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  • 1
    Electronic Resource
    Electronic Resource
    Devices for Graident Elution in Chromatography (1954)
    s.l. : American Chemical Society
    Analytical chemistry 26 (1954), S. 1543-1546 
    Details
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ac60094a004
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  • 2
    Electronic Resource
    Electronic Resource
    Morphometrische Untersuchungen zum histologischen Nachweis des Corticotropin-Releasing Factor im Infundibulum der Ratte (1972)
    Springer
    Anatomy and embryology 137 (1972), S. 1-29 
    Details
    ISSN: 1432-0568
    Keywords: Corticotropin-Releasing Factor ; Median eminence ; Rat ; Histology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In der Zona externa infundibuli der normalen Ratte kommen geringe Mengen „Gomori-positiver” Granula vor. Nach bilateraler Adrenalektomie erfolgt eine Vermehrung der Granula, die sich durch Gabe von Hydrocortison einschränken oder verhindern läßt. Dieser Befund hat zu der Annahme geführt, daß die Granula das morphologische Äquivalent des Corticotropin-releasing factor (CRF) darstellen. Morphometrische Untersuchungen an 160 weiblichen Wistarratten zeigen, daß die Menge der nach bilateraler Adrenalektomie in der Zona externa infundibuli nachweisbaren „Gomori-positive” Granula von der postoperative Überlebensdauer abhängt. Die Granulamenge nimmt zunächst bis zum 14. Tag p.o. zu und fällt dann wieder ab. Substitution bilateral adrenalektomierter Ratten mit Hydrocortisonacetat-Kristallsuspension bewirkt eine dosisabhängige Verminderung der Granulamenge, wenn die Behandlung am Operationstag begonnen wird. Applikation von Hydrocortisonacetat-Kristallsuspension vom 14.–21. Tag p.o. führt dagegen zu einer gesteigerten Granulavermehrung. Auch bei stärkster Vermehrung sind die Granula stets nur im Infundibulum und nicht in anderen Bereichen des Hypothalamus nachweisbar. Sie besitzen bei bilateral adrenalektomierten Tieren ein charakteristisches Verteilungsmuster mit besonders hohen Konzentrationen in den paramedianen Abschnitten des rostralen Infundibulumdrittels. Aus der Art und Weise ihrer Verteilung ist zu vermuten, daß die Granula 2 Nervenfaserzügen angehören und ein Neurosekret darstellen. Nach den vorliegenden Untersuchungen besteht zwischen dem Verhalten der „Gomori-positiven” Granula in der Zona externa infundibuli und dem aus pharmakologischen Untersuchungen bekannten Verhalten des Corticotropin-releasing factor eine weitgehende Parallelität. Sie legt nahe, die Menge der Granula als Parameter der CRF-Aktivität zu verwenden.
    Notes: Summary In the zona externa infundibuli (outer layer of the median eminence) of the normal rat a minute number of “Gomori-positive” granules can be detected. Following bilateral adrenalectomy their number increases. This augmentation can be restricted or inhibited by administration of hydrocortisone, a finding, which has led to the assumption that the granules are the morphological equivalent of the corticotropin-releasing factor (CRF). Morphometrical studies on 160 female Wistar rats show that following bilateral adrenalectomy the quantity of “Gomori-positive” granules is dependent on the length of the post-operative survival period. Up to the 14th day p.o. the quantity of granules increases; from then on it diminishes. Substitution of bilaterally adrenalectomized rats with hydrocortisone acetate crystal suspension results in a dose-dependent decrease in the quantity of granules if treatment is begun on the day of operation. In contrast, administration of hydrocortisone acetate crystal suspension from the 14th to the 21st day p.o. results in increased augmentation of the granules. Even when maximum augmentation of the granules is reached, they are invariably found only in the infundibulum and not in other regions of the hypothalamus. In animals that have been subjected to bilateral adrenalectomy, the granules show a characteristic pattern of distribution, with particularly high concentrations in the paramedian parts of the rostral third of the infundibulum. The manner in which the granules are distributed suggests that they are a neurosecretory substance localized in two fibre tracts. The present study points to a close parallelism between the behaviour of the “Gomori-positive” granules in the zona externa infundibuli and that of the corticotropin-releasing factor as revealed by pharmacological investigations. It would seem that the quantity of granules can be used as a parameter of CRF activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00523528
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  • 3
    Electronic Resource
    Electronic Resource
    Influence of pantothenic acid deficiency on the amount of CRF-granules in the rat median eminence (1974)
    Springer
    Anatomy and embryology 146 (1974), S. 43-55 
    Details
    ISSN: 1432-0568
