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  • 1
    ISSN: 1432-0428
    Keywords: Pancreatic islets ; insulin secretion ; insulin content ; glucagon secretion ; glucagon content ; wistar rats ; sand rats ; glucose ; arginine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Isolated pancreatic islets of normoglycemic sand rats do not respond to 2.5 mM glucose with an enhanced glucagon secretion, which could be observed in normal Wistar rats. Arginine stimulates glucagon release in the presence of 2.5 mM glucose in Wistar rats as well as in sand rats. The secretion pattern is not caused by insulin deficiency since sand rat islets are characterized by an increased insulin secretion rate in vitro. This paradoxical glucagon secretion is not caused by a changed glucagon content but might be related to this species which is able to develop a diabetic syndrome spontaneously.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Research in experimental medicine 165 (1975), S. 111-125 
    ISSN: 1433-8580
    Keywords: Bencyclan-isolated atria-anaesthetized cat-contractility ; bloodpressure ; Bencyclan ; isolierter Vorhof ; narkotisierte Katze ; Kontraktilität ; Blutdruck
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Am isolierten Meerschweinchenvorhof sowie an narkotisierten Katzen und Hunden wurde die Wirkung des Bencyclans auf Herz und Blutdruck untersucht. Es fanden sich folgende Ergebnisse: 1.) Bencyclan senkt dosisabhängig Kontraktionskraft, maximale Kontraktionsgeschwindigkeit und die Kontraktionsfrequenz am Meerschweinchenvorhof; dabei wird die funktionelle Refraktärzeit verlängert. 2.) Die negativ inotrope Wirkung des Bencyclans ist am Meerschweinchenvorhof durch Steigerung der Ca++-Konzentration aufhebbar. 3.) Bei gleichzeitiger Bencyclaneinwirkung bleibt die Orciprenalinwirkung am linken Vorhof unbeeinflußt, während die Serotoninwirkung abgeschwächt ist. 4.) 5mg/kg Bencyclan bewirken an der narkotisierten Katze einen signifikanten Abfall von Blutdruck und Kontraktilität des Herzens. Während der Blutdruck innerhalb weniger Minuten wieder den Vorwert erreicht, hält die Kontraktilitätsminderung länger an. 5.) 2 von 10 Katzen und 2 von 3 Hunden starben innerhalb weniger Minuten nachdem 5 mg/kg Bencyclan und 1 mg/kg Propranolol im Abstand von 15 min. injiziert wurden. 6.) Eine Vorbehandlung mit 20 mg/kg Propranolol i.m. steigert bei Mäusen die akute i.v.-Bencyclantoxizität nicht signifikant.
    Notes: Summary In the isolated guinea pigs atria as well as in anaesthetized cats and dogs we studied the cardiovascular effects of bencyclan. The following results were found: 1.) Bencyclan causes a dose-dependent diminution of the force of contraction, the maximal rate of rise of contraction, and the frequency of the isolated atria, while the functional refractory period is prolonged. 2.) The negative inotropic effect of bencyclan can be antagonized in the isolated atria by increasing Ca++-concentrations. 3.) In the isolated left atria the effect of orciprenaline is unchanged while the effect of serotonin is diminished by bencyclan. 4.) In the anaesthetized cat 5 mg/kg of bencyclan cause a significant decrease of blood-pressure and contractility. While the fall of blood-pressure is reversed within a few minutes, the contractility is diminished for a longer time. 5.) 2 of 10 cats and 2 of 3 dogs died within a few minutes when 5 mg/kg bencyclan and 1 mg/kg propranolol were injected within an interval of 15 minutes. 6.) Pretreatment with 20 mg/kg propranolol i.m. does not increase the acute toxicity of bencyclan in mice significantly.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 437 (1977), S. 210-212 
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Contributions to the Chemistry of Transition Metal Alkyl Compounds. XXV. Preparation and Properties of [Ti(CH2CN)4 · 2 THF]nTetracyanomethyl titanium, [Ti(CH2CN)4 · 2 THF]n, can be prepared by reaction of TiCl4 with LiCH2CN in form of a tetrahydrofuran complex. The brown, stable compound, which seems to be a coordination polymer, was characterized by i.r. and 1H-n.m.r. spectra.
    Notes: Tetracyanmethyltitan läßt sich durch Reaktion von Titan(IV)-chlorid mit Cyanmethyllithium als braune, thermisch recht beständige, offensichtlich koordinationspolymere Verbindung der Formel [Ti(CH2CN)4 · 2 THF]n gewinnen. Eine nähere Charakterisierung erfolgte mittels des IR- und des 1H-NMR-Spektrums.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 435 (1977), S. 45-48 
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Contributions to the Chemistry of Transition Metal Alkyl Compounds. XXIV. Preparation and Properties of Tetrabenzyl Molybdenum and Tetrabenzyl UraniumTetrabenzyl molybdenum, (C6H5CH2)4Mo, can be obtained by the reaction of MoCl4 · 2 THF with dibenzyl magnesium. The compound forms darkbrown crystals, which are stable at room temperature. The analogous reaction of UCl4 · 3 THF with dibenzyl magnesium yields a reddish brown complex of tetrabenzyl uranium of the formula (C6H5CH2)4U · MgCl2. The synthesized compounds are characterized more in detail.
    Notes: Tetrabenzylmolybdän, (C6H5CH2)4Mo, läßt sich durch Umsetzung von Molybdän(IV)-chlorid-bis(tetrahydrofuran) mit Dibenzylmagnesium in Form schwarzbrauner, bei Zimmertemperatur beständiger Kristalle gewinnen. Bei der analogen Reaktion von Uran(IV)-chlorid-tris(tetrahydrofuran) mit Dibenzylmagnesium entsteht ein rotbrauner Tetrabenzyluran-Komplex der Formel (C6H5CH2)4U · MgCl2.  -  Beide Verbindungen werden näher charakterisiert.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 421 (1976), S. 129-134 
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Contributions to the Chemistry of Transition Metal Alkyl Compounds. XVIII. On the Preparation and Properties of Tetrabenzyl Vanadium and Benzyl Tantalum ChloridesPure tetrabenzyl vanadium was isolated and characterized by elementary analyses, EPR and 1H-NMR spectra, by hydrolysis and thermal decomposition.  -  Experiments for the preparation of tetra or pentabenzyl compounds of niobium and tantalum failed, but we could prepare C6H5CH2TaCl4, (C6H5CH2)2TaCl3, and (C6H5CH2)3TaCl2, the last two in form of bipyridyl complexes.
    Notes: Vanadintetrabenzyl wurde in definierter Form isoliert und durch Elementaranalyse, ESR- und 1H-NMR-Spektrum sowie durch die hydrolytische und thermische Spaltung charakterisiert.  -  Versuche zur Gewinnung von Tetra- und Pentabenzylverbindungen des Niobs und Tantals blieben erfolglos. Es gelang jedoch, die Verbindungen C6H5CH2—TaCl4, (C6H5CH2)2TaCl3 und (C6H5CH2)3TaCl2, zum Teil in Form von Dipyridylkomplexen, zu gewinnen.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
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