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  • 1
    Electronic Resource
    Electronic Resource
    The comparative bioavailability of Lanoxin tablets and Lanoxicaps with and without sorbitol (1978)
    Springer
    European journal of clinical pharmacology 14 (1978), S. 357-360 
    Details
    ISSN: 1432-1041
    Keywords: Lanoxin tablets ; Lanoxicaps ; sorbitol ; bioavailability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary (1) The mean cumulative urinary digoxin excretion over 8 days was compared in 8 healthy volunteers after single doses of digoxin administered as 3 Lanoxin tablets of 0.25 mg, 3 digoxin tablets of 0.2 mg, 12 Lanoxicaps without sorbitol of 0.05 mg, 6 Lanoxicaps without sorbitol of 0.1 mg digoxin, 3 Lanoxicaps without sorbitol of 0.2 mg and 3 Lanoxicaps with sorbitol of 0.2 mg. (2) There was no significant difference between the 8 day cumulative urinary excretion for any of the Lanoxicaps treatments. (3) Cumulative urinary excretion after 3 digoxin tablets of 0.2 mg was significantly (P〈0.05) lower than after all other treatments. (4) Cumulative urinary excretion after 3 Lanoxin tablets of 0.25 mg was not significantly different from that after any of the Lanoxicaps treatments except 0.1 mg Lanoxicaps without sorbitol, it was significantly (P〈0.05) lower after the latter. (5) Mean urinary excretion of digoxin was 60% of ingested dose for all Lanoxicaps treatments and was significantly (P〈0.05) higher than the mean value of 50% for both tablet treatments. (6) Enhanced absorption of digoxin from Lanoxicaps was confirmed and shown to be unrelated to the sorbitol content of the capsule shell.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00611906
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Effects of propranolol and oxprenolol on the vasoconstrictor response to noradrenaline in the superficial hand vein in man (1978)
    Springer
    European journal of clinical pharmacology 14 (1978), S. 83-85 
    Details
    ISSN: 1432-1041
    Keywords: Propranolol ; oxprenolol ; noradrenalineduced vasoconstriction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effects of oxprenolol and propranolol on the venoconstrictor response to noradrenaline were studied in healthy volunteers by measuring superficial dorsal hand vein diameter at a standard congesting pressure. In 8 subjects dose response curves to noradrenaline (20–1280 ng/ml) were obtained with noradrenaline alone, with noradrenaline plus propranolol 10 µg/ml, with noradrenaline plus propranolol 10 µg/ml plus oxprenolol 3 µg/ml and with noradrenaline plus propranolol 13 µg/ml according to a double blind balanced randomised design. Propranolol 10 µg/ml significantly (P〈0.05) potentiated the vasoconstrictor response to noradrenaline and the addition of oxprenolol significantly (P〈0.05) reversed the potentiation giving a response similar to that seen with noradrenaline alone. The higher concentration of propranolol did not produce further potentiation, the response being similar to that obtained with the lower concentration of propranolol. It is suggested that the effect of oxprenolol may be attributable to alpha blocking properties, to partial beta agonism or to its membrane stabilising properties.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00607435
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Erratum (1979)
    Springer
    European journal of clinical pharmacology 15 (1979), S. 72-72 
    Details
    ISSN: 1432-1041
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00563561
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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