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  • 1
    Electronic Resource
    Electronic Resource
    Chronic anorexic and behavioural effects of the fenfluramine derivative SE 780 in rats (1974)
    Springer
    Psychopharmacology 35 (1974), S. 13-17 
    Details
    ISSN: 1432-2072
    Keywords: Anorexia ; Time Sampling ; Fenfluramine ; SE 780
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The behavioural and anorexic effects of the fenfluramine derivative “SE 780” in rats were studied after chronic administration over 35 days. Behavioural effects of the compound were assessed by “time sampling” behavioural categorisation, on days 1, 14 and 28 of administration. An initial sedative effect observed after acute administration was absent on days 14 and 28 of observation, when the drug had no behavioural effects at all. The anorexic properties of the drug were investigated in two ways. Firstly, by measuring daily body weights; and secondly by measuring intake of food over a 2 h period on observation days. The drug appeared to be a highly potent anorexiant in that tolerance to its effects built up very slowly. It is suggested that SE 780 may be an anorexic agent which is superior to Fenfluramine in two ways; firstly, it lacks stimulant properties after chronic administration, and secondly it is active over longer periods of time; as such it merits further study in humans.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00421561
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  • 2
    Electronic Resource
    Electronic Resource
    Chronic anorexic and behavioural effects of the fenfluramine metabolite, norfenfluramine: An evaluation of its role in the actions of fenfluramine (1974)
    Springer
    Psychopharmacology 38 (1974), S. 67-74 
    Details
    ISSN: 1432-2072
    Keywords: Fenfluramine ; Norfenfluramine ; Anorexia ; Activity Analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The anorexic and behavioural effects of Norfenfluramine were studied in rats. Two separate experiments were conducted involving administration by intra-peritoneal and sub-cutaneous routes respectively. Behavioural effects were assessed by time sampling categorisation on Days 1 and 14 of a 20 day chronic study and anorexic effects by daily weighing. Norfenfluramine was found to be a potent anorexiant, to which tolerance is established fairly quickly. It was also found to possess sedative properties after acute administration, but marked stimulant properties after 14 days chronic administration. These results are similar to those previously reported in a study of Fenfluramine, although the behavioural effects of Norfenfluramine are more marked. The results implicate Norfenfluramine in the anorexic and behavioural effects of Fenfluramine, and provide indirect confirmation of the suggestion made in an earlier paper that Fenfluramine may have chronic stimulant properties.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00421288
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    The effects of chronic fenfluramine administration on behaviour and body weight (1973)
    Springer
    Psychopharmacology 31 (1973), S. 63-76 
    Details
    ISSN: 1432-2072
    Keywords: Fenfluramine ; Anorexia ; Activity Analysis ; C.N.S. Stimulation ; Stereotyped Behaviour
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Two experiments were conducted on the effects of chronic administration of fenfluramine on behaviour and body weight in rats. In Experiment One the effects of 28 day chronic administration were studied. A dose related rapid weight loss was observed in treated subjects, with development of tolerance to the effects of the drug on body weight after 14 days administration. Observations of behaviour were made on days 1, 14 and 28 of chronic administration according to a “time sampling” procedure of behavioural categorisation. The incidence of some behavioural patterns varied significantly between observation days, although observations of control subjects were never significantly different. By the 28th day of administration tolerance to the behavioural effects of the drug had developed, no dose/response eifects being noted in contrast to the results for prior observation days. In Experiment Two confirmation of the development of behavioural tolerance was obtained. Abnormal, “stereotyped” behaviour induced by a very high dose of fenfluramine showed a much lower incidence in subjects that hadr eceived fenfluramine for 30 days than in saline controls. Attention is drawn to the difficulties inherent in describing psychotropic agents as either sedatives or stimulants. It is suggested that although fenfluramine is generally considered to be a sedative, stimulant effects may be observed after chronic administration of anorexic doses. Similarities between the effects of high doses of fenfluramine and amphetamine are described.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00429299
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  • 4
    Electronic Resource
    Electronic Resource
    Time sampling of rat exploratory behaviour: A reliable screening test for the C.N.S. effects of anorexic agents (1974)
    Springer
    Psychopharmacology 35 (1974), S. 1-12 
    Details
    ISSN: 1432-2072
    Keywords: Anorexiants ; Activity Analysis ; Time Sampling ; Screening Tests ; Phenylethylamines ; Serotonin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A series of eight experiments were conducted on the acute effects of a number of anorexic agents on rat exploratory behaviour, as assessed by a “time sampling” procedure of behavioural categorisation. Compounds studied were of three types. Firstly, some well known anorexiants (Amphetamine, Diethylpropion, Fenfluramine); secondly, a series of fenfluramine derivatives (Norfenfluramine, SE 780, SE 1513 and SKF 1-39728); and thirdly, an indole derivative (U 22-394A). All the compounds except the latter are based upon a phenylethylamine configuration. The results indicate that amphetamine and diethylpropion are stimulants whilst fenfluramine is a sedative, in accord with the clinical reports of the effects of acute administration of these compounds. All the other phenylethylamines and U 22-394A were found to be sedatives. The technique of activity analysis described here is a useful screening test for psychotropic agents which affect C.N.S. excitability in humans, which is probably superior to other measures of activity in its predictive value. However, it is noted that the effects of acute administration do not always provide a reliable index of chronic effects. The compounds SE 780 and SKF 1-39728 would seem to merit further study. It is suggested that all the fenfluramine derivatives, except SKF 1-39728, have a similar mode of anorexic action to U 22-394A.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00421560
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  • 5
    Electronic Resource
    Electronic Resource
    Comparison between behaviours elicited by high doses of amphetamine and fenfluramine: Implications for the concept of stereotypy (1974)
    Springer
    Psychopharmacology 40 (1974), S. 249-258 
    Details
    ISSN: 1432-2072
    Keywords: Amphetamine ; Fenfluramine ; Stereotypy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The behavioural effects of a range of high doses of D-amphetamine and DL-fenfluramine were investigated in rats. Subjects were observed individually for 1 min in every 5 for a period of an hour. During each observation period the presence of any of 6 behavioural patterns was recorded in an “all or none”; fashion Behaviour patterns recorded included: Rearing, Forward Locomotion, Immobility, Backward Locomotion, Circling and Head Swaying. The last 3 behaviours are considered “Abnormal”; in that they were never observed in saline treated controls. The results indicate that, at the doses used in this study, both compounds induce abnormal behaviours, the latency of onset of which is directly proportional to dose. For both compounds an inverse correlation was found between normal and abnormal behaviours. However, the type of abnormal behaviour observed differed considerably between drugs in that fenfluramine elicited Backward Walking and Circling with no Head Swaying, over the dose range 10–30 mg per kg; whilst the predominant abnormal behaviour elicited by D-amphetamine, over the range 5–20 mg per kg, was Head Swaying. At the highest doses of amphetamine used some Backward Walking was elicited, behaviour which was totally absent at the lower doses. The implications of these results for the concept of “stereotypy”; are discussed, and attention is drawn to an important distinction between abnormal and stereotyped behaviour.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00429419
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    Paper (German National Licenses)
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