    Keywords: Pantothenic acid deficiency ; Corticotropin-releasing factor ; Corticoids ; Histologie ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In the outer layer of the rat median eminence “Gomori-positive” granules occur which are assumed to be the morphological correlate of the corticotropin-releasing factor (CRF). The present study was carried out in order to establish whether the amount of these CRF-granules is influenced by a pantothenic acid (PA)-deficiency, which is known to result in an inhibition of corticosteroid production. Female SPF Wistar rats were used. PA-deficiency was induced by PA-free nutrition and/or administration of the PA-antagonist Ω-methyl-PA. Corresponding experimental groups were given either tap water or a solution of 1% NaCl and 5% glucose in tap water to drink. In rats fed with a diet free of PA and in addition treated with Ω-methyl-PA a severe disturbance of the corticoid balance developed within 6 weeks. The corticosterone production was depressed to about 11–16% of the control values. The adrenal cortex showed necrotic changes which either involved the whole parenchyma or were confined to the inner zones. In those animals in which a subcapsular region, in its extent corresponding to the zona glomerulosa, remained intact, an augmentation of the CRF-granules was observed. In those animals, however, in which the whole adrenal cortex was damaged, the amount of CRF-granules did not increase. Administration of the 1% NaCl containing drinking fluid did not influence the augmentation of the CRF granules, but had a protective effect on the development of necrotic changes in the zona glomerulosa of the adrenal cortex. The findings show that a functional relationship exists between the inner zones of the adrenal cortex and the CRF-granules in the median eminence.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00341382
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  • 4
    Electronic Resource
    Electronic Resource
    Die Bildung von Spuren von Kohlenmonoxid durch Saccharomyces cerevisiae und andere Mikroorganismen (1974)
    Springer
    Archives of microbiology 100 (1974), S. 243-252 
    Details
    ISSN: 1432-072X
    Keywords: Saccharomyces cerevisiae ; Carbon Monoxide Trace-Measurement ; 14C-Glucose ; CO Production ; Atmospheric Cycle of Trace Gases
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Description / Table of Contents: Zusammenfassung 1. Mit einer empfindlichen Analysenmethode, die auf die Reaktion CO+HgO→CO2+Hg basiert und den CO-Gehalt auf Grund der Absorption des freigesetzten Hg bei 2537 Å ermittelt, wurden im Gasraum über wachsenden Kulturen von Saccharomyces cerevisiae, S. oviformis, Escherichia coli, Aerobacter aerogenes, Pseudomonas spec. und Lactobacillus brevis 0.4–2.6 ppm CO nachgewiesen. Bei Lactobacillus arabinosus, Bacillus cereus var. mycoides und Aspergillus niger war eine CO-Bildung nicht meßbar. 2. Bei S. cerevisiae war die CO-Bildung bei Konzentrationen von 10–50 g Glucose pro Liter Medium am größten. Außerdem wurde die CO-Bildung proportional zum anfänglichen Sauerstoffgehalt im Gasraum über den Kulturen gefördert. 3. Mit 14C-markierter Glucose wurde nachgewiesen, daß CO aus Glucose entsteht. 4. Die CO-Bildung der untersuchten Mikroorganismen ist so gering, daß sie keine Bedeutung für den Kreislauf dieses Spurengases in der Atmosphäre hat.
    Notes: Summary 1. Growing cultures of Saccharomyces cerevisiae, S. oviformis, Escherichia coli, Aerobacter aerogenes, Pseudomonas spec. and Lactobacillus brevis produce trace amounts of CO (0.4–2.6 ppm) that can be detected in the gas space above the cultures using a sensitive analytical method based on the reaction CO+HgO→CO2+Hg. The liberated Hg is quantitatively measured by atomic absorption at 2537 Å. No CO could be detected above cultures of Lactobacillus arabinosus, Bacillus cereus var. mycoides and Aspergillus niger. 2. The maximum CO production by Saccharomyces was obtained with concentrations of 10–50 g glucose per liter medium. The amount of CO formed increased with the oxygen concentration in the gas space above the cultures. 3. Using 14C-glucose it was shown that S. cerevisiae forms CO from glucose. 4. The formation of CO by the microorganisms investigated is very small. The ratio of CO/CO2 produced is much smaller than in environmental air. Therefore it can be concluded that the production of CO by these microorganisms has probably no significance for the atmospheric cycle of this trace gas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00446321
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  • 5
    Electronic Resource
    Electronic Resource
    Test Theory (1971)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Psychology 22 (1971), S. 193-224 
    Details
    ISSN: 0066-4308
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Psychology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.ps.22.020171.001205
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  • 6
    Electronic Resource
    Electronic Resource
    THE RECONSTRUCTION OF THE FATTY ACID OXIDIZING SYSTEM OF ANIMAL TISSUES (1953)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 75 (1953), S. 4111-4112 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja01112a536
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  • 7
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    Unknown
    A PARAMETERIZATION FOR INDIVIDUAL HUMAN GROWTH CURVES (1973)
    Baltimore : Periodicals Archive Online (PAO)
    Human Biology. 45:1 (1973:Feb.) 63 
    Details
    ISSN: 0018-7143
    Topics: Biology
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:5243-1973-045-01-000005
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  • 8
    Electronic Resource
    Electronic Resource
    Fluoreszenzmikroskopische Darstellung Aldehydfuchsin-positiver Substanzen mit Crotonaldehyd-Diaminobenzophenon (1970)
    Springer
    Histochemistry and cell biology 21 (1970), S. 181-188 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Description / Table of Contents: Zusammenfassung Es wird ein Verfahren zur elektiven Fluorochromierung Aldehydfuchsin-positiver Gewebsstrukturen beschrieben. Bei dem verwendeten Fluorochrom handelt es sich um eine Verbindung, die aus Crotonaldehyd und 4,4′-Diamino-benzophenon entsteht. Die nach dieser Methode gefärbten Schnitte können ohne Beeinträchtigung ihrer Fluoreszenz in Eukitt eingeschlossen und aufbewahrt werden. Das fluoreszenzoptische Verhalten der mit „Crotonaldehyd-Diaminobenzophenon“ fluorochromierten Strukturen wird mikrospektrofluorometrisch untersucht.
