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  • 1
    Electronic Resource
    Electronic Resource
    THE EFFECT OF CHORIONIC GONADOTROPHIN AND CHORIONIC SOMATOMAMMOTROPHIN ON STEROIDOGENESIS IN THE CORPUS LUTEUM (1971)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 78 (1971), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Human chorionic gonadotrophin was given every other day to 8 women during 11 luteal phases and their excretion of oestrone and pregnanediol compared with the excretion of these steroids during an untreated luteal phase. Some of these subjects were also given chorionic somatomammotrophin while being treated with chorionic gonadotrophin. It was found that treatment with chorionic gonadotrophin resulted in an increase of ovarian hormone excretion and that the steroid levels remained elevated while the onset of menstruation was postponed. A decline in steroid excretion and menstruation eventually occurred in spite of continued treatment with chorionic gonadotrophin. There was no evidence that the administration of chorionic somatomammotrophin had any effect on ovarian steroidogenesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1971.tb00314.x
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  • 2
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    The Scientific Heritage (Book Review) (1973)
    Chicago, Ill. : Periodicals Archive Online (PAO)
    Modern Age. 17:4 (1973:Fall) 439 
    Details
    ISSN: 0026-7457
    Topics: Political Science
    Notes: Reviews
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:5195-1973-017-04-000019
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  • 3
    Electronic Resource
    Electronic Resource
    Photoproton spectrum from carbon with good energy resolution (1974)
    Springer
    The European physical journal 270 (1974), S. 93-95 
    Details
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The 90° photoproton spectrum from12C has been measured with good energy resolution using bremsstrahlung with maximum energyEγ=31 MeV. A fragmentation of the giant dipole resonance in fine structures with a typical width of 150 to 300 keV is observed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01677439
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  • 4
    Electronic Resource
    Electronic Resource
    Properties of high-energy pions emitted from heavy-ion collisions at 1 GeV/nucleon (1995)
    Springer
    The European physical journal 352 (1995), S. 175-179 
    Details
    ISSN: 1434-601X
    Keywords: 25.75.+r
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Positively charged pions and protons from collisions of Ne+NaF and Au+Au at 1 GeV/nucleon incident energy were measured near midrapidity. The center-of-mass pion spectra deviate from a Maxwell-Boltzmann distribution. The slope of the high-energy part of the pion spectra varies significantly with the system mass and little with the size of the reaction zone. While the total pion yield rises linearly with the number of participant nucleons, the highenergy component increases more than linearly.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01298905
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  • 5
    Electronic Resource
    Electronic Resource
    Influence of therapeutic and toxic doses of neuroleptics and antidepressants on energy metabolism of the isolated perfused rat brain (1973)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 279 (1973), S. 243-254 
    Details
    ISSN: 1432-1912
    Keywords: Neuroleptics ; Antidepressants ; Isolated Perfused Rat Brain ; High Energy Phosphates ; Glycolytic Pathway
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The isolated perfused rat brain was used for a comparative study of the effects of promazine, imipramine, monodesmethyl promazine and desipramine on cerebral energy metabolism. After perfusion for 30 min or 1 h the brain levels of the following substrates and metabolites were estimated: P-creatine, creatine, ATP, ADP, AMP, glycogen, glucose, glucose-6-P, fructose diphosphate, dihydroxyacetone-P, pyruvate, lactate, α-ketoglutarate, and ammonia. Drug concentrations of 5·10−6 M and 10−5 M in the perfusion medium caused a significant decrease of glucose-6-P alone. When the drug concentration was raised to a toxic range (10−4 M), reflected in the EEG by the pattern of secondary discharges, an accumulation of P-creatine and glucose and a decrease of glycogen, glucose-6-P and ammonia occurred; the lactate/pyruvate ratios remained unchanged. As there were no qualitative differences between the effects of the investigated neuroleptics and antidepressants on cerebral metabolism, these effects might be unspecific and not correlated with the pharmacological action of the drugs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00500604
