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  • 1
    Electronic Resource
    Electronic Resource
    "Quantamycin" - a computer-simulated new-generation inhibitor of bacterial ribosomal binding (1984)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 106 (1984), S. 6114-6115 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja00332a078
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  • 2
    Electronic Resource
    Electronic Resource
    Preparation of a number of 5-butylpyrimidine nucleosides (1972)
    s.l. : American Chemical Society
    Journal of medicinal chemistry 15 (1972), S. 1061-1065 
    Details
    ISSN: 1520-4804
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jm00280a016
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  • 3
    Electronic Resource
    Electronic Resource
    Changes in Natural Killer Activities in Experimental Secondary Amyloidosis (1984)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 19 (1984), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Natural killer (NK) cell aciiviiy in experimental murine amyloidosis was studied. In CBA/J mice, which show a high incidence of amyloidosis. NK activity was significantly decreased after 1 week of casein treatment. In C3H mice, which show a low incidence of amyloidosis, NK activity was not changed by casein treatment. Pretreatment with lipopolysaccharide in vivo enhanced the NK activities in CBA/J and C3H mice. These increases were not observed after casein treatment. The lowered NK activity of cells from CBA/J mice after casein treatment was restored to the normal range by indomethacine in vitro. Depletion of adherent cells from the spleen cells treated with casein had no effect on NK activity. Single-cell assay showed that casein treatment impaired the killing but not the binding of NK cells to target cells. After casein treatment, the splenic serum amyloid A (SAA) level gradually increased in CBA/J mice but remained low in C3H mice. NK activity was suppressed by the addition of serum obtained from CBA/J mice treated with casein but not by normal control serum. And partially purified AA protein obtained from the spleen of CBA/J mice treated with casein also suppressed NK activity in vitro.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1984.tb00962.x
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  • 4
    Electronic Resource
    Electronic Resource
    Plasma levels of antidiuretic hormone in man during methoxyflurane anaesthesia and surgery (1970)
    Oxford, UK : Blackwell Publishing Ltd
    Anaesthesia 25 (1970), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2044.1970.tb00256.x
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  • 5
    Electronic Resource
    Electronic Resource
    Inhibition of N-Nitrosamine Formation in a Cured Ground Pork Belly Model System (1984)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food science 49 (1984), S. 0 
    Details
    ISSN: 1750-3841
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Notes: A model system consisting of a uniformly distributed sample of ground pork in conjunction with a nitrite containing curing solution was utilized to evaluate the formation of N-nitrosamines. Utilizing this system a wide variety of compounds were discovered to dramatically reduce the level of N-nitrosopyrrolidine (NPyr) formed during frying. Carbohydrates including the reducing sugars dextrose, ribose, lactose, and maltose, as well as liquid smoke preparations, were found to reduce NPyr levels by as much as 60%. In addition, when low levels of combinations of inhibitors glucose, liquid smoke, and α-tocopherol were incorporated, reductions in nitrosamine levels as great as 80% were observed in model systems as well as in pilot plant manufactured bacon.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2621.1984.tb12417.x
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  • 6
    Electronic Resource
    Electronic Resource
    Model System Studies on N-Nitrosamine Formation in Cured Meats: The Effect of Curing Solution Ingredients (1981)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food science 46 (1981), S. 0 
    Details
    ISSN: 1750-3841
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Solutes commonly employed in curing solutions were evaluated for their effect on nitrosamine formation utilizing a ground pork model system. Sodium erythorbate and sodium ascorbate were found to be equally effective in reducing nitrosopyrrolidine levels. The incorporation of sodium tripolyphosphate or sucrose had no detectable effect on nitrosamine formation. However, sodium chloride, the solute present at the highest concentration in bacon curing solutions, exhibited a concentration dependent inhibition of nitrosopyrrolidine formation. Nitrosopyrrolidine levels in samples containing no added sodium chloride were found to be 50% higher than samples processed with 1.5% added salt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2621.1981.tb02975.x