    Notes: Summary A staining procedure is described for the specific fluorochromation of tissue structures which are aldehyde fuchsin-positive. The fluorochrome is formed by a reaction of crotonaldehyde with 4,4′-diamino-benzophenone. The tissue sections stained by this technique can be mounted and preserved in Eukitt without alteration of their fluorescence. Structures fluorochromized with “crotonaldehydediaminobenzophenone” have been investigated by means of microspectrofluorometry.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00306185
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  • 9
    Electronic Resource
    Electronic Resource
    Zur Spaltbarkeit verschiedener Naphthol-Carbonsäureester durch Esterasen im Tanycytenependym des III. Ventrikels der Wistarratte (1970)
    Springer
    Histochemistry and cell biology 21 (1970), S. 353-365 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Description / Table of Contents: Zusammenfassung Im Tanycytenependym des III. Ventrikels kommen bei der Wistarratte unspezifische, E 600-empfindliche und gegenüber p-Chlormercuribenzoat resistente Esterasen vor. Um diese Enzyme histochemisch weiter zu charakterisieren, wurde ihre Fähigkeit geprüft, verschiedene Naphthol-Carbonsäureester bei Anwesenheit von Lösungsvermittlern zu spalten. Es zeigte sich hierbei ein unterschiedliches Verhalten der Esterasen in Ganglienzellen und Tanycyten. In letzteren weist von verschiedenen homologen Carbonsäureestern des α-Naphthols der Buttersäureester die höchste Spaltungsrate auf; Acetatester der Naphthol-AS-Reihe ergeben unterschiedliche, aber stets schwächere Reaktionen als α-Naphthylacetat. Wie in früheren Untersuchungen wurden Unterschiede im Verhalten der Esterasen-Aktivität in Perikaryen und Fortsätzen der Tanycyten beobachtet. — Auf Grund der Befunde wird die Möglichkeit einer Einschaltung der Tanycytenesterasen in die Erregungsübertragung diskutiert.
    Notes: Summary In the Wistar rat, the tanycytes of the IIIrd ventricle contain unspecific esterases which are E 600 sensitive and are not inhibited by p-chlormercuribenzoate. To further investigate the character of these enzymes, their ability to split various naphtholcarbonic acid esters in the presence of organic solvents was tested. It was hereby established that the esterases of the tanycytes behave differently to those of the diencephalic nerve cells. In the tanycytes among various homologous carbonic acid esters of α-naphthol applied, α-naphthyl butyrate shows the highest splitting ratio; with acetate esters of AS-naphtholes differing but always weaker reactions are obtained than with α-naphthyl-acetate. As in a former study, behavioral divergencies of esterase activity in the tanycyte perikaria and processes were observed. — On the basis of these findings the possibility is discussed that the esterases of the tanycytes might play a role in synaptic transmission.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00280904
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  • 10
    Electronic Resource
    Electronic Resource
    Histochemische Eigenschaften der unspezifischen Esterasen im Tanycytenependym des III. Ventrikels, im Subfornicalorgan und im Subcommissuralorgan der Wistarratte (1971)
    Springer
    Histochemistry and cell biology 28 (1971), S. 170-182 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Description / Table of Contents: Zusammenfassung An 40 männlichen Wistarratten wurden histochemisch differenzierbare Eigenschaften der unspezifischen Esterasen in den Tanycyten des III. Ventrikels, im Subfornicalorgan (SFO) und im Subcommissuralorgan (SCO) miteinander verglichen. Aus den Befunden geht hervor, daß die Esterasen des SFO in ihrem Verhalten denen der Tanycyten nahezu vollständig gleichen, während die Esterasen des SCO einen gänzlich anderen Typ verkörpern. Dieses Ergebnis könnte auf eine funktionelle Verwandtschaft von Tanycyten und Subfornicalorgan hinweisen.
    Notes: Summary In 40 male Wistar rats, a comparative study was made between the histochemically distinguishable properties of the unspecific esterases in the tanycytes of the third ventricle, in the subfornical organ (SFO) and in the subcommissural organ (SCO). The results show that the esterases of the SFO behave in an almost identical manner to those of the tanycytes, whereas the esterases of the SCO are of a completely different type. This finding could be an indication of a functional relationship between the tanycytes and the subfornical organ.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00279861
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