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  • 6
    Electronic Resource
    Electronic Resource
    Comparative study of the effects of chloral hydrate and trichloroethanol on cerebral metabolism (1973)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 277 (1973), S. 323-332 
    Details
    ISSN: 1432-1912
    Keywords: Chloral Hydrate ; Trichloroethanol ; Isolated Perfused Rat Brain ; High-Energy Phosphates ; Glycolytic Pathway
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The isolated perfused rat brain was used for a comparative study of the effects of chloral hydrate and trichloroethanol on cerebral energy metabolism. After a perfusion period of 30 min the brain levels of the following substrates and metabolites were measured spectrophotometrically: P-creatine, creatine, ATP, ADP, AMP, glycogen, glucose, glucose-6-P, fructose diphosphate, α-glycero-P, dihydroxyacetone-P, pyruvate, lactate, glutamate, α-ketoglutarate and ammonia. Furthermore, the concentration of chloral hydrate and trichloroethanol in the isolated brain and in the perfusion medium was measured colorimetrically. Little more than 10% of chloral hydrate in the isolated brain and in the perfusion medium were reduced to trichloroethanol. In intact animals there were about 70% of chloral hydrate transformed. Chloral hydrate and trichloroethanol caused an accumulation of P-creatine, no change in the lactate/pyruvate ratio, an increase of the glucose concentration and a decrease of glucose-6-P level in the isolated brain. The rise of brain glucose level was more pronounced after trichloroethanol than after chloral hydrate. The effects of chloral hydrate and trichloroethanol on brain glucose and glucose-6-P levels suggest an inhibition of brain hexokinase activity by these drugs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00500993
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  • 7
    Electronic Resource
    Electronic Resource
    p53 gene mutations and expression of p53 and mdm2 proteins in invasive breast carcinoma (1997)
    Springer
    Journal of cancer research and clinical oncology 123 (1997), S. 388-394 
    Details
    ISSN: 1432-1335
    Keywords: Key words p53 ; mdm2 ; p53 gene mutation ; Breast carcinoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The aim of the study was to analyze p53 gene mutations and the expression of p53 and mdm2 proteins in 31 randomly selected invasive breast carcinomas. The results were then correlated with tumor grade, stage, estrogen receptor status, nodal status, and DNA ploidy. The expression of the proteins p53 and mdm2 was determined immunohistochemically using formalin-fixed, paraffin-embedded material. Screening for p53 mutation involved analysis of the highly conserved regions of the p53 gene (exons 5–9) by the polymerase chain reaction/single-strand conformation polymorphism (PCR-SSCP) technique. PCR products with band shifts were directly sequenced. Immunohistochemical staining of p53 was positive in 9 cases (29.0 %), only 2 of which showed a p53 gene mutation. These were identified as a C→G transversion at the second position of codon 278 in exon 8 and an A→G transition at the second position of codon 205 in exon 6. A third case with a mutation was observed (C→T transition, position 1 of codon 250 in exon 7) that did not show p53 immunohistochemically. Of the 9 p53-positive tumors, 2 were moderately differentiated (grade II). The remaining tumors were poorly differentiated (7/9). By contrast, p53-negative carcinomas were well differentiated (grade I) in most cases (P = 0.02). DNA cytometry in 8 of the 9 p53-positive carcinomas revealed an aneuploid stem line. The majority of the p53-negative tumors were diploid (P = 0.01). Mdm2 oncoprotein was detected in 10 tumors (32.2 %), 4 of which were p53-positive, including the 3 with mutations. The grading of the mdm2-positive tumors was moderate or poor, G1 carcinomas were always noted to be mdm2-negative (P = 0.04). Overexpression of p53 protein is a complex mechanism and does not merely indicate the detection of mutations in the p53 gene. This study has shown that p53 expression correlates with tumor grade and DNA ploidy. Mdm2 expression was also associated with the tumor grade. Immunohistological demonstration of the p53 protein alone is insufficient as a basis for comment on the functional state of the p53 gene and gene product. The interrelation between recognition of the p53 protein and gene mutation needs more careful assessment to define their roles in the control of neoplasia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01240122
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  • 8
    Electronic Resource
    Electronic Resource
    Age estimation in biopsy specimens of dentin (1995)
    Springer
    International journal of legal medicine 108 (1995), S. 135-139 