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  • 7
    Electronic Resource
    Electronic Resource
    Model System Studies on N-Nitrosamine Formation in Cured Meats: The Effect of Slice Thickness (1981)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food science 46 (1981), S. 0 
    Details
    ISSN: 1750-3841
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Notes: A model bacon system has been developed which enables a more reproducible determination of N-nitrosamines when compared to conventional methods of bacon production. Utilizing this system, the effect of slice thickness and frying time on nitrosopyrrolidine (NPyr) formation has been demonstrated. Short frying periods (3 min/side) result in higher NPyr levels for thinner sliced samples and longer frying periods (5 min/side) result in higher NPyr levels for thicker sliced samples. The level of N-nitrosamine formed is integrally related to slice thickness and frying time and may be explained when two factors are considered, the rate of N-nitrosamine formation and the rate of its volatilization.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2621.1981.tb15326.x
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  • 8
    Electronic Resource
    Electronic Resource
    MOLECULAR FORMS OF GLUTATHIONE S-TRANSFERASE AND UDP-GLUCURONYLTRANSFERASE AS HEPATIC PRENEOPLASTIC MARKER ENZYMES (1983)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 417 (1983), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1983.tb32865.x
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  • 9
    Electronic Resource
    Electronic Resource
    Electrophysiological analysis of bicarbonate permeation across the peritubular cell membrane of rat kidney proximal tubule (1984)
    Springer
    Pflügers Archiv 401 (1984), S. 34-42 
    Details
    ISSN: 1432-2013
    Keywords: Basolateral HCO 3 − transport ; pH ; $$p_{{\text{CO}}_{\text{2}} } $$ ; Carbonic anhydrase ; Anion substitution
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The membrane potential response of proximal tubular cells to changing HCO 3 − concentrations was measured in micro-puncture experiments on rat kidney in vivo. No significant effect was noticed when luminal bicarbonate concentration was changed. Changing peritubular HCO 3 − by substitution with Cl− resulted in conspicuous membrane potential transients, which reached peak values after 100–200 ms and decayed towards near control with time constants of ∼2s. The polarity of the potential changes and the dependence of the initial potential deflections on the logarithm of HCO 3 − concentration suggest a high conductance of the peritubular cell membrane for HCO 3 − buffer, but not for Cl−, SO 4 2− , or isethionate. At constant pH $$t_{{\text{HCO}}_{\text{3}}^ - } $$ was estimated to amount to ∼0.68. At constant $$p_{{\text{CO}}_{\text{2}} } $$ , $$t_{{\text{HCO}}_{\text{3}}^ - } $$ was even greater because of an additional effect of OH− or respectively H+ gradients across the cell membrane. The secondary repolarization may be explained by passive net movements of K+ and HCO 3 − across the peritubular cell membrane, which result in a readjustment of intracellular HCO 3 − to the altered peritubular HCO 3 − concentration. Application of carbonic anhydrase inhibitors in the tubular lumen reduced the initial potential response by one half and doubled the repolarization time constant. The same effect occurred instantaneously when the inhibitor was applied—together with the HCO 3 − concentration step—in the peritubular perfusate. This observation demonstrates that membrane bound carbonic anhydrase is somehow involved in passive rheogenic bicarbonate transfer across the peritubular cell membrane, and suggests that HCO 3 − permeation might occur in form of CO2 and OH− (or H+ in opposite direction).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00581530
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  • 10
    Electronic Resource
    Electronic Resource
    The effect of ischemia on sensorimotor cortex of cat (1970)
    Springer
    Journal of neurology 198 (1970), S. 33-45 
    Details
    ISSN: 1432-1459
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Complete cerebral ischemia was produced in normothermic cats by clamping the innominate and subclavian arteries and simultaneous lowering of the systemic blood pressure. The effect of ischemia on the sensorimotor cortex was assessed by neurophysiological, electronmicroscopical, and biochemical observations. Nerve cell excitability, synaptic transmission and EEG activity recovered after ischemia of up to 1 hr. The neurophysiological recovery was paralleled by the restoration of the energy-producing metabolism which approached normal values when spontaneous EEG activity reappeared. Electronmicroscopy revealed the structural preservation of the cortex after the recovery of function.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00316134
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