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  • 1970-1974  (15)
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Material
Years
Year
  • 1
    Electronic Resource
    Electronic Resource
    Simultaneous tumors in the respiratory system and urinary bladder of syrian golden hamsters (1974)
    Springer
    Journal of cancer research and clinical oncology 82 (1974), S. 153-158 
    Details
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die primär multiple Carcinogenese durch DBN wurde systematisch am Modell des Goldhamsters untersucht. Nach subcutaner wie auch nach intragastrischer Gabe fanden sich gleichzeitig Tumoren in Respirationssystem und in der Harnblase. Überlebenszeit, Tumorhäufigkeit und Latenzzeit waren abhängig von der Dosis. Papillome und Plattenepithelcarcinome zeigten sich in den Nasenhöhlen; papilläre Polypen wurden meist in Larynx, Trachea und Stammbrochien beobachtet, in den Lungen fanden sich gemischte und kombinierte Carcinome. Die Harnblase zeigte Übergangsepithelpapillome und -Carcinome.
    Notes: Summary The hamster was used as a model for systematic studies in primary multiple carcinogenesis induced by DBN. After subcutaneous and intragastric treatment, neoplasms were simultaneously found in the respiratory system and in the urinary bladder. A dose dependent effect was seen for survival, tumor incidence and latency. Papillomas and epidermoid carcinomas were found in the nasal cavities; papillary polyps were mainly found in the larynx, trachea and stem bronchi whereas mixed and combined carcinomas were observed in the lungs. The urinary bladder showed transitional cell papillomas and carcinomas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00284500
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  • 2
    Electronic Resource
    Electronic Resource
    The influence of hibernation upon the carcinogenic effect of N-diethylnitrosamine in European hamsters (1973)
    Springer
    Journal of cancer research and clinical oncology 80 (1973), S. 285-288 
    Details
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 120 wild eingefangenen europäischen Feldhamstern (Cricetus cricetus L.) wurde das Carcinogen N-diäthylnitrosamin subcutan verabreicht. 60 Tiere wurden unter Bedingungen des Winterschlafs, die anderen 60 Tiere unter standardisierten Laborbedingungen gehalten. In beiden Gruppen fanden sich Tumoren, vorwiegend im Respirationstrakt. Bei den winterschlafenden Tieren lagen die durchschnittlichen Überlebenszeiten höher und bei insgesamt geringeren Ausbeuten entstanden die Tumoren später.
    Notes: Summary N-diethylnitrosamine (DEN) was given subcutaneously to 120 captured European hamsters (Cricetus cricetus L.). Half of the animals were kept under conditions conducive to hibernation and half under standard laboratory conditions. Neoplasms of the respiratory system were found in both groups. In comparison to nonhibernating animals, the average survival rates for the hibernating animals was increased and the latter developed tumours later and in a lower frequency.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00284362
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  • 3
    Electronic Resource
    Electronic Resource
    Melanoma in the North of Thailand in the last ten years (1973)
    Springer
    Journal of cancer research and clinical oncology 80 (1973), S. 31-35 
    Details
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Gewebsproben der Melanomfälle der letzten 10 Jahre aus dem Pathologischen Institut der Universität Chiang Mai, Nord-Thailand, wurden nachuntersucht und soweit erhältlich, die Angaben der Krankengeschichten bei der Auswertung berücksichtigt. Unterschiede hinsichtlich der Lokalisation sowie der Häufigkeit der Melanome in bezug zum Alter und Geschlecht wurden beschrieben. Über 50% der Geschwülste zeigten sich im Bereich der unteren Extremitäten; Männer erkrankten häufiger als Frauen.
    Notes: Summary The cases of melanoma diagnosed at the Chiang Mai University Medical School in the last ten years were histologically re-examined and the case histories, when avalaible, were evaluated. The different anatomical locations of melanoma related to age and sex of the patients were analysed. More than 50% of the melanomas were found on the lower extremities. The frequency of the tumours was higher in males than in females.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00285312
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  • 4
    Electronic Resource
    Electronic Resource
    The carcinogenic effect of dibutylnitrosamine in Syrian and Chinese hamsters (1970)
    Springer
    Journal of cancer research and clinical oncology 74 (1970), S. 112-113 
    Details
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Orally and subcutaneously administered dibutylnitrosamine caused tracheal papillomata, lung tumors, some papillomata of the forestomach and the urinary bladder in Syrian hamsters, while Chinese hamsters showed numerous papillomata of the forestomach and slight changes of the bladder epithelium.
    Notes: Zusammenfassung 13–30 Wochen nach oraler bzw. subcutaner Verabreichung von Dibutylnitrosamin entstanden bei syrischen Hamstern Trachealpapillome, Lungentumoren und einige Papillome des Vormagens und der Harnblase, während sich bei chinesischen Hamstern außer vergleichbaren Blasenepithelveränderungen in einem hohen Prozentsatz Vormagenpapillome entwickelten.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00524687
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  • 5
    Electronic Resource
    Electronic Resource
    Untersuchungen zur Stimulation der Lungentumorrate durch Diäthylnitrosamin bei O-20-Mäusen (1971)
    Springer
    Journal of cancer research and clinical oncology 75 (1971), S. 240-242 
    Details
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 100 weibliche und männliche O-20-Mäuse erhielten ein-bzw. zweimal wöchentlich 50 mg/kg KG Diäthylnitrosamin subcutan über 4 Wochen. Neben den bekannten Leberveränderungen zeigte sich die Zunahme der Lungenadenomrate bei erheblich verkürzter Latenzzeit.
