Keywords: Albumin ; Transferrin ; Germ cells ; Sertoli cells ; Testis ; Immunocytochemistry ; Ontogenesis ; Rat (Wistar)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The localization of albumin and transferrin was examined immunohistochemically in germ cells and Sertoli cells during rat gonadal morphogenesis and postnatal development of the testis. These proteins appeared as early as the 13th day of gestation in migrating primordial germ cells before Sertoli cell differentiation. In the fetal testis, strong immunoreactivity was only detected in the gonocytes. In the prepubertal testis, spermatogonia, primary spermatocytes, and some Sertoli cells accumulate albumin and transferrin. At puberty, different patterns of immunostaining of the germ cells were observed at the various stages of the cycle of the seminiferous epithelium. Diplotene spermatocytes at stage XIII, spermatocytes in division at stage XIV, and round spermatids at stages IV–VIII showed maximal staining. Labeling was evident in the cytoplasm of adult Sertoli cells. Albumin and transferrin staining patterns paralleled each other during ontogenesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00306119
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  • 4
    Electronic Resource
    Electronic Resource
    Immunolocalization of albumin and transferrin in germ cells and Sertoli cells during rat gonadal morphogenesis and postnatal development of the testis (1994)
    Springer
    Cell & tissue research 276 (1994), S. 347-351 
    Details
    ISSN: 1432-0878
    Keywords: Key words: Albumin – Transferrin – Germ cells – Sertoli cells – Testis – Immunocytochemistry – Ontogenesis – Rat (Wistar)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract. The localization of albumin and transferrin was examined immunohistochemically in germ cells and Sertoli cells during rat gonadal morphogenesis and postnatal development of the testis. These proteins appeared as early as the 13th day of gestation in migrating primordial germ cells before Sertoli cell differentiation. In the fetal testis, strong immunoreactivity was only detected in the gonocytes. In the prepubertal testis, spermatogonia, primary spermatocytes, and some Sertoli cells accumulate albumin and transferrin. At puberty, different patterns of immunostaining of the germ cells were observed at the various stages of the cycle of the seminiferous epithelium. Diplotene spermatocytes at stage XIII, spermatocytes in division at stage XIV, and round spermatids at stages IV–VIII showed maximal staining. Labeling was evident in the cytoplasm of adult Sertoli cells. Albumin and transferrin staining patterns paralleled each other during ontogenesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00306119
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  • 5
    Electronic Resource
    Electronic Resource
    Anionic sites in the basement membrane of the rat epididymal epithelium during ontogenesis and after testicular and gonadal tract lesions (1987)
    Springer
    Cell & tissue research 250 (1987), S. 135-139 
    Details
    ISSN: 1432-0878
    Keywords: Epididymis ; Basement membrane ; Anionic sites ; Differentiation ; Androgen ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Anionic binding sites in the lamina densa of the basement membrane of the rat epididymal epithelium were demonstrated ultrastructurally with the use of cationized polyethyleneimine (PEI). Enzyme digestion with heparitinase removed the anionic sites, indicating that they consist largely of heparan sulfates. The anionic sites are present as early as the 16th day of gestation on the interstitial face of the lamina densa; later during gestation they are localized on both faces of the lamina densa without further modification after birth. The distribution of the anionic sites was identical all along the epididymal duct. After castration and ligation of efferent ducts or in the state of cryptorchidism the sites were more numerous and located inside the thicker portion of the lamina densa. These alterations were more prominent in the initial segment compared to the distal segments, suggesting a differential androgen dependence of the reactive sites and their patterns of distribution.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00214664
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  • 6
    Electronic Resource
    Electronic Resource
    Diffusion of horseradish peroxidase perfused through the lateral ventricle of the chick telencephalon (1975)
    Springer
    Cell & tissue research 157 (1975), S. 535-540 
    Details
    ISSN: 1432-0878
    Keywords: Cerebral perivascular spaces ; Peroxidase ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Horseradish peroxidase, perfused into the lateral ventricle of chick brain, freely and slowly diffuses through the cerebral extracellular spaces. The layer of astrocytic end-feet surrounding blood capillaries does not constitute a barrier to the tracer which permeates the basal lamina, diffuses between the pericytic cells and finally accumulates in the intercellular space beneath the tight junctions between contiguous endothelial cells. No evidence was found for transport by micropinocytotic vesicles from the cerebral parenchyma to the capillary lumen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00222605
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  • 7
    Electronic Resource
    Electronic Resource
    Histoimmunological identification of a prolactin-like substance in rodent testis (1985)
    Springer
    Cell & tissue research 240 (1985), S. 663-667 
    Details
    ISSN: 1432-0878
    Keywords: PRL-like material ; Histoimmunology ; Testis ; Adenohypophysis ; Rat ; Mouse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Anti-rat prolactin (PRL) antibodies were localized by histoimmunological methods in the cytoplasm of testicular interstitial cells, Sertoli cells, spermatogonia and primary spermatocytes of the rat and mouse. Control of specificity by affinity chromatography methods showed this PRL-like material to be non-specific in these testicular tissues, but specific in adenohypophyseal cells. These results are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00216354
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  • 8
    Electronic Resource
    Electronic Resource
    An autoradiographic study on the biosynthesis of the capillary basal lamina in the chick embryo telencephalon (1978)
    Springer
    Cell & tissue research 192 (1978), S. 299-308 
    Details
    ISSN: 1432-0878
    Keywords: Basal lamina biosynthesis ; Telencephalic capillaries ; Chick embryos ; 3H-proline autoradiography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Description / Table of Contents: Résumé L'élaboration de la lame basale des capillaires télencéphaliques a été étudiée en autoradiographie chez des embryons de Poulet âgés de 16 à 19 jours d'incubation. C'est au cours de cette période du développement que la basale des vaisseaux cérébraux est activement synthétisée. Les animaux furent sacrifiés 2,15, 40 et 180 min après le début de l'injection intraveineuse d'une solution de proline tritiée. L'identification des cellules participant à la synthèse de la basale est facilitée par le fait que l'hydroxylation de la proline en hydroxyproline y est réalisée. Nos observations nous permettent de suggérer une participation active des cellules endothéliales, des péricytes, et peut-être des cellules gliales, à l'élaboration de la lame basale. Les différentes étapes de cette synthèse ont lieu, par ordre chronologique, dans l'ergastoplasme, puis dans l'appareil de Golgi, avant que le produit élaboré ne soit libéré dans l'espace périvasculaire par exocytose.
    Notes: Summary The elaboration of the basal lamina of telencephalic capillaries has been studied by autoradiography in chick embryos from day 16 to 19 of incubation. The cerebral vascular basal lamina is actively synthesized during the period of these stages of development. The animals were sacrificed 2, 15, 40 and 180 min after intravenous injection of 3H-proline. The hydroxylation of proline to hydroxyproline in the “secretory” cells permits their identification. Our observations suggest that endothelial cells, pericytes and perhaps glial cells participate in this elaboration. The various stages of the synthesis are performed sequentially in the ergastoplasm and then in the Golgi apparatus before the secretory material is released by exocytosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00220747
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