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  • 1
    Electronic Resource
    Electronic Resource
    The effect of nacom (L-dopa and L-carbidopa) on growth hormone secretion in 75 patients with short stature (1977)
    Springer
    European journal of pediatrics 127 (1977), S. 15-19 
    Details
    ISSN: 1432-1076
    Keywords: HGH secretion ; L-Dopa ; L-Carbidopa ; Arginine test
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The stimulatory effect of Nacom® (250 mg L-Dopa and 25 mg L-Carbidopa) on the HGH secretion was evaluated in 75 short stature patients. The number of blood samples was restricted to only three (0, 45 and 90 min). 63 patients reached adequate HGH concentrations after the ingestion of 1 tablet Nacom (84%). Somatotropin levels increased from 2.08 (S x 0.28) to a maximal HGH value of 14.22 (S x 0.87) ng/ml. When the stimulatory effect of Nacom was compared with the standard method of arginine infusion in children with normal stature the arginine test was not superior to the Nacom-test. The Nacom-test appears to be a simple and reliable screening method for HGH deficiency, particularly in outpatients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00465561
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  • 2
    Electronic Resource
    Electronic Resource
    Untersuchungen über die Sekretion des Wachstumshormons nach Gabe von Nacom (l-Dopa und l-Carbidopa) (1976)
    Springer
    European journal of pediatrics 122 (1976), S. 195-200 
    Details
    ISSN: 1432-1076
    Keywords: HGH secretion ; l-Dopa ; l-Carbidopa
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei Kindern ohne Minderwuchs im Alter von 6–14 Jahren wurde nach oraler Gabe von 250 mg Levodopa und 25 mg l-Carbidopa (Nacom, ein Kombinations-präparat) die Wachstumshormonkonzentration im Serum bestimmt. Alle Probanden zeigten einen ausreichenden Wachstumshormonanstieg. Der Mittelwert betrug 19,6 ng/ml. Nach dem Maximum der HGH-Konzentration ließen sich zwei Gruppen unterscheiden. Die eine Gruppe erreichte zum Zeitpunkt 20 bzw. 40 min, die andere nach 60 bzw. 90 min den stärksten HGH-Anstieg. Aufgrund des Verlaufs der Mittelwertskurve werden 2 Blutentnahmen, 40 und 90 min nach Einnahme des Präparates, zum Ausschluß eines Wachstumshormonmangels für ausreichend gehalten. Das wahrscheinlich zugrundeliegende Wirkungsprinzip der HGH-Sekretion durch l-Dopa und l-Carbidopa wird anhand der Literatur diskutiert.
    Notes: Abstract The stimulatory effect of l-Dopa and l-Carbidopa (Nacom) on HGH secretion was determined in 12 children of normal height aged from 6 to 14 years. Each child received a standard dose of 250 mg l-Dopa and 25 mg l-Carbidopa p.o. HGH concentration in the serum was determined at standard intervals. All subjects showed a sufficient increase of HGH. The mean value was 19.6 ng/ml. According to the maximum values of the HGH concentration the sample can be divided into two groups; the first group reached the highest values after 20–40 min, the second one after 60–90 min. On evaluation of the curve of the mean values it appears that 2 blood samples taken 40 and 90 min after the ingestion of l-Dopa and l-Carbidopa are sufficient in order to exclude HGH deficiency. The theoretical background for HGH secretion after stimulation by l-Dopa and l-Carbidopa is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00463737
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  • 3
    Electronic Resource
    Electronic Resource
    Transient hypothyroidism associated with prematurity, sepsis, and respiratory distress (1979)
    Springer
    European journal of pediatrics 132 (1979), S. 85-92 
    Details
    ISSN: 1432-1076
    Keywords: Transient hypothyroidism ; Neonatal intensive care ; Preterm infants ; Respiratory distress syndrome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Serial TSH and T4 determinations were performed in sixty neonates admitted to our hospital for neonatal intensive care within a period of three months. Seven patients (12%) showed transient hypothyroidism on the basis of low T4 and high TSH values. Only one of these patients, who had meconium aspiration and pneumonia, did not have the respiratory distress syndrome. In addition, 4 of these patients had sepsis. All of the patients were born before 37 gestational weeks and had birth weight under 2200 g. In addition, two patients of this gestational age and birth weight group had a progressive fall of T4 to extremely hypothyroid values without simultaneous elevation of TSH. Two of the 5 patients who died had histological studies of their thyroids. These revealed colloid-depleted vesicles, desquamated epithelium, and prominent vascularisation of the thyroid. The results of this study show that early recognition and therapy of transient hypothyroidism may be live saving.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00447374
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  • 4
    Electronic Resource
    Electronic Resource
    Über die Autoxydation von Norbornenderivaten (1975)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 317 (1975), S. 1027-1034 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: On the Autoxidation of Derivatives of NorbornenenNorbornene, bicyclo[2, 2, 1]2-heptene-5-carboxylic acid methyl ester, bicyclo-[2, 2, 1]2-heptene-5-carbonitril, 5-methylbicyclo[2, 2, 1]2-heptene-5-carboxylic acid methyl ester and dicyclopentadiene are easily oxidized by molecular oxygen; the corresponding exo-epoxides are formed as main products by attack on the norbornene double bond.
    Notes: Norbornen, Bicyclo[2, 2, 1]hepten-(2)-carbonsäure-(5)-methylester, Bicyclo[2, 2, 1]hepten-(2)-carbonsäure-(5)-nitril, 5-Methylbicyclo[2, 2, 1]hepten-(2)-carbonsäure-(5)-methylester und Dicyclopentadien werden von molekularem Sauerstoff leicht oxydiert; als Hauptprodukte bilden sich unter Angriff auf die Norbornendoppelbildung die entsprechenden exo-Epoxide.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19753170619
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    Paper (German National Licenses)
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