    Notes: Summary 50 mg/kg body weight of di-ethyl-nitrosamine was administered subcutaneously to 100 female and male O-20-mice once or twice weekly over a period of 4 weeks. Beside the well-known changes of the liver an increase of the rate of lung adenomas at significantly shortened latency period could be observed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00524521
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  • 6
    Electronic Resource
    Electronic Resource
    Comparative studies of neoplastic response to a single dose of nitroso compounds (1972)
    Springer
    Journal of cancer research and clinical oncology 78 (1972), S. 78-81 
    Details
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Nach subcutaner Verabreichung von N-nitrosohexamethylenimin fanden sich bei syrischen Goldhamstern Tumoren vorwiegend der Trachea (Papillome). Bei Swiss-Mäusen wurde — im Vergleich zu Kontrollen — eine geringe Zunahme der Lungentumorrate (Adenome) beobachtet. Es konnte gezeigt werden, daß insbesondere bei syrischen Goldhamstern die Verabreichung einer Einzeldosis von 4 mg/kg Körpergewicht N-Nitrosohexamethylenimin zur Induktion von Tumoren im Respirationstrakt ausreicht.
    Notes: Summary After subcutaneous treatment with N-nitrosohexamethyleneimine, Syrian golden hamsters showed mainly papillary tumors of the trachea. In Swiss mice, the development of lung adenomas was slightly stimulated compared with controls. These experiments have shown that a single dose of 4 mg/kg b.w. of N-nitrosohexamethyleneimine is sufficient to induce tumors in the respiratory system of Syrian golden hamsters.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00284315
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  • 7
    Electronic Resource
    Electronic Resource
    The carcinogenic effect of 2-oxo-propyl-propylnitrosamine in Sprague-Dawley rats (1974)
    Springer
    Journal of cancer research and clinical oncology 81 (1974), S. 23-28 
    Details
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die chronische Wirkung von 2-Oxo-propyl-propylnitrosamin (2-OPPN) wurde an Sprague-Dawley Ratten untersucht. Die Tiere zeigten vorwiegend hepatocelluläre Carcinome, die Wirkung dieses Carcinogens war dosisabhängig. Die Ergebnisse wurden unter der Annahme diskutiert, daß 2-OPPN möglicherweise ein Metabolit des Di-n-propylnitrosamins ist.
    Notes: Summary The chronic effect of 2-oxo-propyl-propylnitrosamine (2-OPPN) was examined in Sprague-Dawley rats. The animals showed mainly hepatocellular carcinomata; the effect of the carcinogen was dose dependent. The findings are discussed under the assumption that 2-OPPN might be a metabolite of di-n-propylnitrosamine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00303597
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  • 8
    Electronic Resource
    Electronic Resource
    Carcinogenicity ofβ-hydroxylated dipropylnitrosamine (1973)
    Springer
    Naturwissenschaften 60 (1973), S. 55-55 
    Details
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00591776
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  • 9
    Electronic Resource
    Electronic Resource
    Induction of pancreas tumours by di-isopropanolnitrosamine (1974)
    Springer
    Naturwissenschaften 61 (1974), S. 328-328 
    Details
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00599567
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  • 10
    Electronic Resource
    Electronic Resource
    Effects of intraperitoneal injections of dimethyl- and diethylnitrosamine, alone or simultaneously on Swiss mice (1974)
    Springer
    Journal of cancer research and clinical oncology 82 (1974), S. 233-238 
    Details
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Swiss-Mäuse erhielten intraperitoneal entweder DMN oder DEN oder beide Substanzen simultan, wodurch sich vergleichsweise zu den Kontrollen eine höhere Lungentumorrate ergab: Während DMN behandelte Tiere gehäuft Carcinome zeigten, wurden nach simultaner DMN + DEN-Behandlung vorwiegend atypische Adenome bzw. nach DEN-Gaben Adenome beobachtet. Die Behandlung nur mit DMN führte bei den Swiss-Mäusen noch zu retroperitonealen vasculären Neoplasmen und zu einigen Nierenadenomen. Papillome des Vormagens fanden sich bei Tieren der DEN bzw. DMN + DEN-Versuchsgruppen. Die Anzahl der nachgewiesenen Lymphome in allen carcinogen-behandelten Tieren bewegt sich im Bereich der Spontantumorrate
    Notes: Summary Swiss mice were treated i.p. with DMN and DEN either alone or simultaneously. In comparison to controls, the lung tumour incidence was increased in the carcinogen treated groups. Whereas DMN frequently caused lung carcinomata, DEN treated mice showed mainly lung adenomata; atypical adenomata were mostly found after simultaneous applications of DMN and DEN. Retroperitoneal vascular tumours and kidney adenomata were observed only after DMN treatment. Forestomach papillomata were seen in the groups receiving DEN and DMN + DEN. The rate of malignant lymphomata for all carcinogen treated mice fluctuated within the realm of a spontaneous tumour rate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00304061
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