    Details
    ISSN: 1437-1596
    Keywords: Age determination ; Living persons Aspartic acid racemization ; Dentin ; Dentinal biopsy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Notes: Abstract Determination of age at death on the basis of aspartic acid racemization in dentin is one of the most reproducible and accurate methods. In Germany, age estimation by this method has so far generally not been applied to living persons, since the extraction of a tooth exclusively for age estimation when it is not medically indicated is regarded as ethically and legally problematic. The development of a biopsy technique applicable to dentin took place against this background. Testing the technique and analysis of dentinal biopsy specimens revealed that the biopsy technique is a low-risk procedure that causes only minor discomfort to the affected person. It is readily practicable and facilitates standardized specimen removal. The relationship between the extent of aspartic acid racemization in dentinal biopsy specimens and age is very close, facilitating age estimation. A prerequisite for accurate results is the performance of biopsies under strictly standardized conditions. If this is guaranteed, age determination on the basis of aspartic acid racemization in dentinal biopsy specimens appears to be superior in precision to most other methods in living persons and can be used for all age groups.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01844824
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  • 9
    Electronic Resource
    Electronic Resource
    No correlation of c-myc overexpression and p53 mutations in liposarcomas (1998)
    Springer
    Virchows Archiv 433 (1998), S. 315-321 
    Details
    ISSN: 1432-2307
    Keywords: Key words Liposarcoma ; c-myc gene expression ; p53 gene mutations
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Although it is well known that oncogenesis is a multistep process involving the activation of normal cellular genes to become oncogenes and/or the inactivation of tumor suppressor genes, this process has seldom been investigated in soft tissue tumours. We screened a group of 36 liposarcomas for genetic abnormalitis in the p53 tumour suppressor gene and c-myc oncogene. Altered c-myc gene expression was examined by differential RT-PCR assay. p53 Gene mutations in exons 4–8 were analysed by using PCR-SSCP analysis and direct sequencing. Elevated c-myc expression was found in 6 of 31 liposarcomas (19.4%). p53 Gene mutations were observed in 5 of 36 liposarcomas (13.9%). Both genetic alterations were associated with the histological subtype of liposarcomas. Whereas c-myc gene expression was a characteristic of myxoid/round cell liposarcomas, p53 gene mutations were found more frequently in pleomorphic variants. Liposarcomas of the well-differentiated subtype showed neither p53 gene mutations nor altered c-myc gene expression. Our results indicate that the c-myc oncogene and the p53 tumor suppressor gene do not seem to cooperate in the oncogenesis of liposarcomas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004280050255
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  • 10
    Electronic Resource
    Electronic Resource
    The isolated perfused rat brain as a model for studying drugs acting on the CNS (1974)
    Springer
    Psychopharmacology 35 (1974), S. 169-177 
    Details
    ISSN: 1432-2072
    Keywords: Isolated Rat Brain ; Methods ; Perfusion ; Cerebral Metabolism ; Animal EEG
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract An isolated perfused brain preparation is regarded as offering some important advantages over intact animals or tissue slices for studying drug effects on the CNS. The rat is by far the most suitable laboratory animal for this technique because of low cost, ease of preparation and extensive literature available for comparative purposes. In this paper various preparation techniques and perfusion systems for an isolated rat brain are reported. Investigations are presented proving the viability of the isolated perfused rat brain for more than seven hours and its suitability for studies on cerebral metabolism. Until now this preparation has been successfully used for pharmacological investigations concerning the drug effects on cerebral energy metabolism, on the EEG and on the biogenic amines in the CNS. The results further demonstrate that the use of an isolated perfused rat brain affords the possibility of clarifying pharmacological problems which has not been possible using conventional methods. In addition, this preparation should become a very useful tool for studies on pharmacokinetics, on brain circulation or on brain oxygen consumption.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00429583
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